Phase I Study of Single-Agent Anti-Programmed Death-1 (MDX-1106) in Refractory Solid Tumors: Safety, Clinical Activity, Pharmacodynamics, and Immunologic Correlates.
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| Title: | Phase I Study of Single-Agent Anti-Programmed Death-1 (MDX-1106) in Refractory Solid Tumors: Safety, Clinical Activity, Pharmacodynamics, and Immunologic Correlates. |
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| Authors: | Brahmer JR; From the Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Henry Ford Health Systems, Detroit, MI; Carolina BioOncology Institute, Huntersville, NC; Washington University School of Medicine Siteman Cancer Center, St Louis, MO; and Medarex, Bloomsbury, NJ, and Milpitas, CA., Drake CG; From the Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Henry Ford Health Systems, Detroit, MI; Carolina BioOncology Institute, Huntersville, NC; Washington University School of Medicine Siteman Cancer Center, St Louis, MO; and Medarex, Bloomsbury, NJ, and Milpitas, CA., Wollner I; From the Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Henry Ford Health Systems, Detroit, MI; Carolina BioOncology Institute, Huntersville, NC; Washington University School of Medicine Siteman Cancer Center, St Louis, MO; and Medarex, Bloomsbury, NJ, and Milpitas, CA., Powderly JD; From the Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Henry Ford Health Systems, Detroit, MI; Carolina BioOncology Institute, Huntersville, NC; Washington University School of Medicine Siteman Cancer Center, St Louis, MO; and Medarex, Bloomsbury, NJ, and Milpitas, CA., Picus J; From the Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Henry Ford Health Systems, Detroit, MI; Carolina BioOncology Institute, Huntersville, NC; Washington University School of Medicine Siteman Cancer Center, St Louis, MO; and Medarex, Bloomsbury, NJ, and Milpitas, CA., Sharfman WH; From the Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Henry Ford Health Systems, Detroit, MI; Carolina BioOncology Institute, Huntersville, NC; Washington University School of Medicine Siteman Cancer Center, St Louis, MO; and Medarex, Bloomsbury, NJ, and Milpitas, CA., Stankevich E; From the Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Henry Ford Health Systems, Detroit, MI; Carolina BioOncology Institute, Huntersville, NC; Washington University School of Medicine Siteman Cancer Center, St Louis, MO; and Medarex, Bloomsbury, NJ, and Milpitas, CA., Pons A; From the Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Henry Ford Health Systems, Detroit, MI; Carolina BioOncology Institute, Huntersville, NC; Washington University School of Medicine Siteman Cancer Center, St Louis, MO; and Medarex, Bloomsbury, NJ, and Milpitas, CA., Salay TM; From the Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Henry Ford Health Systems, Detroit, MI; Carolina BioOncology Institute, Huntersville, NC; Washington University School of Medicine Siteman Cancer Center, St Louis, MO; and Medarex, Bloomsbury, NJ, and Milpitas, CA., McMiller TL; From the Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Henry Ford Health Systems, Detroit, MI; Carolina BioOncology Institute, Huntersville, NC; Washington University School of Medicine Siteman Cancer Center, St Louis, MO; and Medarex, Bloomsbury, NJ, and Milpitas, CA., Gilson MM; From the Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Henry Ford Health Systems, Detroit, MI; Carolina BioOncology Institute, Huntersville, NC; Washington University School of Medicine Siteman Cancer Center, St Louis, MO; and Medarex, Bloomsbury, NJ, and Milpitas, CA., Wang C; From the Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Henry Ford Health Systems, Detroit, MI; Carolina BioOncology Institute, Huntersville, NC; Washington University School of Medicine Siteman Cancer Center, St Louis, MO; and Medarex, Bloomsbury, NJ, and Milpitas, CA., Selby M; From the Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Henry Ford Health Systems, Detroit, MI; Carolina BioOncology Institute, Huntersville, NC; Washington University School of Medicine Siteman Cancer