Anti-SARS-CoV-2 antibody-containing plasma improves outcome in patients with hematologic or solid cancer and severe COVID-19: a randomized clinical trial.
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| Title: | Anti-SARS-CoV-2 antibody-containing plasma improves outcome in patients with hematologic or solid cancer and severe COVID-19: a randomized clinical trial. |
|---|---|
| Authors: | Denkinger CM; Division of Infectious Disease and Tropical Medicine, Department of Infectious Diseases, Heidelberg University Hospital, Heidelberg, Germany. Claudia.Denkinger@uni-heidelberg.de.; Partner site Heidelberg University Hospital, German Center for Infection Research, Heidelberg, Germany. Claudia.Denkinger@uni-heidelberg.de., Janssen M; Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany., Schäkel U; Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany., Gall J; NCT Trial Center, National Center for Tumor Diseases, Heidelberg University Hospital and German Cancer Research Center, Heidelberg, Germany., Leo A; Institute for Clinical Transfusion Medicine and Cell Therapy Heidelberg, Heidelberg, Germany., Stelmach P; Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany., Weber SF; Division of Infectious Disease and Tropical Medicine, Department of Infectious Diseases, Heidelberg University Hospital, Heidelberg, Germany., Krisam J; Institute of Medical Biometry, University of Heidelberg, Heidelberg, Germany., Baumann L; Institute of Medical Biometry, University of Heidelberg, Heidelberg, Germany., Stermann J; Institute of Medical Biometry, University of Heidelberg, Heidelberg, Germany., Merle U; Department of Internal Medicine IV, Heidelberg University Hospital, Heidelberg, Germany., Weigand MA; Department of Anesthesiology, Heidelberg University Hospital, Heidelberg, Germany., Nusshag C; Department of Nephrology, University of Heidelberg, Heidelberg, Germany., Bullinger L; Department of Hematology, Oncology and Tumor Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany., Schrezenmeier JF; Department of Hematology, Oncology and Tumor Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany., Bornhäuser M; Department of Internal Medicine I, University Hospital Dresden and Faculty of Medicine Carl Gustav Carus of TU Dresden, Dresden, Germany., Alakel N; Department of Internal Medicine I, University Hospital Dresden and Faculty of Medicine Carl Gustav Carus of TU Dresden, Dresden, Germany., Witzke O; Department of Infectious Diseases, West German Centre for Infectious Diseases, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Wolf T; Department of Internal Medicine, Infectious Diseases, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt, Germany., Vehreschild MJGT; Department of Internal Medicine, Infectious Diseases, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt, Germany., Schmiedel S; Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Addo MM; Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Partner site Hamburg-Lübeck-Borstel-Riems, German Center for Infection Research, Hamburg, Germany.; University Medical Center Hamburg-Eppendorf, Institute for Infection Research and Vaccine Development, Hamburg, Germany., Herth F; Pneumology and Critical Care Medicine, Thoraxklinik, University of Heidelberg and Translational Lung Research Center, Heidelberg, Germany., Kreuter M; Center for Interstitial and Rare Lung Diseases, Pneumology and Critical Care Medicine, Thoraxklinik, University of Heidelberg and German Center for Lung Research, Heidelberg, Germany., Tepasse PR; Department of Medicine B, Gastroenterology and Hepatology, University Hospital Münster, Münster, Germany., Hertenstein B; Medical Department I, Klinikum Bremen-Mitte, Bremen, Germany., Hänel M; Department of Internal Medicine III, Klinikum Chemnitz, Chemnitz, Germany., Morgner A; Department of Internal Medicine III, Klinikum Chemnitz, Chemnitz, Germany., Kiehl M; Department of Internal Medicine I, Frankfurt (Oder) General Hospital, Frankfurt (Oder), Germany., Hopfer O; Department of Internal Medicine I, Frankfurt (Oder) General Hospital, Frankfurt (Oder), Germany., Wattad MA; Department of Hematology, Oncology, Palliative Care and Stem Cell Transplantation, Klinikum Hochsauerland, Meschede, Germany., Schimanski CC; Department of Internal Medicine II, Klinikum Darmstadt, Darmstadt, Germany., Celik C; Department of Internal Medicine II, Klinikum Darmstadt, Darmstadt, Germany., Pohle T; Department of Internal Medicine I, Klinikum Herford, Herford, Germany., Ruhe M; Department of Internal Medicine I, Klinikum Herford, Herford, Germany., Kern WV; Department of Medicine II, Division of Infectious Diseases and Travel Medicine, University Medical Centre Freiburg, Freiburg, Germany., Schmitt A; Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany., Lorenz HM; Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany., Souto-Carneiro M; Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany., Gaeddert M; Division of Infectious Disease and Tropical Medicine, Department of Infectious Diseases, Heidelberg University Hospital, Heidelberg, Germany., Halama N; Department of Medical Oncology, National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany.; Department of Translational Immunotherapy (D240), German Cancer Research Center, Heidelberg, Germany.; Helmholtz Institute for Translational Oncology, Mainz, Germany., Meuer S; Institute for Clinical Transfusion Medicine and Cell Therapy Heidelberg, Heidelberg, Germany., Kräusslich HG; Department of Infectious Diseases, Virology, Heidelberg University Hospital, Heidelberg, Germany., Müller B; Department of Infectious Diseases, Virology, Heidelberg University