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Pyrazole Ureas as Low Dose, CNS Penetrant Glucosylceramide Synthase Inhibitors for the Treatment of Parkinson's Disease.

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Title: Pyrazole Ureas as Low Dose, CNS Penetrant Glucosylceramide Synthase Inhibitors for the Treatment of Parkinson's Disease.
Authors: Roecker AJ; Discovery Chemistry, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Schirripa KM; Discovery Chemistry, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Loughran HM; Discovery Chemistry, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Tong L; Discovery Chemistry, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Liang T; Discovery Process Chemistry, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Fillgrove KL; ADME & Discovery Toxicology, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Kuo Y; ADME & Discovery Toxicology, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Bleasby K; ADME Transporters, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Collier H; ADME Transporters, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Altman MD; Computational and Structural Chemistry, Merck & Co., Inc., Boston, Massachusetts 02115, United States., Ford MC; Computational and Structural Chemistry, Merck & Co., Inc., Boston, Massachusetts 02115, United States., Drolet RE; Discovery Biology, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Cosden M; Discovery Biology, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Jinn S; Discovery Biology, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Hatcher NG; Discovery Biology, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Yao L; Discovery Biology, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Kandebo M; Discovery Biology, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Vardigan JD; Discovery Biology, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Flick RB; Discovery Biology, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Liu X; Discovery Biology, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Minnick C; Discovery Biology, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Price LA; Discovery Biology, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Watt ML; Discovery Biology, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Lemaire W; Discovery Biology, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Burlein C; Discovery Biology, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Adam GC; Discovery Biology, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Austin LA; Discovery Pharmaceutical Sciences, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Marcus JN; Discovery Biology, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Smith SM; Discovery Biology, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Fraley ME; Discovery Chemistry, Merck & Co., Inc., West Point, Pennsylvania 19486, United States.
Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2023 Jan 12; Vol. 14 (2), pp. 146-155. Date of Electronic Publication: 2023 Jan 12 (Print Publication: 2023).
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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