Center, St Louis, MO; and Medarex, Bloomsbury, NJ, and Milpitas, CA., Taube JM; From the Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Henry Ford Health Systems, Detroit, MI; Carolina BioOncology Institute, Huntersville, NC; Washington University School of Medicine Siteman Cancer Center, St Louis, MO; and Medarex, Bloomsbury, NJ, and Milpitas, CA., Anders R; From the Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Henry Ford Health Systems, Detroit, MI; Carolina BioOncology Institute, Huntersville, NC; Washington University School of Medicine Siteman Cancer Center, St Louis, MO; and Medarex, Bloomsbury, NJ, and Milpitas, CA., Chen L; From the Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Henry Ford Health Systems, Detroit, MI; Carolina BioOncology Institute, Huntersville, NC; Washington University School of Medicine Siteman Cancer Center, St Louis, MO; and Medarex, Bloomsbury, NJ, and Milpitas, CA., Korman AJ; From the Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Henry Ford Health Systems, Detroit, MI; Carolina BioOncology Institute, Huntersville, NC; Washington University School of Medicine Siteman Cancer Center, St Louis, MO; and Medarex, Bloomsbury, NJ, and Milpitas, CA., Pardoll DM; From the Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Henry Ford Health Systems, Detroit, MI; Carolina BioOncology Institute, Huntersville, NC; Washington University School of Medicine Siteman Cancer Center, St Louis, MO; and Medarex, Bloomsbury, NJ, and Milpitas, CA., Lowy I; From the Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Henry Ford Health Systems, Detroit, MI; Carolina BioOncology Institute, Huntersville, NC; Washington University School of Medicine Siteman Cancer Center, St Louis, MO; and Medarex, Bloomsbury, NJ, and Milpitas, CA., Topalian SL; From the Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Henry Ford Health Systems, Detroit, MI; Carolina BioOncology Institute, Huntersville, NC; Washington University School of Medicine Siteman Cancer Center, St Louis, MO; and Medarex, Bloomsbury, NJ, and Milpitas, CA. |
| Source: | Journal of clinical oncology : official journal of the American Society of Clinical Oncology [J Clin Oncol] 2023 Feb 01; Vol. 41 (4), pp. 715-723. |
| Publication Type: | Journal Article; Clinical Trial, Phase I; Research Support, Non-U.S. Gov't; Multicenter Study |
| Journal Info: | Publisher: American Society of Clinical Oncology Country of Publication: United States NLM ID: 8309333 Publication Model: Print Cited Medium: Internet ISSN: 1527-7755 (Electronic) Linking ISSN: 0732183X NLM ISO Abbreviation: J Clin Oncol Subsets: MEDLINE; PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 36706735 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Phase I Study of Single-Agent Anti-Programmed Death-1 (MDX-1106) in Refractory Solid Tumors: Safety, Clinical Activity, Pharmacodynamics, and Immunologic Correlates. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Brahmer+JR%22">Brahmer JR</searchLink>; From the Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Henry Ford Health Systems, Detroit, MI; Carolina BioOncology Institute, Huntersville, NC; Washington University School of Medicine Siteman Cancer Center, St Louis, MO; and Medarex, Bloomsbury, NJ, and Milpitas, CA.<br /><searchLink fieldCode="AU" term="%22Drake+CG%22">Drake CG</searchLink>; From the Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Henry Ford Health Systems, Detroit, MI; Carolina BioOncology Institute, Huntersville, NC; Washington University School of Medicine Siteman Cancer Center, St Louis, MO; and Medarex, Bloomsbury, NJ, and Milpitas, CA.<br /><searchLink fieldCode="AU" term="%22Wollner+I%22">Wollner I</searchLink>; From the Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Henry Ford Health Systems, Detroit, MI; Carolina BioOncology Institute, Huntersville, NC; Washington University School of Medicine Siteman Cancer Center, St Louis, MO; and Medarex, Bloomsbury, NJ, and Milpitas, CA.