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Comparison of Pyrrolobenzodiazepine Dimer Bis-imine versus Mono-imine: DNA Interstrand Cross-linking, Cytotoxicity, Antibody-Drug Conjugate Efficacy and Toxicity.

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Title: Comparison of Pyrrolobenzodiazepine Dimer Bis-imine versus Mono-imine: DNA Interstrand Cross-linking, Cytotoxicity, Antibody-Drug Conjugate Efficacy and Toxicity.
Authors: Tiberghien AC; Tumor Targeted Delivery, Oncology R&D, AstraZeneca, London, United Kingdom., Vijayakrishnan B; Tumor Targeted Delivery, Oncology R&D, AstraZeneca, London, United Kingdom., Esfandiari A; Cancer Research UK, Drug DNA Interactions Research Group, UCL Cancer Institute, London, United Kingdom., Ahmed M; Tumor Targeted Delivery, Oncology R&D, AstraZeneca, London, United Kingdom., Pardo R; Tumor Targeted Delivery, Oncology R&D, AstraZeneca, London, United Kingdom., Bingham J; Cancer Research UK, Drug DNA Interactions Research Group, UCL Cancer Institute, London, United Kingdom., Adams L; Tumor Targeted Delivery, Oncology R&D, AstraZeneca, London, United Kingdom., Santos K; Tumor Targeted Delivery, Oncology R&D, AstraZeneca, London, United Kingdom., Kang GD; Tumor Targeted Delivery, Oncology R&D, AstraZeneca, London, United Kingdom., Pugh KM; Tumor Targeted Delivery, Oncology R&D, AstraZeneca, London, United Kingdom., Afif-Rider S; Clinical Pharmacology & Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, Maryland., Vashisht K; Clinical Pharmacology & Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, Maryland., Haque K; Clinical Pharmacology & Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, Maryland., Tammali R; Tumor Targeted Delivery, Oncology R&D, AstraZeneca, Gaithersburg, Maryland., Rosfjord E; Tumor Targeted Delivery, Oncology R&D, AstraZeneca, Gaithersburg, Maryland., Savoca A; Clinical Pharmacology & Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, Maryland.; Drug Metabolism and Pharmacokinetics, Oncology R&D, AstraZeneca, Cambridge, United Kingdom., Hartley JA; Cancer Research UK, Drug DNA Interactions Research Group, UCL Cancer Institute, London, United Kingdom., Howard PW; Tumor Targeted Delivery, Oncology R&D, AstraZeneca, London, United Kingdom.
Source: Molecular cancer therapeutics [Mol Cancer Ther] 2023 Feb 01; Vol. 22 (2), pp. 254-263.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for Cancer Research, Inc Country of Publication: United States NLM ID: 101132535 Publication Model: Print Cited Medium: Internet ISSN: 1538-8514 (Electronic) Linking ISSN: 15357163 NLM ISO Abbreviation: Mol Cancer Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1538-8514
DOI:10.1158/1535-7163.MCT-21-0693