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Effect of Early High-Flow Nasal Oxygen vs Standard Oxygen Therapy on Length of Hospital Stay in Hospitalized Children With Acute Hypoxemic Respiratory Failure: The PARIS-2 Randomized Clinical Trial.

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Title: Effect of Early High-Flow Nasal Oxygen vs Standard Oxygen Therapy on Length of Hospital Stay in Hospitalized Children With Acute Hypoxemic Respiratory Failure: The PARIS-2 Randomized Clinical Trial.
Authors: Franklin D; Children's Emergency and Critical Care Research, Gold Coast University Hospital, Southport, Australia.; Emergency Department, Gold Coast University Hospital, Southport, Australia.; Faculty of Medicine, University of Queensland, Brisbane, Australia.; Menzies Health Institute Queensland, Griffith University, Southport, Australia.; Paediatric Research in Emergency Departments International Collaborative, Melbourne, Australia., Babl FE; Paediatric Research in Emergency Departments International Collaborative, Melbourne, Australia.; Emergency Department, Royal Children's Hospital, Melbourne, Australia.; Murdoch Children's Research Institute, Melbourne, Australia.; Department of Paediatrics, Faculty of Medicine, Dentistry, and Health Sciences, University of Melbourne, Melbourne, Australia., George S; Children's Emergency and Critical Care Research, Gold Coast University Hospital, Southport, Australia.; Emergency Department, Gold Coast University Hospital, Southport, Australia.; Faculty of Medicine, University of Queensland, Brisbane, Australia.; Menzies Health Institute Queensland, Griffith University, Southport, Australia.; Paediatric Research in Emergency Departments International Collaborative, Melbourne, Australia., Oakley E; Paediatric Research in Emergency Departments International Collaborative, Melbourne, Australia.; Emergency Department, Royal Children's Hospital, Melbourne, Australia.; Murdoch Children's Research Institute, Melbourne, Australia.; Department of Paediatrics, Faculty of Medicine, Dentistry, and Health Sciences, University of Melbourne, Melbourne, Australia., Borland ML; Paediatric Research in Emergency Departments International Collaborative, Melbourne, Australia.; Emergency Medicine, Perth Children's Hospital, Nedlands, Australia.; Divisions of Emergency Medicine and Paediatrics, School of Medicine, University of Western Australia, Crawley., Neutze J; Paediatric Research in Emergency Departments International Collaborative, Melbourne, Australia.; Departments of Surgery and Paediatrics: Child and Youth Health, University of Auckland, Auckland, New Zealand.; KidzFirst Middlemore Hospital, Auckland, New Zealand., Acworth J; Paediatric Research in Emergency Departments International Collaborative, Melbourne, Australia.; Emergency Department, Queensland Children's Hospital, South Brisbane, Australia., Craig S; Paediatric Research in Emergency Departments International Collaborative, Melbourne, Australia.; Department of Paediatrics, School of Clinical Sciences, Monash University, Clayton, Australia.; Emergency Department, Monash Medical Centre, Melbourne, Australia., Jones M; Faculty of Health Sciences and Medicine, Bond University, Gold Coast, Australia., Gannon B; Centre for the Business and Economics of Health, University of Queensland, Brisbane, Australia., Shellshear D; Paediatric Research in Emergency Departments International Collaborative, Melbourne, Australia.; Emergency Department, Queensland Children's Hospital, South Brisbane, Australia., McCay H; Department of Paediatrics, Waikato Hospital, Hamilton, New Zealand., Wallace A; Departments of Surgery and Paediatrics: Child and Youth Health, University of Auckland, Auckland, New Zealand.; Department of Paediatrics, Waikato Hospital, Hamilton, New Zealand., Hoeppner T; Emergency Medicine, Perth Children's Hospital, Nedlands, Australia., Wildman M; Emergency Department, Townsville University Hospital, Douglas, Australia., Mattes J; Paediatric Respiratory and Sleep Medicine, John Hunter Children's Hospital, New Lambton Heights, Australia.; Priority Research Centre GrowUpWell, University of Newcastle, Callaghan, Australia., Pham TMT; Faculty of Medicine, University of Queensland, Brisbane, Australia., Miller L; Faculty of Medicine, University of Queensland, Brisbane, Australia., Williams A; Paediatric Research in Emergency Departments International Collaborative, Melbourne, Australia.; Emergency Department, Royal Children's Hospital, Melbourne, Australia.; Murdoch Children's Research Institute, Melbourne, Australia., O'Brien S; Paediatric Research in Emergency Departments International Collaborative, Melbourne, Australia.; Emergency Medicine, Perth Children's Hospital, Nedlands, Australia., Lawrence S; Paediatric Research in Emergency Departments International Collaborative, Melbourne, Australia.; KidzFirst Middlemore Hospital, Auckland, New Zealand., Bonisch M; Paediatric Research in Emergency Departments International Collaborative, Melbourne, Australia.; Children's Emergency Department, Starship Children's Hospital, Auckland, New Zealand., Gibbons K; Faculty of Medicine, University of Queensland, Brisbane, Australia., Moloney S; Paediatric Department, Gold Coast University Hospital, Griffith University School of Medicine, Southport, Australia., Waugh J; Paediatric Department, Ipswich General Hospital, Ipswich, Australia.; Paediatric Department, Caboolture Hospital, Caboolture, Australia., Hobbins S; Paediatric and Emergency Departments, Prince Charles Hospital, Chermside, Australia., Grew S; Paediatric Department, Redcliffe Hospital, Redcliffe, Australia., Fahy R; Paediatric and Emergency Departments, Prince Charles Hospital, Chermside, Australia., Dalziel SR; Paediatric Research in Emergency Departments International Collaborative, Melbourne, Australia.; Departments of Surgery and Paediatrics: Child and Youth Health, University of Auckland, Auckland, New Zealand.; Children's Emergency Department, Starship Children's Hospital, Auckland, New Zealand.; University of Auckland, Auckland, New Zealand., Schibler A; Paediatric Research in Emergency Departments International Collaborative, Melbourne, Australia.; St Andrew's War Memorial Hospital, Brisbane, Australia.; Critical Care Research Group, St Andrew's War Memorial Hospital, Brisbane, Australia.; Wesley Medical Research, Wesley Hospital, Auchenflower, Australia.
