Neutralising antibody potency against SARS-CoV-2 wild-type and omicron BA.1 and BA.4/5 variants in patients with inflammatory bowel disease treated with infliximab and vedolizumab after three doses of COVID-19 vaccine (CLARITY IBD): an analysis of a prospective multicentre cohort study.

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Title: Neutralising antibody potency against SARS-CoV-2 wild-type and omicron BA.1 and BA.4/5 variants in patients with inflammatory bowel disease treated with infliximab and vedolizumab after three doses of COVID-19 vaccine (CLARITY IBD): an analysis of a prospective multicentre cohort study.
Authors: Liu Z; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK., Le K; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK., Zhou X; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK., Alexander JL; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK; Department of Gastroenterology, Imperial College Healthcare NHS Trust, London, UK., Lin S; Department of Gastroenterology, Royal Devon University Healthcare NHS Foundation Trust, Exeter, UK; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, UK., Bewshea C; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, UK., Chanchlani N; Department of Gastroenterology, Royal Devon University Healthcare NHS Foundation Trust, Exeter, UK; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, UK., Nice R; Department of Biochemistry, Exeter Clinical Laboratory International, Royal Devon University Healthcare NHS Foundation Trust, Exeter, UK; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, UK., McDonald TJ; Department of Biochemistry, Exeter Clinical Laboratory International, Royal Devon University Healthcare NHS Foundation Trust, Exeter, UK., Lamb CA; Department of Gastroenterology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Sebastian S; Hull York Medical School, University of Hull, Hull, UK; Department of Gastroenterology, Hull University Teaching Hospitals NHS Trust, Hull, UK., Kok K; Department of Gastroenterology, Bart's Health NHS Trust, London, UK., Lees CW; Department of Gastroenterology, Western General Hospital, NHS Lothian, Edinburgh, UK; Centre for Inflammation Research, The Queen's Medical Research Institute, The University of Edinburgh, Edinburgh, UK., Hart AL; Department of Gastroenterology, St Marks Hospital and Academic Institute, London, UK., Pollok RC; Department of Gastroenterology, St George's University Hospitals NHS Foundation Trust, London, UK; Institute for Infection and Immunity, St George's University of London, London, UK., Boyton RJ; Department of Infectious Disease, Imperial College London, London, UK; Lung Division, Royal Brompton and Harefield Hospitals, Guy's and St Thomas' NHS Foundation Trust, London, UK., Altmann DM; Department of Immunology and Inflammation, Imperial College London, London, UK., Pollock KM; Department of Infectious Disease, Imperial College London, London, UK; NIHR Imperial Clinical Research Facility and NIHR Imperial Biomedical Research Centre, London, UK., Goodhand JR; Department of Gastroenterology, Royal Devon University Healthcare NHS Foundation Trust, Exeter, UK; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, UK., Kennedy NA; Department of Gastroenterology, Royal Devon University Healthcare NHS Foundation Trust, Exeter, UK; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, UK., Ahmad T; Department of Gastroenterology, Royal Devon University Healthcare NHS Foundation Trust, Exeter, UK; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, UK., Powell N; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK; Department of Gastroenterology, Imperial College Healthcare NHS Trust, London, UK. Electronic address: npowell@imperial.ac.uk.
Corporate Authors: CLARITY study investigators
Source: The lancet. Gastroenterology & hepatology [Lancet Gastroenterol Hepatol] 2023 Feb; Vol. 8 (2), pp. 145-156. Date of Electronic Publication: 2022 Dec 05.
Publication Type: Observational Study; Multicenter Study; Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101690683 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2468-1253 (Electronic) NLM ISO Abbreviation: Lancet Gastroenterol Hepatol Subsets: MEDLINE
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  Data: Neutralising antibody potency against SARS-CoV-2 wild-type and omicron BA.1 and BA.4/5 variants in patients with inflammatory bowel disease treated with infliximab and vedolizumab after three doses of COVID-19 vaccine (CLARITY IBD): an analysis of a prospective multicentre cohort study.
