Ovarian cancer mutational processes drive site-specific immune evasion.
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| Title: | Ovarian cancer mutational processes drive site-specific immune evasion. |
|---|---|
| Authors: | Vázquez-García I; Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Uhlitz F; Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Ceglia N; Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Lim JLP; Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Wu M; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Mohibullah N; Integrated Genomics Operation, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Niyazov J; Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Ruiz AEB; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Boehm KM; Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Bojilova V; Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Fong CJ; Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Funnell T; Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Grewal D; Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Havasov E; Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Leung S; Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Pasha A; Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Patel DM; Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Pourmaleki M; Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Rusk N; Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Shi H; Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Vanguri R; Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Williams MJ; Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Zhang AW; Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Broach V; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Chi DS; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Da Cruz Paula A; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Gardner GJ; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Kim SH; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Lennon M; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Long Roche K; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Sonoda Y; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Zivanovic O; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Kundra R; Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Viale A; Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Derakhshan FN; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Geneslaw L; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Issa Bhaloo S; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Maroldi A; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Nunez R; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Pareja F; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Stylianou A; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Vahdatinia M; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Bykov Y; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Grisham RN; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Weill Cornell Medical Center, New York, NY, USA., Liu YL; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Weill Cornell Medical Center, New York, NY, USA., Lakhman Y; Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Nikolovski I; Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Kelly D; Department of Information Systems, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Gao J; Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Schietinger A; Weill Cornell Medical Center, New York, NY, USA.; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Hollmann TJ; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Bristol Myers Squibb, Princeton, NJ, USA., Bakhoum SF; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Soslow RA; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Ellenson LH; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Abu-Rustum NR; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Weill Cornell Medical Center, New York, NY, USA., Aghajanian C; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Friedman CF; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Weill Cornell Medical Center, New York, NY, USA., McPherson A; Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Weigelt B; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Zamarin D; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. zamarind@mskcc.org.; Weill Cornell Medical Center, New York, NY, USA. zamarind@mskcc.org., Shah SP; Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA. shahs3@mskcc.org. |
| Source: | Nature [Nature] 2022 Dec; Vol. 612 (7941), pp. 778-786. Date of Electronic Publication: 2022 Dec 14. |
| Publication Type: | Journal Article; Research Support, U.S. Gov't, P.H.S.; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 36517593 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Ovarian cancer mutational processes drive site-specific immune evasion. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Vázquez-García+I%22">Vázquez-García I</searchLink>; Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Uhlitz+F%22">Uhlitz F</searchLink>; Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Ceglia+N%22">Ceglia N</searchLink>; Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Lim+JLP%22">Lim JLP</searchLink>; Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Wu+M%22">Wu M</searchLink>; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Mohibullah+N%22">Mohibullah N</searchLink>; Integrated Genomics Operation, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Niyazov+J%22">Niyazov J</searchLink>; Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Ruiz+AEB%22">Ruiz AEB</searchLink>; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Boehm+KM%22">Boehm KM</searchLink>; Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Bojilova+V%22">Bojilova V</searchLink>; Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Fong+CJ%22">Fong CJ</searchLink>; Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Funnell+T%22">Funnell T</searchLink>; Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Grewal+D%22">Grewal D</searchLink>; Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Havasov+E%22">Havasov E</searchLink>; Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Leung+S%22">Leung S</searchLink>; Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Pasha+A%22">Pasha A</searchLink>; Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Patel+DM%22">Patel DM</searchLink>; Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Pourmaleki+M%22">Pourmaleki M</searchLink>; Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Rusk+N%22">Rusk N</searchLink>; Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Shi+H%22">Shi H</searchLink>; Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Vanguri+R%22">Vanguri R</searchLink>; Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Williams+MJ%22">Williams MJ</searchLink>; Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+AW%22">Zhang AW</searchLink>; Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Broach+V%22">Broach V</searchLink>; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Chi+DS%22">Chi DS</searchLink>; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Da+Cruz+Paula+A%22">Da Cruz Paula A</searchLink>; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Gardner+GJ%22">Gardner GJ</searchLink>; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Kim+SH%22">Kim SH</searchLink>; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Lennon+M%22">Lennon M</searchLink>; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Long+Roche+K%22">Long Roche K</searchLink>; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Sonoda+Y%22">Sonoda Y</searchLink>; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Zivanovic+O%22">Zivanovic O</searchLink>; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Kundra+R%22">Kundra R</searchLink>; Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Viale+A%22">Viale A</searchLink>; Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Derakhshan+FN%22">Derakhshan FN</searchLink>; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Geneslaw+L%22">Geneslaw L</searchLink>; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Issa+Bhaloo+S%22">Issa Bhaloo S</searchLink>; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Maroldi+A%22">Maroldi A</searchLink>; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Nunez+R%22">Nunez R</searchLink>; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Pareja+F%22">Pareja F</searchLink>; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Stylianou+A%22">Stylianou A</searchLink>; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Vahdatinia+M%22">Vahdatinia M</searchLink>; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Bykov+Y%22">Bykov Y</searchLink>; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Grisham+RN%22">Grisham RN</searchLink>; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Weill Cornell Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Liu+YL%22">Liu YL</searchLink>; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Weill Cornell Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Lakhman+Y%22">Lakhman Y</searchLink>; Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Nikolovski+I%22">Nikolovski I</searchLink>; Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Kelly+D%22">Kelly D</searchLink>; Department of Information Systems, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Gao+J%22">Gao J</searchLink>; Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Schietinger+A%22">Schietinger A</searchLink>; Weill Cornell Medical Center, New York, NY, USA.; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Hollmann+TJ%22">Hollmann TJ</searchLink>; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Bristol Myers Squibb, Princeton, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Bakhoum+SF%22">Bakhoum SF</searchLink>; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Soslow+RA%22">Soslow RA</searchLink>; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Ellenson+LH%22">Ellenson LH</searchLink>; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Abu-Rustum+NR%22">Abu-Rustum NR</searchLink>; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Weill Cornell Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Aghajanian+C%22">Aghajanian C</searchLink>; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Friedman+CF%22">Friedman CF</searchLink>; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Weill Cornell Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22McPherson+A%22">McPherson A</searchLink>; Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Weigelt+B%22">Weigelt B</searchLink>; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Zamarin+D%22">Zamarin D</searchLink>; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. zamarind@mskcc.org.; Weill Cornell Medical Center, New York, NY, USA. zamarind@mskcc.org.<br /><searchLink fieldCode="AU" term="%22Shah+SP%22">Shah SP</searchLink>; Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA. shahs3@mskcc.org. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%220410462%22">Nature</searchLink> [Nature] 2022 Dec; Vol. 612 (7941), pp. 778-786. <i>Date of Electronic Publication: </i>2022 Dec 14. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Research Support, U.S. Gov't, P.H.S.; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>0410462 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1476-4687 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200280836%22">00280836 </searchLink><i>NLM ISO Abbreviation: </i>Nature <i>Subsets: </i>MEDLINE |
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