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The Drug-Induced Interface That Drives HIV-1 Integrase Hypermultimerization and Loss of Function.

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Title: The Drug-Induced Interface That Drives HIV-1 Integrase Hypermultimerization and Loss of Function.
Authors: Singer MR; Chromatin Structure & Mobile DNA Laboratory, The Francis Crick Institute, London, United Kingdom., Dinh T; Division of Infectious Diseases, School of Medicine, University of Colorado, Aurora, Colorado, USA., Levintov L; Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware, USA., Annamalai AS; Division of Infectious Diseases, School of Medicine, University of Colorado, Aurora, Colorado, USA., Rey JS; Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware, USA., Briganti L; Division of Infectious Diseases, School of Medicine, University of Colorado, Aurora, Colorado, USA., Cook NJ; Chromatin Structure & Mobile DNA Laboratory, The Francis Crick Institute, London, United Kingdom., Pye VE; Chromatin Structure & Mobile DNA Laboratory, The Francis Crick Institute, London, United Kingdom., Taylor IA; Macromolecular Structure Laboratory, The Francis Crick Institute, London, United Kingdom., Kim K; ST Pharm Co. Ltd., Seoul, South Korea., Engelman AN; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA., Kim B; Center for Drug Discovery, Children's Healthcare of Atlanta, Atlanta, Georgia, USA.; Department of Pediatrics, School of Medicine, Emory University, Atlanta, Georgia, USA., Perilla JR; Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware, USA., Kvaratskhelia M; Division of Infectious Diseases, School of Medicine, University of Colorado, Aurora, Colorado, USA., Cherepanov P; Chromatin Structure & Mobile DNA Laboratory, The Francis Crick Institute, London, United Kingdom.; Department of Infectious Disease, St-Mary's Campus, Imperial College London, London, United Kingdom.
Source: MBio [mBio] 2023 Feb 28; Vol. 14 (1), pp. e0356022. Date of Electronic Publication: 2023 Feb 06.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 101519231 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2150-7511 (Electronic) NLM ISO Abbreviation: mBio Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Singer+MR%22">Singer MR</searchLink>; Chromatin Structure & Mobile DNA Laboratory, The Francis Crick Institute, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Dinh+T%22">Dinh T</searchLink>; Division of Infectious Diseases, School of Medicine, University of Colorado, Aurora, Colorado, USA.<br /><searchLink fieldCode="AU" term="%22Levintov+L%22">Levintov L</searchLink>; Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware, USA.<br /><searchLink fieldCode="AU" term="%22Annamalai+AS%22">Annamalai AS</searchLink>; Division of Infectious Diseases, School of Medicine, University of Colorado, Aurora, Colorado, USA.<br /><searchLink fieldCode="AU" term="%22Rey+JS%22">Rey JS</searchLink>; Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware, USA.<br /><searchLink fieldCode="AU" term="%22Briganti+L%22">Briganti L</searchLink>; Division of Infectious Diseases, School of Medicine, University of Colorado, Aurora, Colorado, USA.<br /><searchLink fieldCode="AU" term="%22Cook+NJ%22">Cook NJ</searchLink>; Chromatin Structure & Mobile DNA Laboratory, The Francis Crick Institute, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Pye+VE%22">Pye VE</searchLink>; Chromatin Structure & Mobile DNA Laboratory, The Francis Crick Institute, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Taylor+IA%22">Taylor IA</searchLink>; Macromolecular Structure Laboratory, The Francis Crick Institute, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Kim+K%22">Kim K</searchLink>; ST Pharm Co. Ltd., Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Engelman+AN%22">Engelman AN</searchLink>; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Kim+B%22">Kim B</searchLink>; Center for Drug Discovery, Children's Healthcare of Atlanta, Atlanta, Georgia, USA.; Department of Pediatrics, School of Medicine, Emory University, Atlanta, Georgia, USA.<br /><searchLink fieldCode="AU" term="%22Perilla+JR%22">Perilla JR</searchLink>; Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware, USA.<br /><searchLink fieldCode="AU" term="%22Kvaratskhelia+M%22">Kvaratskhelia M</searchLink>; Division of Infectious Diseases, School of Medicine, University of Colorado, Aurora, Colorado, USA.<br /><searchLink fieldCode="AU" term="%22Cherepanov+P%22">Cherepanov P</searchLink>; Chromatin Structure & Mobile DNA Laboratory, The Francis Crick Institute, London, United Kingdom.; Department of Infectious Disease, St-Mary's Campus, Imperial College London, London, United Kingdom.
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  Data: <searchLink fieldCode="JN" term="%22101519231%22">MBio</searchLink> [mBio] 2023 Feb 28; Vol. 14 (1), pp. e0356022. <i>Date of Electronic Publication: </i>2023 Feb 06.
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