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  Data: <searchLink fieldCode="AU" term="%22Liu+Z%22">Liu Z</searchLink>; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Le+K%22">Le K</searchLink>; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Zhou+X%22">Zhou X</searchLink>; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Alexander+JL%22">Alexander JL</searchLink>; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK; Department of Gastroenterology, Imperial College Healthcare NHS Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Lin+S%22">Lin S</searchLink>; Department of Gastroenterology, Royal Devon University Healthcare NHS Foundation Trust, Exeter, UK; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, UK.<br /><searchLink fieldCode="AU" term="%22Bewshea+C%22">Bewshea C</searchLink>; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, UK.<br /><searchLink fieldCode="AU" term="%22Chanchlani+N%22">Chanchlani N</searchLink>; Department of Gastroenterology, Royal Devon University Healthcare NHS Foundation Trust, Exeter, UK; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, UK.<br /><searchLink fieldCode="AU" term="%22Nice+R%22">Nice R</searchLink>; Department of Biochemistry, Exeter Clinical Laboratory International, Royal Devon University Healthcare NHS Foundation Trust, Exeter, UK; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, UK.<br /><searchLink fieldCode="AU" term="%22McDonald+TJ%22">McDonald TJ</searchLink>; Department of Biochemistry, Exeter Clinical Laboratory International, Royal Devon University Healthcare NHS Foundation Trust, Exeter, UK.<br /><searchLink fieldCode="AU" term="%22Lamb+CA%22">Lamb CA</searchLink>; Department of Gastroenterology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Sebastian+S%22">Sebastian S</searchLink>; Hull York Medical School, University of Hull, Hull, UK; Department of Gastroenterology, Hull University Teaching Hospitals NHS Trust, Hull, UK.<br /><searchLink fieldCode="AU" term="%22Kok+K%22">Kok K</searchLink>; Department of Gastroenterology, Bart's Health NHS Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Lees+CW%22">Lees CW</searchLink>; Department of Gastroenterology, Western General Hospital, NHS Lothian, Edinburgh, UK; Centre for Inflammation Research, The Queen's Medical Research Institute, The University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Hart+AL%22">Hart AL</searchLink>; Department of Gastroenterology, St Marks Hospital and Academic Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Pollok+RC%22">Pollok RC</searchLink>; Department of Gastroenterology, St George's University Hospitals NHS Foundation Trust, London, UK; Institute for Infection and Immunity, St George's University of London, London, UK.<br /><searchLink fieldCode="AU" term="%22Boyton+RJ%22">Boyton RJ</searchLink>; Department of Infectious Disease, Imperial College London, London, UK; Lung Division, Royal Brompton and Harefield Hospitals, Guy's and St Thomas' NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Altmann+DM%22">Altmann DM</searchLink>; Department of Immunology and Inflammation, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Pollock+KM%22">Pollock KM</searchLink>; Department of Infectious Disease, Imperial College London, London, UK; NIHR Imperial Clinical Research Facility and NIHR Imperial Biomedical Research Centre, London, UK.<br /><searchLink fieldCode="AU" term="%22Goodhand+JR%22">Goodhand JR</searchLink>; Department of Gastroenterology, Royal Devon University Healthcare NHS Foundation Trust, Exeter, UK; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, UK.<br /><searchLink fieldCode="AU" term="%22Kennedy+NA%22">Kennedy NA</searchLink>; Department of Gastroenterology, Royal Devon University Healthcare NHS Foundation Trust, Exeter, UK; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, UK.<br /><searchLink fieldCode="AU" term="%22Ahmad+T%22">Ahmad T</searchLink>; Department of Gastroenterology, Royal Devon University Healthcare NHS Foundation Trust, Exeter, UK; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, UK.<br /><searchLink fieldCode="AU" term="%22Powell+N%22">Powell N</searchLink>; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK; Department of Gastroenterology, Imperial College Healthcare NHS Trust, London, UK. Electronic address: npowell@imperial.ac.uk.
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