The Substitutions L50F, E166A, and L167F in SARS-CoV-2 3CLpro Are Selected by a Protease Inhibitor In Vitro and Confer Resistance To Nirmatrelvir.

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Title: The Substitutions L50F, E166A, and L167F in SARS-CoV-2 3CLpro Are Selected by a Protease Inhibitor In Vitro and Confer Resistance To Nirmatrelvir.
Authors: Jochmans D; KU Leuven, Department of Microbiology, Immunology & Transplantation, Rega Institute, Laboratory of Virology & Chemotherapy, Leuven, Belgium., Liu C; Aligos Therapeutics, Inc., South San Francisco, California, USA., Donckers K; KU Leuven, Department of Microbiology, Immunology & Transplantation, Rega Institute, Laboratory of Virology & Chemotherapy, Leuven, Belgium., Stoycheva A; Aligos Therapeutics, Inc., South San Francisco, California, USA., Boland S; CISTIM Leuven vzw, Leuven, Belgium., Stevens SK; Aligos Therapeutics, Inc., South San Francisco, California, USA., De Vita C; Aligos Therapeutics, Inc., South San Francisco, California, USA., Vanmechelen B; KU Leuven, Department of Microbiology, Immunology & Transplantation, Rega Institute, Laboratory of Clinical & Epidemiological Virology, Leuven, Belgium., Maes P; KU Leuven, Department of Microbiology, Immunology & Transplantation, Rega Institute, Laboratory of Clinical & Epidemiological Virology, Leuven, Belgium., Trüeb B; Institute of Virology and Immunology, University of Bern, Bern, Switzerland., Ebert N; Institute of Virology and Immunology, University of Bern, Bern, Switzerland.; Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland., Thiel V; Institute of Virology and Immunology, University of Bern, Bern, Switzerland.; Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland., De Jonghe S; KU Leuven, Department of Microbiology, Immunology & Transplantation, Rega Institute, Laboratory of Virology & Chemotherapy, Leuven, Belgium., Vangeel L; KU Leuven, Department of Microbiology, Immunology & Transplantation, Rega Institute, Laboratory of Virology & Chemotherapy, Leuven, Belgium., Bardiot D; CISTIM Leuven vzw, Leuven, Belgium., Jekle A; Aligos Therapeutics, Inc., South San Francisco, California, USA., Blatt LM; Aligos Therapeutics, Inc., South San Francisco, California, USA., Beigelman L; Aligos Therapeutics, Inc., South San Francisco, California, USA., Symons JA; Aligos Therapeutics, Inc., South San Francisco, California, USA., Raboisson P; Aligos Belgium BV, Leuven, Belgium., Chaltin P; CISTIM Leuven vzw, Leuven, Belgium.; Centre for Drug Design and Discovery (CD3), KU Leuven, Leuven, Belgium., Marchand A; CISTIM Leuven vzw, Leuven, Belgium., Neyts J; KU Leuven, Department of Microbiology, Immunology & Transplantation, Rega Institute, Laboratory of Virology & Chemotherapy, Leuven, Belgium.; Global Virus Network (GVN), Baltimore, Maryland, USA., Deval J; Aligos Therapeutics, Inc., South San Francisco, California, USA., Vandyck K; Aligos Belgium BV, Leuven, Belgium.
Source: MBio [mBio] 2023 Feb 28; Vol. 14 (1), pp. e0281522. Date of Electronic Publication: 2023 Jan 10.
Publication Type: Journal Article
Journal Info: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 101519231 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2150-7511 (Electronic) NLM ISO Abbreviation: mBio Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2150-7511
DOI:10.1128/mbio.02815-22