<br /><searchLink fieldCode="AU" term="%22Powderly+JD%22">Powderly JD</searchLink>; From the Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Henry Ford Health Systems, Detroit, MI; Carolina BioOncology Institute, Huntersville, NC; Washington University School of Medicine Siteman Cancer Center, St Louis, MO; and Medarex, Bloomsbury, NJ, and Milpitas, CA.<br /><searchLink fieldCode="AU" term="%22Picus+J%22">Picus J</searchLink>; From the Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Henry Ford Health Systems, Detroit, MI; Carolina BioOncology Institute, Huntersville, NC; Washington University School of Medicine Siteman Cancer Center, St Louis, MO; and Medarex, Bloomsbury, NJ, and Milpitas, CA.<br /><searchLink fieldCode="AU" term="%22Sharfman+WH%22">Sharfman WH</searchLink>; From the Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Henry Ford Health Systems, Detroit, MI; Carolina BioOncology Institute, Huntersville, NC; Washington University School of Medicine Siteman Cancer Center, St Louis, MO; and Medarex, Bloomsbury, NJ, and Milpitas, CA.<br /><searchLink fieldCode="AU" term="%22Stankevich+E%22">Stankevich E</searchLink>; From the Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Henry Ford Health Systems, Detroit, MI; Carolina BioOncology Institute, Huntersville, NC; Washington University School of Medicine Siteman Cancer Center, St Louis, MO; and Medarex, Bloomsbury, NJ, and Milpitas, CA.<br /><searchLink fieldCode="AU" term="%22Pons+A%22">Pons A</searchLink>; From the Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Henry Ford Health Systems, Detroit, MI; Carolina BioOncology Institute, Huntersville, NC; Washington University School of Medicine Siteman Cancer Center, St Louis, MO; and Medarex, Bloomsbury, NJ, and Milpitas, CA.<br /><searchLink fieldCode="AU" term="%22Salay+TM%22">Salay TM</searchLink>; From the Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Henry Ford Health Systems, Detroit, MI; Carolina BioOncology Institute, Huntersville, NC; Washington University School of Medicine Siteman Cancer Center, St Louis, MO; and Medarex, Bloomsbury, NJ, and Milpitas, CA.<br /><searchLink fieldCode="AU" term="%22McMiller+TL%22">McMiller TL</searchLink>; From the Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Henry Ford Health Systems, Detroit, MI; Carolina BioOncology Institute, Huntersville, NC; Washington University School of Medicine Siteman Cancer Center, St Louis, MO; and Medarex, Bloomsbury, NJ, and Milpitas, CA.<br /><searchLink fieldCode="AU" term="%22Gilson+MM%22">Gilson MM</searchLink>; From the Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Henry Ford Health Systems, Detroit, MI; Carolina BioOncology Institute, Huntersville, NC; Washington University School of Medicine Siteman Cancer Center, St Louis, MO; and Medarex, Bloomsbury, NJ, and Milpitas, CA.<br /><searchLink fieldCode="AU" term="%22Wang+C%22">Wang C</searchLink>; From the Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Henry Ford Health Systems, Detroit, MI; Carolina BioOncology Institute, Huntersville, NC; Washington University School of Medicine Siteman Cancer Center, St Louis, MO; and Medarex, Bloomsbury, NJ, and Milpitas, CA.<br /><searchLink fieldCode="AU" term="%22Selby+M%22">Selby M</searchLink>; From the Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Henry Ford Health Systems, Detroit, MI; Carolina BioOncology Institute, Huntersville, NC; Washington University School of Medicine Siteman Cancer Center, St Louis, MO; and Medarex, Bloomsbury, NJ, and Milpitas, CA.<br /><searchLink fieldCode="AU" term="%22Taube+JM%22">Taube JM</searchLink>; From the Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Henry Ford Health Systems, Detroit, MI; Carolina BioOncology Institute, Huntersville, NC; Washington University School of Medicine Siteman Cancer Center, St Louis, MO; and Medarex, Bloomsbury, NJ, and Milpitas, CA.<br /><searchLink fieldCode="AU" term="%22Anders+R%22">Anders R</searchLink>; From the Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Henry Ford Health Systems, Detroit, MI; Carolina BioOncology Institute, Huntersville, NC; Washington University School of Medicine Siteman Cancer Center, St Louis, MO; and Medarex, Bloomsbury, NJ, and Milpitas, CA.