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Pancreatic cancer cells upregulate LPAR4 in response to isolation stress to promote an ECM-enriched niche and support tumour initiation.

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Title: Pancreatic cancer cells upregulate LPAR4 in response to isolation stress to promote an ECM-enriched niche and support tumour initiation.
Authors: Wu C; Department of Pathology, Moores Cancer Center, and Sanford Consortium for Regenerative Medicine at the University of California, San Diego, La Jolla, CA, USA., Rakhshandehroo T; Department of Pathology, Moores Cancer Center, and Sanford Consortium for Regenerative Medicine at the University of California, San Diego, La Jolla, CA, USA.; Department of Radiology, Dana-Farber Cancer Institute, Harvard University, Boston, MA, USA., Wettersten HI; Department of Pathology, Moores Cancer Center, and Sanford Consortium for Regenerative Medicine at the University of California, San Diego, La Jolla, CA, USA., Campos A; Department of Pathology, Moores Cancer Center, and Sanford Consortium for Regenerative Medicine at the University of California, San Diego, La Jolla, CA, USA., von Schalscha T; Department of Pathology, Moores Cancer Center, and Sanford Consortium for Regenerative Medicine at the University of California, San Diego, La Jolla, CA, USA., Jain S; Department of Pathology, Moores Cancer Center, and Sanford Consortium for Regenerative Medicine at the University of California, San Diego, La Jolla, CA, USA., Yu Z; Department of Pathology, Moores Cancer Center, and Sanford Consortium for Regenerative Medicine at the University of California, San Diego, La Jolla, CA, USA., Tan J; Department of Pathology, Moores Cancer Center, and Sanford Consortium for Regenerative Medicine at the University of California, San Diego, La Jolla, CA, USA., Mose E; Division of Surgical Oncology, Department of Surgery, Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA., Childers BG; Division of Surgical Oncology, Department of Surgery, Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA., Lowy AM; Division of Surgical Oncology, Department of Surgery, Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA., Weis SM; Department of Pathology, Moores Cancer Center, and Sanford Consortium for Regenerative Medicine at the University of California, San Diego, La Jolla, CA, USA., Cheresh DA; Department of Pathology, Moores Cancer Center, and Sanford Consortium for Regenerative Medicine at the University of California, San Diego, La Jolla, CA, USA. dcheresh@health.ucsd.edu.
Source: Nature cell biology [Nat Cell Biol] 2023 Feb; Vol. 25 (2), pp. 309-322. Date of Electronic Publication: 2023 Jan 16.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Macmillan Magazines Ltd Country of Publication: England NLM ID: 100890575 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4679 (Electronic) Linking ISSN: 14657392 NLM ISO Abbreviation: Nat Cell Biol Subsets: MEDLINE
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  Data: Pancreatic cancer cells upregulate LPAR4 in response to isolation stress to promote an ECM-enriched niche and support tumour initiation.
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  Data: <searchLink fieldCode="AU" term="%22Wu+C%22">Wu C</searchLink>; Department of Pathology, Moores Cancer Center, and Sanford Consortium for Regenerative Medicine at the University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Rakhshandehroo+T%22">Rakhshandehroo T</searchLink>; Department of Pathology, Moores Cancer Center, and Sanford Consortium for Regenerative Medicine at the University of California, San Diego, La Jolla, CA, USA.; Department of Radiology, Dana-Farber Cancer Institute, Harvard University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Wettersten+HI%22">Wettersten HI</searchLink>; Department of Pathology, Moores Cancer Center, and Sanford Consortium for Regenerative Medicine at the University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Campos+A%22">Campos A</searchLink>; Department of Pathology, Moores Cancer Center, and Sanford Consortium for Regenerative Medicine at the University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22von+Schalscha+T%22">von Schalscha T</searchLink>; Department of Pathology, Moores Cancer Center, and Sanford Consortium for Regenerative Medicine at the University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Jain+S%22">Jain S</searchLink>; Department of Pathology, Moores Cancer Center, and Sanford Consortium for Regenerative Medicine at the University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Yu+Z%22">Yu Z</searchLink>; Department of Pathology, Moores Cancer Center, and Sanford Consortium for Regenerative Medicine at the University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Tan+J%22">Tan J</searchLink>; Department of Pathology, Moores Cancer Center, and Sanford Consortium for Regenerative Medicine at the University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Mose+E%22">Mose E</searchLink>; Division of Surgical Oncology, Department of Surgery, Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Childers+BG%22">Childers BG</searchLink>; Division of Surgical Oncology, Department of Surgery, Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Lowy+AM%22">Lowy AM</searchLink>; Division of Surgical Oncology, Department of Surgery, Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Weis+SM%22">Weis SM</searchLink>; Department of Pathology, Moores Cancer Center, and Sanford Consortium for Regenerative Medicine at the University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Cheresh+DA%22">Cheresh DA</searchLink>; Department of Pathology, Moores Cancer Center, and Sanford Consortium for Regenerative Medicine at the University of California, San Diego, La Jolla, CA, USA. dcheresh@health.ucsd.edu.
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