Hospital, Heidelberg, Germany., Schnitzler P; Department of Infectious Diseases, Virology, Heidelberg University Hospital, Heidelberg, Germany., Parthé S; Department of Infectious Diseases, Virology, Heidelberg University Hospital, Heidelberg, Germany., Bartenschlager R; Department of Infectious Diseases, Molecular Virology, Heidelberg University Hospital, Heidelberg, Germany., Gronkowski M; Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany., Klemmer J; Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany., Schmitt M; Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany., Dreger P; Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany., Kriegsmann K; Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany., Schlenk RF; Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany.; NCT Trial Center, National Center for Tumor Diseases, Heidelberg University Hospital and German Cancer Research Center, Heidelberg, Germany.; Department of Medical Oncology, National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany., Müller-Tidow C; Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany. carsten.mueller-tidow@med.uni-heidelberg.de.; National Center for Tumor Diseases, Heidelberg, Germany. carsten.mueller-tidow@med.uni-heidelberg.de. |
| Source: | Nature cancer [Nat Cancer] 2023 Jan; Vol. 4 (1), pp. 96-107. Date of Electronic Publication: 2022 Dec 29. |
| Publication Type: | Randomized Controlled Trial; Multicenter Study; Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101761119 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2662-1347 (Electronic) Linking ISSN: 26621347 NLM ISO Abbreviation: Nat Cancer Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 36581734 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Anti-SARS-CoV-2 antibody-containing plasma improves outcome in patients with hematologic or solid cancer and severe COVID-19: a randomized clinical trial. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Denkinger+CM%22">Denkinger CM</searchLink>; Division of Infectious Disease and Tropical Medicine, Department of Infectious Diseases, Heidelberg University Hospital, Heidelberg, Germany. Claudia.Denkinger@uni-heidelberg.de.; Partner site Heidelberg University Hospital, German Center for Infection Research, Heidelberg, Germany. Claudia.Denkinger@uni-heidelberg.de.<br /><searchLink fieldCode="AU" term="%22Janssen+M%22">Janssen M</searchLink>; Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Schäkel+U%22">Schäkel U</searchLink>; Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Gall+J%22">Gall J</searchLink>; NCT Trial Center, National Center for Tumor Diseases, Heidelberg University Hospital and German Cancer Research Center, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Leo+A%22">Leo A</searchLink>; Institute for Clinical Transfusion Medicine and Cell Therapy Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Stelmach+P%22">Stelmach P</searchLink>; Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Weber+SF%22">Weber SF</searchLink>; Division of Infectious Disease and Tropical Medicine, Department of Infectious Diseases, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Krisam+J%22">Krisam J</searchLink>; Institute of Medical Biometry, University of Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Baumann+L%22">Baumann L</searchLink>; Institute of Medical Biometry, University of Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Stermann+J%22">Stermann J</searchLink>; Institute of Medical Biometry, University of Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Merle+U%22">Merle U</searchLink>; Department of Internal Medicine IV, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Weigand+MA%22">Weigand MA</searchLink>; Department of Anesthesiology, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Nusshag+C%22">Nusshag C</searchLink>; Department of Nephrology, University of Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Bullinger+L%22">Bullinger L</searchLink>; Department of Hematology, Oncology and Tumor Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Schrezenmeier+JF%22">Schrezenmeier JF</searchLink>; Department of Hematology, Oncology and Tumor Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Bornhäuser+M%22">Bornhäuser M</searchLink>; Department of Internal Medicine I, University Hospital Dresden and Faculty of Medicine Carl Gustav Carus of TU Dresden, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Alakel+N%22">Alakel N</searchLink>; Department of Internal Medicine I, University Hospital Dresden and Faculty of Medicine Carl Gustav Carus of TU Dresden, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Witzke+O%22">Witzke O</searchLink>; Department of Infectious Diseases, West German Centre for Infectious Diseases, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Wolf+T%22">Wolf T</searchLink>; Department of Internal Medicine, Infectious Diseases, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Vehreschild+MJGT%22">Vehreschild MJGT</searchLink>; Department of Internal Medicine, Infectious Diseases, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Schmiedel+S%22">Schmiedel S</searchLink>; Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Addo+MM%22">Addo MM</searchLink>; Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Partner site Hamburg-Lübeck-Borstel-Riems, German Center for Infection Research, Hamburg, Germany.; University Medical Center Hamburg-Eppendorf, Institute for Infection Research and Vaccine Development, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Herth+F%22">Herth F</searchLink>; Pneumology and Critical Care Medicine, Thoraxklinik, University of Heidelberg and Translational Lung Research Center, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Kreuter+M%22">Kreuter M</searchLink>; Center for Interstitial and Rare Lung Diseases, Pneumology and Critical Care Medicine, Thoraxklinik, University of Heidelberg and German Center for Lung Research, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Tepasse+PR%22">Tepasse PR</searchLink>; Department of Medicine B, Gastroenterology and Hepatology, University Hospital Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Hertenstein+B%22">Hertenstein B</searchLink>; Medical Department I, Klinikum Bremen-Mitte, Bremen, Germany.