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A prefusion-stabilized RSV F subunit vaccine elicits B cell responses with greater breadth and potency than a postfusion F vaccine.

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Title: A prefusion-stabilized RSV F subunit vaccine elicits B cell responses with greater breadth and potency than a postfusion F vaccine.
Authors: Chang LA; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA., Phung E; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA., Crank MC; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA., Morabito KM; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA., Villafana T; Vaccines and Immune Therapies, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD 20878, USA., Dubovsky F; Vaccines and Immune Therapies, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD 20878, USA., Falloon J; Vaccines and Immune Therapies, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD 20878, USA., Esser MT; Vaccines and Immune Therapies, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD 20878, USA., Lin BC; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA., Chen GL; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA., Graham BS; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA., Ruckwardt TJ; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
Source: Science translational medicine [Sci Transl Med] 2022 Dec 21; Vol. 14 (676), pp. eade0424. Date of Electronic Publication: 2022 Dec 21.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Intramural
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A prefusion-stabilized RSV F subunit vaccine elicits B cell responses with greater breadth and potency than a postfusion F vaccine.
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  Data: <searchLink fieldCode="AU" term="%22Chang+LA%22">Chang LA</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Phung+E%22">Phung E</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Crank+MC%22">Crank MC</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Morabito+KM%22">Morabito KM</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Villafana+T%22">Villafana T</searchLink>; Vaccines and Immune Therapies, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD 20878, USA.<br /><searchLink fieldCode="AU" term="%22Dubovsky+F%22">Dubovsky F</searchLink>; Vaccines and Immune Therapies, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD 20878, USA.<br /><searchLink fieldCode="AU" term="%22Falloon+J%22">Falloon J</searchLink>; Vaccines and Immune Therapies, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD 20878, USA.<br /><searchLink fieldCode="AU" term="%22Esser+MT%22">Esser MT</searchLink>; Vaccines and Immune Therapies, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD 20878, USA.<br /><searchLink fieldCode="AU" term="%22Lin+BC%22">Lin BC</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Chen+GL%22">Chen GL</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Graham+BS%22">Graham BS</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Ruckwardt+TJ%22">Ruckwardt TJ</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
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  Data: <searchLink fieldCode="JN" term="%22101505086%22">Science translational medicine</searchLink> [Sci Transl Med] 2022 Dec 21; Vol. 14 (676), pp. eade0424. <i>Date of Electronic Publication: </i>2022 Dec 21.
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  Data: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Intramural
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