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ATR inhibition overcomes platinum tolerance associated with ERCC1- and p53-deficiency by inducing replication catastrophe.

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Title: ATR inhibition overcomes platinum tolerance associated with ERCC1- and p53-deficiency by inducing replication catastrophe.
Authors: Heyza JR; Department of Oncology, Wayne State University and Karmanos Cancer Institute, Detroit, MI, USA., Ekinci E; Department of Oncology, Wayne State University and Karmanos Cancer Institute, Detroit, MI, USA., Lindquist J; Department of Oncology, Wayne State University and Karmanos Cancer Institute, Detroit, MI, USA., Lei W; Department of Oncology, Wayne State University and Karmanos Cancer Institute, Detroit, MI, USA., Yunker C; Department of Oncology, Wayne State University and Karmanos Cancer Institute, Detroit, MI, USA., Vinothkumar V; Department of Oncology, Wayne State University and Karmanos Cancer Institute, Detroit, MI, USA., Rowbotham R; Department of Oncology, Wayne State University and Karmanos Cancer Institute, Detroit, MI, USA., Polin L; Department of Oncology, Wayne State University and Karmanos Cancer Institute, Detroit, MI, USA., Snider NG; Department of Oncology, Wayne State University and Karmanos Cancer Institute, Detroit, MI, USA., Van Buren E; Department of Oncology, Wayne State University and Karmanos Cancer Institute, Detroit, MI, USA., Watza D; Department of Oncology, Wayne State University and Karmanos Cancer Institute, Detroit, MI, USA., Back JB; Department of Oncology, Wayne State University and Karmanos Cancer Institute, Detroit, MI, USA., Chen W; Department of Oncology, Wayne State University and Karmanos Cancer Institute, Detroit, MI, USA., Mamdani H; Department of Oncology, Wayne State University and Karmanos Cancer Institute, Detroit, MI, USA., Schwartz AG; Department of Oncology, Wayne State University and Karmanos Cancer Institute, Detroit, MI, USA., Turchi JJ; Departments of Medicine and Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA.; NERx Biosciences, Indianapolis, IN, USA., Bepler G; Department of Oncology, Wayne State University and Karmanos Cancer Institute, Detroit, MI, USA., Patrick SM; Department of Oncology, Wayne State University and Karmanos Cancer Institute, Detroit, MI, USA.
Source: NAR cancer [NAR Cancer] 2023 Jan 11; Vol. 5 (1), pp. zcac045. Date of Electronic Publication: 2023 Jan 11 (Print Publication: 2023).
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 101769553 Publication Model: eCollection Cited Medium: Internet ISSN: 2632-8674 (Electronic) Linking ISSN: 26328674 NLM ISO Abbreviation: NAR Cancer Subsets: PubMed not MEDLINE
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  Data: ATR inhibition overcomes platinum tolerance associated with ERCC1- and p53-deficiency by inducing replication catastrophe.
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  Data: <searchLink fieldCode="AU" term="%22Heyza+JR%22">Heyza JR</searchLink>; Department of Oncology, Wayne State University and Karmanos Cancer Institute, Detroit, MI, USA.<br /><searchLink fieldCode="AU" term="%22Ekinci+E%22">Ekinci E</searchLink>; Department of Oncology, Wayne State University and Karmanos Cancer Institute, Detroit, MI, USA.<br /><searchLink fieldCode="AU" term="%22Lindquist+J%22">Lindquist J</searchLink>; Department of Oncology, Wayne State University and Karmanos Cancer Institute, Detroit, MI, USA.<br /><searchLink fieldCode="AU" term="%22Lei+W%22">Lei W</searchLink>; Department of Oncology, Wayne State University and Karmanos Cancer Institute, Detroit, MI, USA.<br /><searchLink fieldCode="AU" term="%22Yunker+C%22">Yunker C</searchLink>; Department of Oncology, Wayne State University and Karmanos Cancer Institute, Detroit, MI, USA.<br /><searchLink fieldCode="AU" term="%22Vinothkumar+V%22">Vinothkumar V</searchLink>; Department of Oncology, Wayne State University and Karmanos Cancer Institute, Detroit, MI, USA.<br /><searchLink fieldCode="AU" term="%22Rowbotham+R%22">Rowbotham R</searchLink>; Department of Oncology, Wayne State University and Karmanos Cancer Institute, Detroit, MI, USA.<br /><searchLink fieldCode="AU" term="%22Polin+L%22">Polin L</searchLink>; Department of Oncology, Wayne State University and Karmanos Cancer Institute, Detroit, MI, USA.<br /><searchLink fieldCode="AU" term="%22Snider+NG%22">Snider NG</searchLink>; Department of Oncology, Wayne State University and Karmanos Cancer Institute, Detroit, MI, USA.<br /><searchLink fieldCode="AU" term="%22Van+Buren+E%22">Van Buren E</searchLink>; Department of Oncology, Wayne State University and Karmanos Cancer Institute, Detroit, MI, USA.<br /><searchLink fieldCode="AU" term="%22Watza+D%22">Watza D</searchLink>; Department of Oncology, Wayne State University and Karmanos Cancer Institute, Detroit, MI, USA.<br /><searchLink fieldCode="AU" term="%22Back+JB%22">Back JB</searchLink>; Department of Oncology, Wayne State University and Karmanos Cancer Institute, Detroit, MI, USA.<br /><searchLink fieldCode="AU" term="%22Chen+W%22">Chen W</searchLink>; Department of Oncology, Wayne State University and Karmanos Cancer Institute, Detroit, MI, USA.<br /><searchLink fieldCode="AU" term="%22Mamdani+H%22">Mamdani H</searchLink>; Department of Oncology, Wayne State University and Karmanos Cancer Institute, Detroit, MI, USA.<br /><searchLink fieldCode="AU" term="%22Schwartz+AG%22">Schwartz AG</searchLink>; Department of Oncology, Wayne State University and Karmanos Cancer Institute, Detroit, MI, USA.<br /><searchLink fieldCode="AU" term="%22Turchi+JJ%22">Turchi JJ</searchLink>; Departments of Medicine and Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA.; NERx Biosciences, Indianapolis, IN, USA.<br /><searchLink fieldCode="AU" term="%22Bepler+G%22">Bepler G</searchLink>; Department of Oncology, Wayne State University and Karmanos Cancer Institute, Detroit, MI, USA.<br /><searchLink fieldCode="AU" term="%22Patrick+SM%22">Patrick SM</searchLink>; Department of Oncology, Wayne State University and Karmanos Cancer Institute, Detroit, MI, USA.
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