<br /><searchLink fieldCode="AU" term="%22Hänel+M%22">Hänel M</searchLink>; Department of Internal Medicine III, Klinikum Chemnitz, Chemnitz, Germany.<br /><searchLink fieldCode="AU" term="%22Morgner+A%22">Morgner A</searchLink>; Department of Internal Medicine III, Klinikum Chemnitz, Chemnitz, Germany.<br /><searchLink fieldCode="AU" term="%22Kiehl+M%22">Kiehl M</searchLink>; Department of Internal Medicine I, Frankfurt (Oder) General Hospital, Frankfurt (Oder), Germany.<br /><searchLink fieldCode="AU" term="%22Hopfer+O%22">Hopfer O</searchLink>; Department of Internal Medicine I, Frankfurt (Oder) General Hospital, Frankfurt (Oder), Germany.<br /><searchLink fieldCode="AU" term="%22Wattad+MA%22">Wattad MA</searchLink>; Department of Hematology, Oncology, Palliative Care and Stem Cell Transplantation, Klinikum Hochsauerland, Meschede, Germany.<br /><searchLink fieldCode="AU" term="%22Schimanski+CC%22">Schimanski CC</searchLink>; Department of Internal Medicine II, Klinikum Darmstadt, Darmstadt, Germany.<br /><searchLink fieldCode="AU" term="%22Celik+C%22">Celik C</searchLink>; Department of Internal Medicine II, Klinikum Darmstadt, Darmstadt, Germany.<br /><searchLink fieldCode="AU" term="%22Pohle+T%22">Pohle T</searchLink>; Department of Internal Medicine I, Klinikum Herford, Herford, Germany.<br /><searchLink fieldCode="AU" term="%22Ruhe+M%22">Ruhe M</searchLink>; Department of Internal Medicine I, Klinikum Herford, Herford, Germany.<br /><searchLink fieldCode="AU" term="%22Kern+WV%22">Kern WV</searchLink>; Department of Medicine II, Division of Infectious Diseases and Travel Medicine, University Medical Centre Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Schmitt+A%22">Schmitt A</searchLink>; Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Lorenz+HM%22">Lorenz HM</searchLink>; Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Souto-Carneiro+M%22">Souto-Carneiro M</searchLink>; Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Gaeddert+M%22">Gaeddert M</searchLink>; Division of Infectious Disease and Tropical Medicine, Department of Infectious Diseases, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Halama+N%22">Halama N</searchLink>; Department of Medical Oncology, National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany.; Department of Translational Immunotherapy (D240), German Cancer Research Center, Heidelberg, Germany.; Helmholtz Institute for Translational Oncology, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Meuer+S%22">Meuer S</searchLink>; Institute for Clinical Transfusion Medicine and Cell Therapy Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Kräusslich+HG%22">Kräusslich HG</searchLink>; Department of Infectious Diseases, Virology, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Müller+B%22">Müller B</searchLink>; Department of Infectious Diseases, Virology, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Schnitzler+P%22">Schnitzler P</searchLink>; Department of Infectious Diseases, Virology, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Parthé+S%22">Parthé S</searchLink>; Department of Infectious Diseases, Virology, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Bartenschlager+R%22">Bartenschlager R</searchLink>; Department of Infectious Diseases, Molecular Virology, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Gronkowski+M%22">Gronkowski M</searchLink>; Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Klemmer+J%22">Klemmer J</searchLink>; Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Schmitt+M%22">Schmitt M</searchLink>; Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Dreger+P%22">Dreger P</searchLink>; Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Kriegsmann+K%22">Kriegsmann K</searchLink>; Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Schlenk+RF%22">Schlenk RF</searchLink>; Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany.; NCT Trial Center, National Center for Tumor Diseases, Heidelberg University Hospital and German Cancer Research Center, Heidelberg, Germany.; Department of Medical Oncology, National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Müller-Tidow+C%22">Müller-Tidow C</searchLink>; Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany. carsten.mueller-tidow@med.uni-heidelberg.de.; National Center for Tumor Diseases, Heidelberg, Germany. carsten.mueller-tidow@med.uni-heidelberg.de. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101761119%22">Nature cancer</searchLink> [Nat Cancer] 2023 Jan; Vol. 4 (1), pp. 96-107. <i>Date of Electronic Publication: </i>2022 Dec 29. – Name: TypePub Label: Publication Type Group: TypPub Data: Randomized Controlled Trial; Multicenter Study; Journal Article; Research Support, Non-U.S. Gov't – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101761119 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2662-1347 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2226621347%22">26621347 </searchLink><i>NLM ISO Abbreviation: </i>Nat Cancer <i>Subsets: </i>MEDLINE |
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