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Cross-Ancestry Genome-Wide Association Study Defines the Extended CYP2D6 Locus as the Principal Genetic Determinant of Endoxifen Plasma Concentrations.

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Title: Cross-Ancestry Genome-Wide Association Study Defines the Extended CYP2D6 Locus as the Principal Genetic Determinant of Endoxifen Plasma Concentrations.
Authors: Khor CC; Division of Human Genetics, Genome Institute of Singapore, Singapore, Singapore.; Singapore Eye Research Institute, Singapore, Singapore.; Clinical Pharmacology, SingHealth, Singapore, Singapore., Winter S; Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.; University Tübingen, Tübingen, Germany., Sutiman N; Clinical Pharmacology Laboratory, Division of Cellular and Molecular Research, National Cancer Centre, Singapore, Singapore., Mürdter TE; Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.; University Tübingen, Tübingen, Germany., Chen S; Clinical Pharmacology Laboratory, Division of Cellular and Molecular Research, National Cancer Centre, Singapore, Singapore., Lim JSL; Clinical Pharmacology Laboratory, Division of Cellular and Molecular Research, National Cancer Centre, Singapore, Singapore., Li Z; Division of Human Genetics, Genome Institute of Singapore, Singapore, Singapore., Li J; Division of Human Genetics, Genome Institute of Singapore, Singapore, Singapore., Sim KS; Division of Human Genetics, Genome Institute of Singapore, Singapore, Singapore., Ganchev B; Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.; University Tübingen, Tübingen, Germany., Eccles D; Faculty of Medicine, Cancer Sciences Academic Unit and University of Southampton Clinical Trials Unit, University of Southampton, Southampton, UK.; University Hospital Southampton National Health Service Foundation Trust, Southampton, UK., Eccles B; Faculty of Medicine, Cancer Sciences Academic Unit and University of Southampton Clinical Trials Unit, University of Southampton, Southampton, UK.; University Hospital Southampton National Health Service Foundation Trust, Southampton, UK., Tapper W; Faculty of Medicine, Cancer Sciences Academic Unit and University of Southampton Clinical Trials Unit, University of Southampton, Southampton, UK.; University Hospital Southampton National Health Service Foundation Trust, Southampton, UK., Zgheib NK; Department of Pharmacology and Toxicology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon., Tfayli A; Hematology-Oncology Division, Department of Internal Medicine, Faculty of Medicine, American University of Beirut, Beirut, Lebanon., Ng RCH; Division of Medical Oncology, National Cancer Centre, Singapore, Singapore., Yap YS; Division of Medical Oncology, National Cancer Centre, Singapore, Singapore., Lim E; Division of Medical Oncology, National Cancer Centre, Singapore, Singapore., Wong M; Division of Medical Oncology, National Cancer Centre, Singapore, Singapore., Wong NS; OncoCare Cancer Centre, Mount Elizabeth Novena Medical Centre, Singapore, Singapore., Ang PCS; OncoCare Cancer Centre, Mount Elizabeth Novena Medical Centre, Singapore, Singapore., Dent R; Division of Medical Oncology, National Cancer Centre, Singapore, Singapore., Tremmel R; Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.; University Tübingen, Tübingen, Germany., Klein K; Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.; University Tübingen, Tübingen, Germany., Schaeffeler E; Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.; University Tübingen, Tübingen, Germany.; Image-Guided and Functionally Instructed Tumor Therapies Cluster of Excellence (iFIT), University of Tübingen, Tübingen, Germany., Zhou Y; Department of Laboratory Medicine, Karolinska Institute, Stockholm, Sweden., Lauschke VM; Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.; University Tübingen, Tübingen, Germany.; Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden., Eichelbaum M; Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.; University Tübingen, Tübingen, Germany., Schwab M; Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.; Image-Guided and Functionally Instructed Tumor Therapies Cluster of Excellence (iFIT), University of Tübingen, Tübingen, Germany.; Department of Clinical Pharmacology, University of Tübingen, Tübingen, Germany.; Department of Biochemistry and Pharmacy, University of Tübingen, Tübingen, Germany.; German Cancer Consortium (DKTK), German Cancer Research Center, Partner Site Tübingen, Tübingen, Germany., Brauch HB; Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.; University Tübingen, Tübingen, Germany.; Image-Guided and Functionally Instructed Tumor Therapies Cluster of Excellence (iFIT), University of Tübingen, Tübingen, Germany.; German Cancer Consortium (DKTK), German Cancer Research Center, Partner Site Tübingen, Tübingen, Germany., Chowbay B; Clinical Pharmacology, SingHealth, Singapore, Singapore.; Clinical Pharmacology Laboratory, Division of Cellular and Molecular Research, National Cancer Centre, Singapore, Singapore.; Centre for Clinician-Scientist Development, Duke-National University of Singapore Medical School, Singapore, Singapore., Schroth W; Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.; University Tübingen, Tübingen, Germany.
Source: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2023 Mar; Vol. 113 (3), pp. 712-723. Date of Electronic Publication: 2023 Jan 31.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Wiley Country of Publication: United States NLM ID: 0372741 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-6535 (Electronic) Linking ISSN: 00099236 NLM ISO Abbreviation: Clin Pharmacol Ther Subsets: MEDLINE
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  Data: Cross-Ancestry Genome-Wide Association Study Defines the Extended CYP2D6 Locus as the Principal Genetic Determinant of Endoxifen Plasma Concentrations.
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