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Comprehensive analysis of mutational signatures reveals distinct patterns and molecular processes across 27 pediatric cancers.

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Title: Comprehensive analysis of mutational signatures reveals distinct patterns and molecular processes across 27 pediatric cancers.
Authors: Thatikonda V; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.; Global Computational Biology and Digital Sciences, Boehringer Ingelheim RCV GmbH, Vienna, Austria., Islam SMA; Department of Cellular and Molecular Medicine and Department of Bioengineering, Moores Cancer Center, UC San Diego, La Jolla, CA, USA., Autry RJ; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany., Jones BC; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.; Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany.; Pediatric Glioma Research Group, DKFZ, Heidelberg, Germany., Gröbner SN; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany., Warsow G; Omics IT and Data Management Core Facility (W610), DKFZ, Heidelberg, Germany., Hutter B; German Cancer Consortium (DKTK), Heidelberg, Germany.; Computational Oncology Group, Molecular Precision Oncology Program, National Center for Tumor Diseases (NCT) Heidelberg, DKFZ, Heidelberg, Germany.; Division of Applied Bioinformatics, DKFZ, Heidelberg, Germany., Huebschmann D; German Cancer Consortium (DKTK), Heidelberg, Germany.; Computational Oncology Group, Molecular Precision Oncology Program, National Center for Tumor Diseases (NCT) Heidelberg, DKFZ, Heidelberg, Germany.; Pattern Recognition and Digital Medicine, Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM), Heidelberg, Germany., Fröhling S; German Cancer Consortium (DKTK), Heidelberg, Germany.; Division of Translational Medical Oncology, NCT Heidelberg and DKFZ, Heidelberg, Germany., Kool M; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands., Blattner-Johnson M; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Pediatric Glioma Research Group, DKFZ, Heidelberg, Germany., Jones DTW; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.; Pediatric Glioma Research Group, DKFZ, Heidelberg, Germany., Alexandrov LB; Department of Cellular and Molecular Medicine and Department of Bioengineering, Moores Cancer Center, UC San Diego, La Jolla, CA, USA., Pfister SM; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany. s.pfister@kitz-heidelberg.de.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany. s.pfister@kitz-heidelberg.de.; German Cancer Consortium (DKTK), Heidelberg, Germany. s.pfister@kitz-heidelberg.de.; Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany. s.pfister@kitz-heidelberg.de., Jäger N; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany. n.jaeger@kitz-heidelberg.de.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany. n.jaeger@kitz-heidelberg.de.; German Cancer Consortium (DKTK), Heidelberg, Germany. n.jaeger@kitz-heidelberg.de.
Source: Nature cancer [Nat Cancer] 2023 Feb; Vol. 4 (2), pp. 276-289. Date of Electronic Publication: 2023 Jan 26.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101761119 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2662-1347 (Electronic) Linking ISSN: 26621347 NLM ISO Abbreviation: Nat Cancer Subsets: MEDLINE
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  Data: Comprehensive analysis of mutational signatures reveals distinct patterns and molecular processes across 27 pediatric cancers.
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  Data: <searchLink fieldCode="AU" term="%22Thatikonda+V%22">Thatikonda V</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.; Global Computational Biology and Digital Sciences, Boehringer Ingelheim RCV GmbH, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Islam+SMA%22">Islam SMA</searchLink>; Department of Cellular and Molecular Medicine and Department of Bioengineering, Moores Cancer Center, UC San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Autry+RJ%22">Autry RJ</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Jones+BC%22">Jones BC</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.; Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany.; Pediatric Glioma Research Group, DKFZ, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Gröbner+SN%22">Gröbner SN</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Warsow+G%22">Warsow G</searchLink>; Omics IT and Data Management Core Facility (W610), DKFZ, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Hutter+B%22">Hutter B</searchLink>; German Cancer Consortium (DKTK), Heidelberg, Germany.; Computational Oncology Group, Molecular Precision Oncology Program, National Center for Tumor Diseases (NCT) Heidelberg, DKFZ, Heidelberg, Germany.; Division of Applied Bioinformatics, DKFZ, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Huebschmann+D%22">Huebschmann D</searchLink>; German Cancer Consortium (DKTK), Heidelberg, Germany.; Computational Oncology Group, Molecular Precision Oncology Program, National Center for Tumor Diseases (NCT) Heidelberg, DKFZ, Heidelberg, Germany.; Pattern Recognition and Digital Medicine, Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Fröhling+S%22">Fröhling S</searchLink>; German Cancer Consortium (DKTK), Heidelberg, Germany.; Division of Translational Medical Oncology, NCT Heidelberg and DKFZ, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Kool+M%22">Kool M</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Blattner-Johnson+M%22">Blattner-Johnson M</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Pediatric Glioma Research Group, DKFZ, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Jones+DTW%22">Jones DTW</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.; Pediatric Glioma Research Group, DKFZ, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Alexandrov+LB%22">Alexandrov LB</searchLink>; Department of Cellular and Molecular Medicine and Department of Bioengineering, Moores Cancer Center, UC San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Pfister+SM%22">Pfister SM</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany. s.pfister@kitz-heidelberg.de.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany. s.pfister@kitz-heidelberg.de.; German Cancer Consortium (DKTK), Heidelberg, Germany. s.pfister@kitz-heidelberg.de.; Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany. s.pfister@kitz-heidelberg.de.<br /><searchLink fieldCode="AU" term="%22Jäger+N%22">Jäger N</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany. n.jaeger@kitz-heidelberg.de.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany. n.jaeger@kitz-heidelberg.de.; German Cancer Consortium (DKTK), Heidelberg, Germany. n.jaeger@kitz-heidelberg.de.
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