<br /><searchLink fieldCode="AU" term="%22Chen+L%22">Chen L</searchLink>; From the Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Henry Ford Health Systems, Detroit, MI; Carolina BioOncology Institute, Huntersville, NC; Washington University School of Medicine Siteman Cancer Center, St Louis, MO; and Medarex, Bloomsbury, NJ, and Milpitas, CA.<br /><searchLink fieldCode="AU" term="%22Korman+AJ%22">Korman AJ</searchLink>; From the Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Henry Ford Health Systems, Detroit, MI; Carolina BioOncology Institute, Huntersville, NC; Washington University School of Medicine Siteman Cancer Center, St Louis, MO; and Medarex, Bloomsbury, NJ, and Milpitas, CA.<br /><searchLink fieldCode="AU" term="%22Pardoll+DM%22">Pardoll DM</searchLink>; From the Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Henry Ford Health Systems, Detroit, MI; Carolina BioOncology Institute, Huntersville, NC; Washington University School of Medicine Siteman Cancer Center, St Louis, MO; and Medarex, Bloomsbury, NJ, and Milpitas, CA.<br /><searchLink fieldCode="AU" term="%22Lowy+I%22">Lowy I</searchLink>; From the Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Henry Ford Health Systems, Detroit, MI; Carolina BioOncology Institute, Huntersville, NC; Washington University School of Medicine Siteman Cancer Center, St Louis, MO; and Medarex, Bloomsbury, NJ, and Milpitas, CA.<br /><searchLink fieldCode="AU" term="%22Topalian+SL%22">Topalian SL</searchLink>; From the Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Henry Ford Health Systems, Detroit, MI; Carolina BioOncology Institute, Huntersville, NC; Washington University School of Medicine Siteman Cancer Center, St Louis, MO; and Medarex, Bloomsbury, NJ, and Milpitas, CA. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%228309333%22">Journal of clinical oncology : official journal of the American Society of Clinical Oncology</searchLink> [J Clin Oncol] 2023 Feb 01; Vol. 41 (4), pp. 715-723. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Clinical Trial, Phase I; Research Support, Non-U.S. Gov't; Multicenter Study – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Society+of+Clinical+Oncology%22">American Society of Clinical Oncology </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>8309333 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1527-7755 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%220732183X%22">0732183X </searchLink><i>NLM ISO Abbreviation: </i>J Clin Oncol <i>Subsets: </i>MEDLINE; PubMed not MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=36706735 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1200/JCO.22.02270 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 715 Titles: – TitleFull: Phase I Study of Single-Agent Anti-Programmed Death-1 (MDX-1106) in Refractory Solid Tumors: Safety, Clinical Activity, Pharmacodynamics, and Immunologic Correlates. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Brahmer JR – PersonEntity: Name: NameFull: Drake CG – PersonEntity: Name: NameFull: Wollner I – PersonEntity: Name: NameFull: Powderly JD – PersonEntity: Name: NameFull: Picus J – PersonEntity: Name: NameFull: Sharfman WH – PersonEntity: Name: NameFull: Stankevich E – PersonEntity: Name: NameFull: Pons A – PersonEntity: Name: NameFull: Salay TM – PersonEntity: Name: NameFull: McMiller TL – PersonEntity: Name: NameFull: Gilson MM – PersonEntity: Name: NameFull: Wang C – PersonEntity: Name: NameFull: Selby M – PersonEntity: Name: NameFull: Taube JM – PersonEntity: Name: NameFull: Anders R – PersonEntity: Name: NameFull: Chen L – PersonEntity: Name: NameFull: Korman AJ – PersonEntity: Name: NameFull: Pardoll DM – PersonEntity: Name: NameFull: Lowy I – PersonEntity: Name: NameFull: Topalian SL IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 02 Text: 2023 Feb 01 Type: published Y: 2023 Identifiers: – Type: issn-electronic Value: 1527-7755 Numbering: – Type: volume Value: 41 – Type: issue Value: 4 Titles: – TitleFull: Journal of clinical oncology : official journal of the American Society of Clinical Oncology Type: main |
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