Source: JAMA [JAMA] 2023 Jan 17; Vol. 329 (3), pp. 224-234.
Publication Type: Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 7501160 Publication Model: Print Cited Medium: Internet ISSN: 1538-3598 (Electronic) Linking ISSN: 00987484 NLM ISO Abbreviation: JAMA Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Effect of Early High-Flow Nasal Oxygen vs Standard Oxygen Therapy on Length of Hospital Stay in Hospitalized Children With Acute Hypoxemic Respiratory Failure: The PARIS-2 Randomized Clinical Trial.
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  Data: <searchLink fieldCode="AU" term="%22Franklin+D%22">Franklin D</searchLink>; Children's Emergency and Critical Care Research, Gold Coast University Hospital, Southport, Australia.; Emergency Department, Gold Coast University Hospital, Southport, Australia.; Faculty of Medicine, University of Queensland, Brisbane, Australia.; Menzies Health Institute Queensland, Griffith University, Southport, Australia.; Paediatric Research in Emergency Departments International Collaborative, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Babl+FE%22">Babl FE</searchLink>; Paediatric Research in Emergency Departments International Collaborative, Melbourne, Australia.; Emergency Department, Royal Children's Hospital, Melbourne, Australia.; Murdoch Children's Research Institute, Melbourne, Australia.; Department of Paediatrics, Faculty of Medicine, Dentistry, and Health Sciences, University of Melbourne, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22George+S%22">George S</searchLink>; Children's Emergency and Critical Care Research, Gold Coast University Hospital, Southport, Australia.; Emergency Department, Gold Coast University Hospital, Southport, Australia.; Faculty of Medicine, University of Queensland, Brisbane, Australia.; Menzies Health Institute Queensland, Griffith University, Southport, Australia.; Paediatric Research in Emergency Departments International Collaborative, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Oakley+E%22">Oakley E</searchLink>; Paediatric Research in Emergency Departments International Collaborative, Melbourne, Australia.; Emergency Department, Royal Children's Hospital, Melbourne, Australia.; Murdoch Children's Research Institute, Melbourne, Australia.; Department of Paediatrics, Faculty of Medicine, Dentistry, and Health Sciences, University of Melbourne, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Borland+ML%22">Borland ML</searchLink>; Paediatric Research in Emergency Departments International Collaborative, Melbourne, Australia.; Emergency Medicine, Perth Children's Hospital, Nedlands, Australia.; Divisions of Emergency Medicine and Paediatrics, School of Medicine, University of Western Australia, Crawley.<br /><searchLink fieldCode="AU" term="%22Neutze+J%22">Neutze J</searchLink>; Paediatric Research in Emergency Departments International Collaborative, Melbourne, Australia.; Departments of Surgery and Paediatrics: Child and Youth Health, University of Auckland, Auckland, New Zealand.; KidzFirst Middlemore Hospital, Auckland, New Zealand.<br /><searchLink fieldCode="AU" term="%22Acworth+J%22">Acworth J</searchLink>; Paediatric Research in Emergency Departments International Collaborative, Melbourne, Australia.; Emergency Department, Queensland Children's Hospital, South Brisbane, Australia.<br /><searchLink fieldCode="AU" term="%22Craig+S%22">Craig S</searchLink>; Paediatric Research in Emergency Departments International Collaborative, Melbourne, Australia.; Department of Paediatrics, School of Clinical Sciences, Monash University, Clayton, Australia.; Emergency Department, Monash Medical Centre, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Jones+M%22">Jones M</searchLink>; Faculty of Health Sciences and Medicine, Bond University, Gold Coast, Australia.<br /><searchLink fieldCode="AU" term="%22Gannon+B%22">Gannon B</searchLink>; Centre for the Business and Economics of Health, University of Queensland, Brisbane, Australia.<br /><searchLink fieldCode="AU" term="%22Shellshear+D%22">Shellshear D</searchLink>; Paediatric Research in Emergency Departments International Collaborative, Melbourne, Australia.; Emergency Department, Queensland Children's Hospital, South Brisbane, Australia.