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Alzheimer's disease-associated R47H TREM2 increases, but wild-type TREM2 decreases, microglial phagocytosis of synaptosomes and neuronal loss.

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Title: Alzheimer's disease-associated R47H TREM2 increases, but wild-type TREM2 decreases, microglial phagocytosis of synaptosomes and neuronal loss.
Authors: Popescu AS; Department of Biochemistry, University of Cambridge, Cambridge, UK., Butler CA; Department of Biochemistry, University of Cambridge, Cambridge, UK.; Neuroscience, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Allendorf DH; Department of Biochemistry, University of Cambridge, Cambridge, UK., Piers TM; Department of Neuroinflammation, UCL Queen Square Institute of Neurology, London, UK., Mallach A; Department of Neuroinflammation, UCL Queen Square Institute of Neurology, London, UK., Roewe J; Neuroscience Discovery, AbbVie Deutschland GmbH & Co. KG, Ludwigshafen, Germany., Reinhardt P; Neuroscience Discovery, AbbVie Deutschland GmbH & Co. KG, Ludwigshafen, Germany., Cinti A; Cell Biology, Axxam SpA, Milan, Italy., Redaelli L; Cell Biology, Axxam SpA, Milan, Italy., Boudesco C; Rare and Neuro Diseases, Sanofi R&D, Chilly-Mazarin, France., Pradier L; Rare and Neuro Diseases, Sanofi R&D, Chilly-Mazarin, France., Pocock JM; Department of Neuroinflammation, UCL Queen Square Institute of Neurology, London, UK., Thornton P; Neuroscience, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Brown GC; Department of Biochemistry, University of Cambridge, Cambridge, UK.
Source: Glia [Glia] 2023 Apr; Vol. 71 (4), pp. 974-990. Date of Electronic Publication: 2022 Dec 08.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8806785 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-1136 (Electronic) Linking ISSN: 08941491 NLM ISO Abbreviation: Glia Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Alzheimer's disease-associated R47H TREM2 increases, but wild-type TREM2 decreases, microglial phagocytosis of synaptosomes and neuronal loss.
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  Data: <searchLink fieldCode="AU" term="%22Popescu+AS%22">Popescu AS</searchLink>; Department of Biochemistry, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Butler+CA%22">Butler CA</searchLink>; Department of Biochemistry, University of Cambridge, Cambridge, UK.; Neuroscience, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Allendorf+DH%22">Allendorf DH</searchLink>; Department of Biochemistry, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Piers+TM%22">Piers TM</searchLink>; Department of Neuroinflammation, UCL Queen Square Institute of Neurology, London, UK.<br /><searchLink fieldCode="AU" term="%22Mallach+A%22">Mallach A</searchLink>; Department of Neuroinflammation, UCL Queen Square Institute of Neurology, London, UK.<br /><searchLink fieldCode="AU" term="%22Roewe+J%22">Roewe J</searchLink>; Neuroscience Discovery, AbbVie Deutschland GmbH & Co. KG, Ludwigshafen, Germany.<br /><searchLink fieldCode="AU" term="%22Reinhardt+P%22">Reinhardt P</searchLink>; Neuroscience Discovery, AbbVie Deutschland GmbH & Co. KG, Ludwigshafen, Germany.<br /><searchLink fieldCode="AU" term="%22Cinti+A%22">Cinti A</searchLink>; Cell Biology, Axxam SpA, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Redaelli+L%22">Redaelli L</searchLink>; Cell Biology, Axxam SpA, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Boudesco+C%22">Boudesco C</searchLink>; Rare and Neuro Diseases, Sanofi R&D, Chilly-Mazarin, France.<br /><searchLink fieldCode="AU" term="%22Pradier+L%22">Pradier L</searchLink>; Rare and Neuro Diseases, Sanofi R&D, Chilly-Mazarin, France.<br /><searchLink fieldCode="AU" term="%22Pocock+JM%22">Pocock JM</searchLink>; Department of Neuroinflammation, UCL Queen Square Institute of Neurology, London, UK.<br /><searchLink fieldCode="AU" term="%22Thornton+P%22">Thornton P</searchLink>; Neuroscience, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Brown+GC%22">Brown GC</searchLink>; Department of Biochemistry, University of Cambridge, Cambridge, UK.
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  Data: <searchLink fieldCode="JN" term="%228806785%22">Glia</searchLink> [Glia] 2023 Apr; Vol. 71 (4), pp. 974-990. <i>Date of Electronic Publication: </i>2022 Dec 08.
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