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Mapping the KRAS proteoform landscape in colorectal cancer identifies truncated KRAS4B that decreases MAPK signaling.

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Title: Mapping the KRAS proteoform landscape in colorectal cancer identifies truncated KRAS4B that decreases MAPK signaling.
Authors: Adams LM; Department of Molecular Biosciences, Northwestern University, Evanston, Illinois, USA., DeHart CJ; NCI RAS Initiative, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA., Drown BS; Department of Chemistry, Northwestern University, Evanston, Illinois, USA., Anderson LC; Ion Cyclotron Resonance Program, National High Magnetic Field Laboratory, Tallahassee, Florida, USA., Bocik W; Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA., Boja ES; Office of Cancer Clinical Proteomics Research, National Cancer Institute, Bethesda, Maryland, USA., Hiltke TM; Office of Cancer Clinical Proteomics Research, National Cancer Institute, Bethesda, Maryland, USA., Hendrickson CL; Ion Cyclotron Resonance Program, National High Magnetic Field Laboratory, Tallahassee, Florida, USA., Rodriguez H; Office of Cancer Clinical Proteomics Research, National Cancer Institute, Bethesda, Maryland, USA., Caldwell M; Division of Hematology and Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA; Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois, USA; Proteomics Center of Excellence, Northwestern University, Evanston, Illinois, USA., Vafabakhsh R; Department of Molecular Biosciences, Northwestern University, Evanston, Illinois, USA., Kelleher NL; Department of Molecular Biosciences, Northwestern University, Evanston, Illinois, USA; Department of Chemistry, Northwestern University, Evanston, Illinois, USA; Division of Hematology and Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA; Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois, USA; Proteomics Center of Excellence, Northwestern University, Evanston, Illinois, USA. Electronic address: n-kelleher@northwestern.edu.
Source: The Journal of biological chemistry [J Biol Chem] 2023 Jan; Vol. 299 (1), pp. 102768. Date of Electronic Publication: 2022 Dec 05.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Mapping the KRAS proteoform landscape in colorectal cancer identifies truncated KRAS4B that decreases MAPK signaling.
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  Data: <searchLink fieldCode="AU" term="%22Adams+LM%22">Adams LM</searchLink>; Department of Molecular Biosciences, Northwestern University, Evanston, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22DeHart+CJ%22">DeHart CJ</searchLink>; NCI RAS Initiative, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Drown+BS%22">Drown BS</searchLink>; Department of Chemistry, Northwestern University, Evanston, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Anderson+LC%22">Anderson LC</searchLink>; Ion Cyclotron Resonance Program, National High Magnetic Field Laboratory, Tallahassee, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Bocik+W%22">Bocik W</searchLink>; Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Boja+ES%22">Boja ES</searchLink>; Office of Cancer Clinical Proteomics Research, National Cancer Institute, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Hiltke+TM%22">Hiltke TM</searchLink>; Office of Cancer Clinical Proteomics Research, National Cancer Institute, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Hendrickson+CL%22">Hendrickson CL</searchLink>; Ion Cyclotron Resonance Program, National High Magnetic Field Laboratory, Tallahassee, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Rodriguez+H%22">Rodriguez H</searchLink>; Office of Cancer Clinical Proteomics Research, National Cancer Institute, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Caldwell+M%22">Caldwell M</searchLink>; Division of Hematology and Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA; Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois, USA; Proteomics Center of Excellence, Northwestern University, Evanston, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Vafabakhsh+R%22">Vafabakhsh R</searchLink>; Department of Molecular Biosciences, Northwestern University, Evanston, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Kelleher+NL%22">Kelleher NL</searchLink>; Department of Molecular Biosciences, Northwestern University, Evanston, Illinois, USA; Department of Chemistry, Northwestern University, Evanston, Illinois, USA; Division of Hematology and Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA; Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois, USA; Proteomics Center of Excellence, Northwestern University, Evanston, Illinois, USA. Electronic address: n-kelleher@northwestern.edu.
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  Data: <searchLink fieldCode="JN" term="%222985121R%22">The Journal of biological chemistry</searchLink> [J Biol Chem] 2023 Jan; Vol. 299 (1), pp. 102768. <i>Date of Electronic Publication: </i>2022 Dec 05.
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