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Targeting Menin disrupts the KMT2A/B and polycomb balance to paradoxically activate bivalent genes.

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Title: Targeting Menin disrupts the KMT2A/B and polycomb balance to paradoxically activate bivalent genes.
Authors: Sparbier CE; Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia., Gillespie A; Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia., Gomez J; Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia., Kumari N; Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia., Motazedian A; Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia., Chan KL; Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia.; Department of Clinical Haematology, Peter MacCallum Cancer Centre and Royal Melbourne Hospital, Melbourne, Victoria, Australia., Bell CC; Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia., Gilan O; Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Australian Centre for Blood Diseases, Monash University, Melbourne, Victoria, Australia., Chan YC; Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia., Popp S; The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia., Gough DJ; Department of Molecular Translational Science, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Victoria, Australia.; Centre for Cancer Research, Hudson Institute of Medical Research, Clayton, Victoria, Australia., Eckersley-Maslin MA; Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia.; Department of Anatomy and Physiology, University of Melbourne, Melbourne, Victoria, Australia., Dawson SJ; Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia.; Centre for Cancer Research, University of Melbourne, Melbourne, Victoria, Australia., Lehner PJ; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, Cambridge, UK., Sutherland KD; ACRF Cancer Biology and Stem Cells Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia., Ernst P; Section of Hematology, Oncology and Bone Marrow Transplant, Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.; Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., McGeehan GM; Syndax Pharmaceuticals, Waltham, MA, USA., Lam EYN; Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia., Burr ML; Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia. marian.burr@anu.edu.au.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia. marian.burr@anu.edu.au.; The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia. marian.burr@anu.edu.au.; Department of Anatomical Pathology, ACT Pathology, Canberra Health Services, Canberra, Australian Capital Territory, Australia. marian.burr@anu.edu.au., Dawson MA; Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia. mark.dawson@petermac.org.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia. mark.dawson@petermac.org.; Department of Clinical Haematology, Peter MacCallum Cancer Centre and Royal Melbourne Hospital, Melbourne, Victoria, Australia. mark.dawson@petermac.org.; Centre for Cancer Research, University of Melbourne, Melbourne, Victoria, Australia. mark.dawson@petermac.org.
Source: Nature cell biology [Nat Cell Biol] 2023 Feb; Vol. 25 (2), pp. 258-272. Date of Electronic Publication: 2023 Jan 12.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Macmillan Magazines Ltd Country of Publication: England NLM ID: 100890575 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4679 (Electronic) Linking ISSN: 14657392 NLM ISO Abbreviation: Nat Cell Biol Subsets: MEDLINE
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  Data: Targeting Menin disrupts the KMT2A/B and polycomb balance to paradoxically activate bivalent genes.
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  Data: <searchLink fieldCode="AU" term="%22Sparbier+CE%22">Sparbier CE</searchLink>; Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Gillespie+A%22">Gillespie A</searchLink>; Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Gomez+J%22">Gomez J</searchLink>; Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia.<br /><searchLink fieldCode="AU" term="%22Kumari+N%22">Kumari N</searchLink>; Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Motazedian+A%22">Motazedian A</searchLink>; Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Chan+KL%22">Chan KL</searchLink>; Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia.; Department of Clinical Haematology, Peter MacCallum Cancer Centre and Royal Melbourne Hospital, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Bell+CC%22">Bell CC</searchLink>; Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Gilan+O%22">Gilan O</searchLink>; Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Australian Centre for Blood Diseases, Monash University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Chan+YC%22">Chan YC</searchLink>; Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Popp+S%22">Popp S</searchLink>; The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia.<br /><searchLink fieldCode="AU" term="%22Gough+DJ%22">Gough DJ</searchLink>; Department of Molecular Translational Science, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Victoria, Australia.; Centre for Cancer Research, Hudson Institute of Medical Research, Clayton, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Eckersley-Maslin+MA%22">Eckersley-Maslin MA</searchLink>; Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia.; Department of Anatomy and Physiology, University of Melbourne, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Dawson+SJ%22">Dawson SJ</searchLink>; Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia.; Centre for Cancer Research, University of Melbourne, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Lehner+PJ%22">Lehner PJ</searchLink>; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Sutherland+KD%22">Sutherland KD</searchLink>; ACRF Cancer Biology and Stem Cells Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Ernst+P%22">Ernst P</searchLink>; Section of Hematology, Oncology and Bone Marrow Transplant, Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.; Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22McGeehan+GM%22">McGeehan GM</searchLink>; Syndax Pharmaceuticals, Waltham, MA, USA.<br /><searchLink fieldCode="AU" term="%22Lam+EYN%22">Lam EYN</searchLink>; Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Burr+ML%22">Burr ML</searchLink>; Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia. marian.burr@anu.edu.au.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia. marian.burr@anu.edu.au.; The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia. marian.burr@anu.edu.au.; Department of Anatomical Pathology, ACT Pathology, Canberra Health Services, Canberra, Australian Capital Territory, Australia. marian.burr@anu.edu.au.<br /><searchLink fieldCode="AU" term="%22Dawson+MA%22">Dawson MA</searchLink>; Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia. mark.dawson@petermac.org.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia. mark.dawson@petermac.org.; Department of Clinical Haematology, Peter MacCallum Cancer Centre and Royal Melbourne Hospital, Melbourne, Victoria, Australia. mark.dawson@petermac.org.; Centre for Cancer Research, University of Melbourne, Melbourne, Victoria, Australia. mark.dawson@petermac.org.
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  Data: <searchLink fieldCode="JN" term="%22100890575%22">Nature cell biology</searchLink> [Nat Cell Biol] 2023 Feb; Vol. 25 (2), pp. 258-272. <i>Date of Electronic Publication: </i>2023 Jan 12.
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