Multi-region sampling with paired sample sequencing analyses reveals sub-groups of patients with novel patient-specific dysregulation in Hepatocellular Carcinoma.

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Title: Multi-region sampling with paired sample sequencing analyses reveals sub-groups of patients with novel patient-specific dysregulation in Hepatocellular Carcinoma.
Authors: Jeon AJ; Department of Hepatopancreatobiliary and Transplant Surgery, Division of Surgery and Surgical Oncology, Singapore General Hospital and National Cancer Centre Singapore, Singapore, Singapore.; Program in Clinical and Translational Liver Cancer Research, Division of Medical Science, National Cancer Center Singapore, Singapore, Singapore., Teo YY; Department of Hepatopancreatobiliary and Transplant Surgery, Division of Surgery and Surgical Oncology, Singapore General Hospital and National Cancer Centre Singapore, Singapore, Singapore.; Program in Clinical and Translational Liver Cancer Research, Division of Medical Science, National Cancer Center Singapore, Singapore, Singapore., Sekar K; Department of Hepatopancreatobiliary and Transplant Surgery, Division of Surgery and Surgical Oncology, Singapore General Hospital and National Cancer Centre Singapore, Singapore, Singapore.; Program in Clinical and Translational Liver Cancer Research, Division of Medical Science, National Cancer Center Singapore, Singapore, Singapore., Chong SL; Department of Hepatopancreatobiliary and Transplant Surgery, Division of Surgery and Surgical Oncology, Singapore General Hospital and National Cancer Centre Singapore, Singapore, Singapore.; Program in Clinical and Translational Liver Cancer Research, Division of Medical Science, National Cancer Center Singapore, Singapore, Singapore., Wu L; Department of Hepatopancreatobiliary and Transplant Surgery, Division of Surgery and Surgical Oncology, Singapore General Hospital and National Cancer Centre Singapore, Singapore, Singapore.; Program in Clinical and Translational Liver Cancer Research, Division of Medical Science, National Cancer Center Singapore, Singapore, Singapore., Chew SC; Department of Hepatopancreatobiliary and Transplant Surgery, Division of Surgery and Surgical Oncology, Singapore General Hospital and National Cancer Centre Singapore, Singapore, Singapore.; Program in Clinical and Translational Liver Cancer Research, Division of Medical Science, National Cancer Center Singapore, Singapore, Singapore., Chen J; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Kendarsari RI; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Lai H; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Ling WH; Department of Hepatopancreatobiliary and Transplant Surgery, Division of Surgery and Surgical Oncology, Singapore General Hospital and National Cancer Centre Singapore, Singapore, Singapore.; Program in Clinical and Translational Liver Cancer Research, Division of Medical Science, National Cancer Center Singapore, Singapore, Singapore., Kaya NA; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Lim JQ; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Ramasamy A; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Oguz G; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Chung AY; Department of Hepatopancreatobiliary and Transplant Surgery, Division of Surgery and Surgical Oncology, Singapore General Hospital and National Cancer Centre Singapore, Singapore, Singapore.; Academic Clinical Programme for Surgery, Duke-NUS Medical School, Singapore, Singapore., Chan CY; Department of Hepatopancreatobiliary and Transplant Surgery, Division of Surgery and Surgical Oncology, Singapore General Hospital and National Cancer Centre Singapore, Singapore, Singapore.; Academic Clinical Programme for Surgery, Duke-NUS Medical School, Singapore, Singapore., Cheow PC; Department of Hepatopancreatobiliary and Transplant Surgery, Division of Surgery and Surgical Oncology, Singapore General Hospital and National Cancer Centre Singapore, Singapore, Singapore.; Academic Clinical Programme for Surgery, Duke-NUS Medical School, Singapore, Singapore., Kam JH; Department of Hepatopancreatobiliary and Transplant Surgery, Division of Surgery and Surgical Oncology, Singapore General Hospital and National Cancer Centre Singapore, Singapore, Singapore.; Academic Clinical Programme for Surgery, Duke-NUS Medical School, Singapore, Singapore., Madhavan K; Division of Hepatobiliary & Pancreatic Surgery, Department of Surgery, University Surgical Cluster, National University Health System, Singapore, Singapore., Kow A; Division of Hepatobiliary & Pancreatic Surgery, Department of Surgery, University Surgical Cluster, National University Health System, Singapore, Singapore., Ganpathi IS; Division of Hepatobiliary & Pancreatic Surgery, Department of Surgery, University Surgical Cluster, National University Health System, Singapore, Singapore., Lim TKH; Department of Anatomical Pathology, Singapore General Hospital, Singapore, 169608, Singapore., Leow WQ; Department of Anatomical Pathology, Singapore General Hospital, Singapore, 169608, Singapore., Loong S; Department of Anatomical Pathology, Singapore General Hospital, Singapore, 169608, Singapore., Loh TJ; Department of Anatomical Pathology, Singapore General Hospital, Singapore, 169608, Singapore., Wan WK; Department of Anatomical Pathology, Singapore General Hospital, Singapore, 169608, Singapore., Soon GST; Department of Pathology, National University Hospital, Singapore, 119074, Singapore., Pang YH; Department of Pathology, National University Hospital, Singapore, 119074, Singapore., Yoong BK; Department of Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia., Ong DB; Department of Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia., Lim J; Department of Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia., de Villa VH; Department of Surgery and Center for Liver Health and Transplantation, The Medical City, Pasig City, Metro Manila, Philippines., Cruz RDD; Department of Laboratory Medicine and Pathology, The Medical City, Pasig City, Metro Manila, Philippines., Chanwat R; Hepato-Pancreato-Biliary Surgery Unit, Department of Surgery, National Cancer Institute, Bangkok, Thailand., Thammasiri J; Division of Pathology, National Cancer Institute, Bangkok, Thailand., Bonney GK; Division of Hepatobiliary & Pancreatic Surgery, Department of Surgery, University Surgical Cluster, National University Health System, Singapore, Singapore., Goh BKP; Department of Hepatopancreatobiliary and Transplant Surgery, Division of Surgery and Surgical Oncology, Singapore General Hospital and National Cancer Centre Singapore, Singapore, Singapore.; Academic Clinical Programme for Surgery, Duke-NUS Medical School, Singapore, Singapore., Tucker-Kellogg G; Department of Biological Sciences, National University of Singapore, Singapore, Singapore., Foo RSY; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; Cardiovascular Disease Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Cardiovascular Research Institute, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Chow PKH; Department of Hepatopancreatobiliary and Transplant Surgery, Division of Surgery and Surgical Oncology, Singapore General Hospital and National Cancer Centre Singapore, Singapore, Singapore. pierce.chow@duke-nus.edu.sg.; Program in Clinical and Translational Liver Cancer Research, Division of Medical Science, National Cancer Center Singapore, Singapore, Singapore. pierce.chow@duke-nus.edu.sg.; Academic Clinical Programme for Surgery, Duke-NUS Medical School, Singapore, Singapore. pierce.chow@duke-nus.edu.sg.