<br /><searchLink fieldCode="AU" term="%22McCay+H%22">McCay H</searchLink>; Department of Paediatrics, Waikato Hospital, Hamilton, New Zealand.<br /><searchLink fieldCode="AU" term="%22Wallace+A%22">Wallace A</searchLink>; Departments of Surgery and Paediatrics: Child and Youth Health, University of Auckland, Auckland, New Zealand.; Department of Paediatrics, Waikato Hospital, Hamilton, New Zealand.<br /><searchLink fieldCode="AU" term="%22Hoeppner+T%22">Hoeppner T</searchLink>; Emergency Medicine, Perth Children's Hospital, Nedlands, Australia.<br /><searchLink fieldCode="AU" term="%22Wildman+M%22">Wildman M</searchLink>; Emergency Department, Townsville University Hospital, Douglas, Australia.<br /><searchLink fieldCode="AU" term="%22Mattes+J%22">Mattes J</searchLink>; Paediatric Respiratory and Sleep Medicine, John Hunter Children's Hospital, New Lambton Heights, Australia.; Priority Research Centre GrowUpWell, University of Newcastle, Callaghan, Australia.<br /><searchLink fieldCode="AU" term="%22Pham+TMT%22">Pham TMT</searchLink>; Faculty of Medicine, University of Queensland, Brisbane, Australia.<br /><searchLink fieldCode="AU" term="%22Miller+L%22">Miller L</searchLink>; Faculty of Medicine, University of Queensland, Brisbane, Australia.<br /><searchLink fieldCode="AU" term="%22Williams+A%22">Williams A</searchLink>; Paediatric Research in Emergency Departments International Collaborative, Melbourne, Australia.; Emergency Department, Royal Children's Hospital, Melbourne, Australia.; Murdoch Children's Research Institute, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22O'Brien+S%22">O'Brien S</searchLink>; Paediatric Research in Emergency Departments International Collaborative, Melbourne, Australia.; Emergency Medicine, Perth Children's Hospital, Nedlands, Australia.<br /><searchLink fieldCode="AU" term="%22Lawrence+S%22">Lawrence S</searchLink>; Paediatric Research in Emergency Departments International Collaborative, Melbourne, Australia.; KidzFirst Middlemore Hospital, Auckland, New Zealand.<br /><searchLink fieldCode="AU" term="%22Bonisch+M%22">Bonisch M</searchLink>; Paediatric Research in Emergency Departments International Collaborative, Melbourne, Australia.; Children's Emergency Department, Starship Children's Hospital, Auckland, New Zealand.<br /><searchLink fieldCode="AU" term="%22Gibbons+K%22">Gibbons K</searchLink>; Faculty of Medicine, University of Queensland, Brisbane, Australia.<br /><searchLink fieldCode="AU" term="%22Moloney+S%22">Moloney S</searchLink>; Paediatric Department, Gold Coast University Hospital, Griffith University School of Medicine, Southport, Australia.<br /><searchLink fieldCode="AU" term="%22Waugh+J%22">Waugh J</searchLink>; Paediatric Department, Ipswich General Hospital, Ipswich, Australia.; Paediatric Department, Caboolture Hospital, Caboolture, Australia.<br /><searchLink fieldCode="AU" term="%22Hobbins+S%22">Hobbins S</searchLink>; Paediatric and Emergency Departments, Prince Charles Hospital, Chermside, Australia.<br /><searchLink fieldCode="AU" term="%22Grew+S%22">Grew S</searchLink>; Paediatric Department, Redcliffe Hospital, Redcliffe, Australia.<br /><searchLink fieldCode="AU" term="%22Fahy+R%22">Fahy R</searchLink>; Paediatric and Emergency Departments, Prince Charles Hospital, Chermside, Australia.<br /><searchLink fieldCode="AU" term="%22Dalziel+SR%22">Dalziel SR</searchLink>; Paediatric Research in Emergency Departments International Collaborative, Melbourne, Australia.; Departments of Surgery and Paediatrics: Child and Youth Health, University of Auckland, Auckland, New Zealand.; Children's Emergency Department, Starship Children's Hospital, Auckland, New Zealand.; University of Auckland, Auckland, New Zealand.<br /><searchLink fieldCode="AU" term="%22Schibler+A%22">Schibler A</searchLink>; Paediatric Research in Emergency Departments International Collaborative, Melbourne, Australia.; St Andrew's War Memorial Hospital, Brisbane, Australia.; Critical Care Research Group, St Andrew's War Memorial Hospital, Brisbane, Australia.; Wesley Medical Research, Wesley Hospital, Auchenflower, Australia.
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