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Potent Long-Acting Inhibitors Targeting the HIV-1 Capsid Based on a Versatile Quinazolin-4-one Scaffold.

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Title: Potent Long-Acting Inhibitors Targeting the HIV-1 Capsid Based on a Versatile Quinazolin-4-one Scaffold.
Authors: Gillis EP; Discovery Chemistry, ViiV Healthcare, Branford, Connecticut 06405, United States., Parcella K; Discovery Chemistry, ViiV Healthcare, Branford, Connecticut 06405, United States., Bowsher M; Discovery Chemistry, ViiV Healthcare, Branford, Connecticut 06405, United States., Cook JH; Discovery Chemistry, ViiV Healthcare, Branford, Connecticut 06405, United States., Iwuagwu C; Discovery Chemistry, ViiV Healthcare, Branford, Connecticut 06405, United States., Naidu BN; Discovery Chemistry, ViiV Healthcare, Branford, Connecticut 06405, United States., Patel M; Discovery Chemistry, ViiV Healthcare, Branford, Connecticut 06405, United States., Peese K; Discovery Chemistry, ViiV Healthcare, Branford, Connecticut 06405, United States., Huang H; Discovery Biology, ViiV Healthcare, Branford, Connecticut 06405, United States., Valera L; Discovery Biology, ViiV Healthcare, Branford, Connecticut 06405, United States., Wang C; Discovery Biology, ViiV Healthcare, Branford, Connecticut 06405, United States., Kieltyka K; Discovery Pharmaceutics, DMPK and Toxicology, ViiV Healthcare, Branford, Connecticut 06405, United States., Parker DD; Discovery Pharmaceutics, DMPK and Toxicology, ViiV Healthcare, Branford, Connecticut 06405, United States., Simmermacher J; Discovery Pharmaceutics, DMPK and Toxicology, ViiV Healthcare, Branford, Connecticut 06405, United States., Arnoult E; Molecular Design, GSK, Collegeville, Pennsylvania 19426, United States., Nolte RT; Protein Cellular and Structural Sciences, GSK, Collegeville, Pennsylvania 19426, United States., Wang L; Protein Cellular and Structural Sciences, GSK, Collegeville, Pennsylvania 19426, United States., Bender JA; Small Molecule Drug Discovery, Bristol Myers Squibb Research and Early Development, Princeton, New Jersey 08543, United States., Frennesson DB; Small Molecule Drug Discovery, Bristol Myers Squibb Research and Early Development, Cambridge, Massachusetts 02142, United States., Saulnier M; Small Molecule Drug Discovery, Bristol Myers Squibb Research and Early Development, Princeton, New Jersey 08543, United States., Wang AX; Small Molecule Drug Discovery, Bristol Myers Squibb Research and Early Development, Princeton, New Jersey 08543, United States., Meanwell NA; Small Molecule Drug Discovery, Bristol Myers Squibb Research and Early Development, Princeton, New Jersey 08543, United States., Belema M; Small Molecule Drug Discovery, Bristol Myers Squibb Research and Early Development, Princeton, New Jersey 08543, United States., Hanumegowda U; Discovery Pharmaceutics, DMPK and Toxicology, ViiV Healthcare, Branford, Connecticut 06405, United States.; ViiV Discovery, ViiV Healthcare, Branford, Connecticut 06405, United States., Jenkins S; Discovery Pharmaceutics, DMPK and Toxicology, ViiV Healthcare, Branford, Connecticut 06405, United States., Krystal M; Discovery Biology, ViiV Healthcare, Branford, Connecticut 06405, United States., Kadow JF; Discovery Chemistry, ViiV Healthcare, Branford, Connecticut 06405, United States., Cockett M; ViiV Discovery, ViiV Healthcare, Branford, Connecticut 06405, United States., Fridell R; Discovery Biology, ViiV Healthcare, Branford, Connecticut 06405, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2023 Feb 09; Vol. 66 (3), pp. 1941-1954. Date of Electronic Publication: 2023 Jan 31.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
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Discovery Chemistry, ViiV Healthcare, Branford, Connecticut 06405, United States.<br /><searchLink fieldCode="AU" term="%22Peese+K%22">Peese K</searchLink>; Discovery Chemistry, ViiV Healthcare, Branford, Connecticut 06405, United States.<br /><searchLink fieldCode="AU" term="%22Huang+H%22">Huang H</searchLink>; Discovery Biology, ViiV Healthcare, Branford, Connecticut 06405, United States.<br /><searchLink fieldCode="AU" term="%22Valera+L%22">Valera L</searchLink>; Discovery Biology, ViiV Healthcare, Branford, Connecticut 06405, United States.<br /><searchLink fieldCode="AU" term="%22Wang+C%22">Wang C</searchLink>; Discovery Biology, ViiV Healthcare, Branford, Connecticut 06405, United States.<br /><searchLink fieldCode="AU" term="%22Kieltyka+K%22">Kieltyka K</searchLink>; Discovery Pharmaceutics, DMPK and Toxicology, ViiV Healthcare, Branford, Connecticut 06405, United States.<br /><searchLink fieldCode="AU" term="%22Parker+DD%22">Parker DD</searchLink>; Discovery Pharmaceutics, DMPK and Toxicology, ViiV Healthcare, Branford, Connecticut 06405, United States.<br /><searchLink fieldCode="AU" term="%22Simmermacher+J%22">Simmermacher J</searchLink>; 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Small Molecule Drug Discovery, Bristol Myers Squibb Research and Early Development, Princeton, New Jersey 08543, United States.<br /><searchLink fieldCode="AU" term="%22Wang+AX%22">Wang AX</searchLink>; Small Molecule Drug Discovery, Bristol Myers Squibb Research and Early Development, Princeton, New Jersey 08543, United States.<br /><searchLink fieldCode="AU" term="%22Meanwell+NA%22">Meanwell NA</searchLink>; Small Molecule Drug Discovery, Bristol Myers Squibb Research and Early Development, Princeton, New Jersey 08543, United States.<br /><searchLink fieldCode="AU" term="%22Belema+M%22">Belema M</searchLink>; Small Molecule Drug Discovery, Bristol Myers Squibb Research and Early Development, Princeton, New Jersey 08543, United States.<br /><searchLink fieldCode="AU" term="%22Hanumegowda+U%22">Hanumegowda U</searchLink>; Discovery Pharmaceutics, DMPK and Toxicology, ViiV Healthcare, Branford, Connecticut 06405, United States.; ViiV Discovery, ViiV Healthcare, Branford, Connecticut 06405, United States.<br /><searchLink fieldCode="AU" term="%22Jenkins+S%22">Jenkins S</searchLink>; 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  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2023 Feb 09; Vol. 66 (3), pp. 1941-1954. <i>Date of Electronic Publication: </i>2023 Jan 31.
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        Value: 10.1021/acs.jmedchem.2c01732
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