Source: BMC cancer [BMC Cancer] 2023 Feb 03; Vol. 23 (1), pp. 118. Date of Electronic Publication: 2023 Feb 03.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 100967800 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2407 (Electronic) Linking ISSN: 14712407 NLM ISO Abbreviation: BMC Cancer Subsets: MEDLINE
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  Data: Multi-region sampling with paired sample sequencing analyses reveals sub-groups of patients with novel patient-specific dysregulation in Hepatocellular Carcinoma.
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  Data: <searchLink fieldCode="AU" term="%22Jeon+AJ%22">Jeon AJ</searchLink>; Department of Hepatopancreatobiliary and Transplant Surgery, Division of Surgery and Surgical Oncology, Singapore General Hospital and National Cancer Centre Singapore, Singapore, Singapore.; Program in Clinical and Translational Liver Cancer Research, Division of Medical Science, National Cancer Center Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Teo+YY%22">Teo YY</searchLink>; Department of Hepatopancreatobiliary and Transplant Surgery, Division of Surgery and Surgical Oncology, Singapore General Hospital and National Cancer Centre Singapore, Singapore, Singapore.; Program in Clinical and Translational Liver Cancer Research, Division of Medical Science, National Cancer Center Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Sekar+K%22">Sekar K</searchLink>; Department of Hepatopancreatobiliary and Transplant Surgery, Division of Surgery and Surgical Oncology, Singapore General Hospital and National Cancer Centre Singapore, Singapore, Singapore.; 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Program in Clinical and Translational Liver Cancer Research, Division of Medical Science, National Cancer Center Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Kaya+NA%22">Kaya NA</searchLink>; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Lim+JQ%22">Lim JQ</searchLink>; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Ramasamy+A%22">Ramasamy A</searchLink>; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Oguz+G%22">Oguz G</searchLink>; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Chung+AY%22">Chung AY</searchLink>; Department of Hepatopancreatobiliary and Transplant Surgery, Division of Surgery and Surgical Oncology, Singapore General Hospital and National Cancer Centre Singapore, Singapore, Singapore.; Academic Clinical Programme for Surgery, Duke-NUS Medical School, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Chan+CY%22">Chan CY</searchLink>; Department of Hepatopancreatobiliary and Transplant Surgery, Division of Surgery and Surgical Oncology, Singapore General Hospital and National Cancer Centre Singapore, Singapore, Singapore.; Academic Clinical Programme for Surgery, Duke-NUS Medical School, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Cheow+PC%22">Cheow PC</searchLink>; Department of Hepatopancreatobiliary and Transplant Surgery, Division of Surgery and Surgical Oncology, Singapore General Hospital and National Cancer Centre Singapore, Singapore, Singapore.; Academic Clinical Programme for Surgery, Duke-NUS Medical School, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Kam+JH%22">Kam JH</searchLink>; Department of Hepatopancreatobiliary and Transplant Surgery, Division of Surgery and Surgical Oncology, Singapore General Hospital and National Cancer Centre Singapore, Singapore, Singapore.; 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Division of Hepatobiliary & Pancreatic Surgery, Department of Surgery, University Surgical Cluster, National University Health System, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Goh+BKP%22">Goh BKP</searchLink>; Department of Hepatopancreatobiliary and Transplant Surgery, Division of Surgery and Surgical Oncology, Singapore General Hospital and National Cancer Centre Singapore, Singapore, Singapore.; Academic Clinical Programme for Surgery, Duke-NUS Medical School, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Tucker-Kellogg+G%22">Tucker-Kellogg G</searchLink>; Department of Biological Sciences, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Foo+RSY%22">Foo RSY</searchLink>; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; Cardiovascular Disease Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Cardiovascular Research Institute, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Chow+PKH%22">Chow PKH</searchLink>; Department of Hepatopancreatobiliary and Transplant Surgery, Division of Surgery and Surgical Oncology, Singapore General Hospital and National Cancer Centre Singapore, Singapore, Singapore. pierce.chow@duke-nus.edu.sg.; Program in Clinical and Translational Liver Cancer Research, Division of Medical Science, National Cancer Center Singapore, Singapore, Singapore. pierce.chow@duke-nus.edu.sg.; Academic Clinical Programme for Surgery, Duke-NUS Medical School, Singapore, Singapore. pierce.chow@duke-nus.edu.sg.
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