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Mitochondrial pyruvate carrier inhibition initiates metabolic crosstalk to stimulate branched chain amino acid catabolism.

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Title: Mitochondrial pyruvate carrier inhibition initiates metabolic crosstalk to stimulate branched chain amino acid catabolism.
Authors: Ferguson D; Department of Medicine, Center for Human Nutrition, Washington University in St. Louis, United States., Eichler SJ; Department of Medicine, Center for Human Nutrition, Washington University in St. Louis, United States., Yiew NKH; Department of Medicine, Center for Human Nutrition, Washington University in St. Louis, United States., Colca JR; Department of Biomedical Sciences, Western Michigan University School of Medicine, Kalamazoo, MI, Cirius Therapeutics, Kalamazoo, MI, United States., Cho K; Department of Chemistry, Washington University in St. Louis, United States; Center for Metabolomics and Isotope Tracing, Washington University in St. Louis, United States., Patti GJ; Department of Medicine, Center for Human Nutrition, Washington University in St. Louis, United States; Department of Chemistry, Washington University in St. Louis, United States; Siteman Cancer Center, Washington University in St. Louis, United States; Center for Metabolomics and Isotope Tracing, Washington University in St. Louis, United States., Shew TM; Department of Medicine, Center for Human Nutrition, Washington University in St. Louis, United States., Lutkewitte AJ; Department of Medicine, Center for Human Nutrition, Washington University in St. Louis, United States., Mukherjee S; Department of Medicine, Center for Human Nutrition, Washington University in St. Louis, United States., McCommis KS; Department of Biochemistry & Molecular Biology, Saint Louis University School of Medicine, United States., Niemi NM; Department of Biochemistry and Molecular Biophysics, Washington University in St. Louis, United States., Finck BN; Department of Medicine, Center for Human Nutrition, Washington University in St. Louis, United States. Electronic address: bfinck@wustl.edu.
Source: Molecular metabolism [Mol Metab] 2023 Apr; Vol. 70, pp. 101694. Date of Electronic Publication: 2023 Feb 18.
Publication Type: Randomized Controlled Trial; Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: Elsevier GmbH Country of Publication: Germany NLM ID: 101605730 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2212-8778 (Electronic) Linking ISSN: 22128778 NLM ISO Abbreviation: Mol Metab Subsets: MEDLINE
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  Data: Mitochondrial pyruvate carrier inhibition initiates metabolic crosstalk to stimulate branched chain amino acid catabolism.
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  Data: <searchLink fieldCode="AU" term="%22Ferguson+D%22">Ferguson D</searchLink>; Department of Medicine, Center for Human Nutrition, Washington University in St. Louis, United States.<br /><searchLink fieldCode="AU" term="%22Eichler+SJ%22">Eichler SJ</searchLink>; Department of Medicine, Center for Human Nutrition, Washington University in St. Louis, United States.<br /><searchLink fieldCode="AU" term="%22Yiew+NKH%22">Yiew NKH</searchLink>; Department of Medicine, Center for Human Nutrition, Washington University in St. Louis, United States.<br /><searchLink fieldCode="AU" term="%22Colca+JR%22">Colca JR</searchLink>; Department of Biomedical Sciences, Western Michigan University School of Medicine, Kalamazoo, MI, Cirius Therapeutics, Kalamazoo, MI, United States.<br /><searchLink fieldCode="AU" term="%22Cho+K%22">Cho K</searchLink>; Department of Chemistry, Washington University in St. Louis, United States; Center for Metabolomics and Isotope Tracing, Washington University in St. Louis, United States.<br /><searchLink fieldCode="AU" term="%22Patti+GJ%22">Patti GJ</searchLink>; Department of Medicine, Center for Human Nutrition, Washington University in St. Louis, United States; Department of Chemistry, Washington University in St. Louis, United States; Siteman Cancer Center, Washington University in St. Louis, United States; Center for Metabolomics and Isotope Tracing, Washington University in St. Louis, United States.<br /><searchLink fieldCode="AU" term="%22Shew+TM%22">Shew TM</searchLink>; Department of Medicine, Center for Human Nutrition, Washington University in St. Louis, United States.<br /><searchLink fieldCode="AU" term="%22Lutkewitte+AJ%22">Lutkewitte AJ</searchLink>; Department of Medicine, Center for Human Nutrition, Washington University in St. Louis, United States.<br /><searchLink fieldCode="AU" term="%22Mukherjee+S%22">Mukherjee S</searchLink>; Department of Medicine, Center for Human Nutrition, Washington University in St. Louis, United States.<br /><searchLink fieldCode="AU" term="%22McCommis+KS%22">McCommis KS</searchLink>; Department of Biochemistry & Molecular Biology, Saint Louis University School of Medicine, United States.<br /><searchLink fieldCode="AU" term="%22Niemi+NM%22">Niemi NM</searchLink>; Department of Biochemistry and Molecular Biophysics, Washington University in St. Louis, United States.<br /><searchLink fieldCode="AU" term="%22Finck+BN%22">Finck BN</searchLink>; Department of Medicine, Center for Human Nutrition, Washington University in St. Louis, United States. Electronic address: bfinck@wustl.edu.
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  Data: <searchLink fieldCode="JN" term="%22101605730%22">Molecular metabolism</searchLink> [Mol Metab] 2023 Apr; Vol. 70, pp. 101694. <i>Date of Electronic Publication: </i>2023 Feb 18.
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