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Rescue of neuropsychiatric phenotypes in a mouse model of 16p11.2 duplication syndrome by genetic correction of an epilepsy network hub.

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Title: Rescue of neuropsychiatric phenotypes in a mouse model of 16p11.2 duplication syndrome by genetic correction of an epilepsy network hub.
Authors: Forrest MP; Department of Neuroscience, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.; Center for Autism and Neurodevelopment, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA., Dos Santos M; Department of Neuroscience, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.; Center for Autism and Neurodevelopment, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA., Piguel NH; Department of Neuroscience, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.; Center for Autism and Neurodevelopment, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA., Wang YZ; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA., Hawkins NA; Department of Pharmacology Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA., Bagchi VA; Department of Neuroscience, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.; Center for Autism and Neurodevelopment, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA., Dionisio LE; Department of Neuroscience, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.; Center for Autism and Neurodevelopment, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA., Yoon S; Department of Neuroscience, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.; Center for Autism and Neurodevelopment, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA., Simkin D; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.; Department of Pharmacology Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA., Martin-de-Saavedra MD; Department of Neuroscience, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.; Center for Autism and Neurodevelopment, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.; Instituto Universitario de Investigación en Neuroquímica, Departamento de Bioquímica y Biología Molecular, Facultad de Farmacia, Universidad Complutense, 28040, Madrid, Spain., Gao R; Department of Neuroscience, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.; Center for Autism and Neurodevelopment, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA., Horan KE; Department of Neuroscience, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.; Center for Autism and Neurodevelopment, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA., George AL Jr; Center for Autism and Neurodevelopment, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.; Department of Pharmacology Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA., LeDoux MS; Department of Psychology, University of Memphis, Memphis, TN, 38152, USA.; Veracity Neuroscience LLC, Memphis, TN, 38157, USA., Kearney JA; Center for Autism and Neurodevelopment, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.; Department of Pharmacology Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA., Savas JN; Center for Autism and Neurodevelopment, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA., Penzes P; Department of Neuroscience, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA. p-penzes@northwestern.edu.; Center for Autism and Neurodevelopment, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA. p-penzes@northwestern.edu.
Source: Nature communications [Nat Commun] 2023 Feb 17; Vol. 14 (1), pp. 825. Date of Electronic Publication: 2023 Feb 17.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Rescue of neuropsychiatric phenotypes in a mouse model of 16p11.2 duplication syndrome by genetic correction of an epilepsy network hub.
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  Data: <searchLink fieldCode="AU" term="%22Forrest+MP%22">Forrest MP</searchLink>; Department of Neuroscience, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.; Center for Autism and Neurodevelopment, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.<br /><searchLink fieldCode="AU" term="%22Dos+Santos+M%22">Dos Santos M</searchLink>; Department of Neuroscience, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.; Center for Autism and Neurodevelopment, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.<br /><searchLink fieldCode="AU" term="%22Piguel+NH%22">Piguel NH</searchLink>; Department of Neuroscience, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.; Center for Autism and Neurodevelopment, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.<br /><searchLink fieldCode="AU" term="%22Wang+YZ%22">Wang YZ</searchLink>; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.<br /><searchLink fieldCode="AU" term="%22Hawkins+NA%22">Hawkins NA</searchLink>; Department of Pharmacology Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.<br /><searchLink fieldCode="AU" term="%22Bagchi+VA%22">Bagchi VA</searchLink>; Department of Neuroscience, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.; Center for Autism and Neurodevelopment, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.<br /><searchLink fieldCode="AU" term="%22Dionisio+LE%22">Dionisio LE</searchLink>; Department of Neuroscience, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.; Center for Autism and Neurodevelopment, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.<br /><searchLink fieldCode="AU" term="%22Yoon+S%22">Yoon S</searchLink>; Department of Neuroscience, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.; Center for Autism and Neurodevelopment, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.<br /><searchLink fieldCode="AU" term="%22Simkin+D%22">Simkin D</searchLink>; 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