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Inhibition of the mitochondrial pyruvate carrier simultaneously mitigates hyperinflammation and hyperglycemia in COVID-19.

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Title: Inhibition of the mitochondrial pyruvate carrier simultaneously mitigates hyperinflammation and hyperglycemia in COVID-19.
Authors: Zhu B; Carter Immunology Center, University of Virginia, Charlottesville, VA 22908, USA.; Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA.; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA., Wei X; Carter Immunology Center, University of Virginia, Charlottesville, VA 22908, USA.; Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA.; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA., Narasimhan H; Carter Immunology Center, University of Virginia, Charlottesville, VA 22908, USA.; Department of Microbiology, Immunology and Cancer Biology, University of Virginia, Charlottesville, VA 22908, USA., Qian W; Carter Immunology Center, University of Virginia, Charlottesville, VA 22908, USA.; Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA., Zhang R; Carter Immunology Center, University of Virginia, Charlottesville, VA 22908, USA.; Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA.; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA., Cheon IS; Carter Immunology Center, University of Virginia, Charlottesville, VA 22908, USA.; Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA.; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA., Wu Y; Carter Immunology Center, University of Virginia, Charlottesville, VA 22908, USA.; Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA.; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA., Li C; Carter Immunology Center, University of Virginia, Charlottesville, VA 22908, USA.; Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA.; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA., Jones RG; Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI 49503, USA., Kaplan MH; Department of Microbiology and Immunology, Indiana University of School of Medicine, Indianapolis, IN 46202, USA., Vassallo RA; Department of Microbiology, Immunology and Cancer Biology, University of Virginia, Charlottesville, VA 22908, USA., Braciale TJ; Carter Immunology Center, University of Virginia, Charlottesville, VA 22908, USA.; Department of Pathology, University of Virginia, Charlottesville, VA 22908, USA., Somerville L; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA., Colca JR; Cirius Therapeutics, Kalamazoo, MI 49007, USA., Pandey A; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA.; Manipal Academy of Higher Education, Manipal-576 104, Karnataka, India., Jackson PEH; Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA., Mann BJ; Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA.; Department of Microbiology, Immunology and Cancer Biology, University of Virginia, Charlottesville, VA 22908, USA., Krawczyk CM; Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI 49503, USA., Sturek JM; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA., Sun J; Carter Immunology Center, University of Virginia, Charlottesville, VA 22908, USA.; Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA.; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.; Department of Microbiology, Immunology and Cancer Biology, University of Virginia, Charlottesville, VA 22908, USA.
Source: Science immunology [Sci Immunol] 2023 Apr 14; Vol. 8 (82), pp. eadf0348. Date of Electronic Publication: 2023 Apr 14.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101688624 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2470-9468 (Electronic) Linking ISSN: 24709468 NLM ISO Abbreviation: Sci Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Inhibition of the mitochondrial pyruvate carrier simultaneously mitigates hyperinflammation and hyperglycemia in COVID-19.
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  Data: <searchLink fieldCode="AU" term="%22Zhu+B%22">Zhu B</searchLink>; Carter Immunology Center, University of Virginia, Charlottesville, VA 22908, USA.; Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA.; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.<br /><searchLink fieldCode="AU" term="%22Wei+X%22">Wei X</searchLink>; Carter Immunology Center, University of Virginia, Charlottesville, VA 22908, USA.; Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA.; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.<br /><searchLink fieldCode="AU" term="%22Narasimhan+H%22">Narasimhan H</searchLink>; Carter Immunology Center, University of Virginia, Charlottesville, VA 22908, USA.; Department of Microbiology, Immunology and Cancer Biology, University of Virginia, Charlottesville, VA 22908, USA.<br /><searchLink fieldCode="AU" term="%22Qian+W%22">Qian W</searchLink>; Carter Immunology Center, University of Virginia, Charlottesville, VA 22908, USA.; Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+R%22">Zhang R</searchLink>; Carter Immunology Center, University of Virginia, Charlottesville, VA 22908, USA.; Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA.; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.<br /><searchLink fieldCode="AU" term="%22Cheon+IS%22">Cheon IS</searchLink>; Carter Immunology Center, University of Virginia, Charlottesville, VA 22908, USA.; Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA.; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.<br /><searchLink fieldCode="AU" term="%22Wu+Y%22">Wu Y</searchLink>; Carter Immunology Center, University of Virginia, Charlottesville, VA 22908, USA.; Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA.; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.<br /><searchLink fieldCode="AU" term="%22Li+C%22">Li C</searchLink>; Carter Immunology Center, University of Virginia, Charlottesville, VA 22908, USA.; Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA.; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.<br /><searchLink fieldCode="AU" term="%22Jones+RG%22">Jones RG</searchLink>; Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI 49503, USA.<br /><searchLink fieldCode="AU" term="%22Kaplan+MH%22">Kaplan MH</searchLink>; Department of Microbiology and Immunology, Indiana University of School of Medicine, Indianapolis, IN 46202, USA.<br /><searchLink fieldCode="AU" term="%22Vassallo+RA%22">Vassallo RA</searchLink>; Department of Microbiology, Immunology and Cancer Biology, University of Virginia, Charlottesville, VA 22908, USA.<br /><searchLink fieldCode="AU" term="%22Braciale+TJ%22">Braciale TJ</searchLink>; Carter Immunology Center, University of Virginia, Charlottesville, VA 22908, USA.; Department of Pathology, University of Virginia, Charlottesville, VA 22908, USA.<br /><searchLink fieldCode="AU" term="%22Somerville+L%22">Somerville L</searchLink>; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA.<br /><searchLink fieldCode="AU" term="%22Colca+JR%22">Colca JR</searchLink>; Cirius Therapeutics, Kalamazoo, MI 49007, USA.<br /><searchLink fieldCode="AU" term="%22Pandey+A%22">Pandey A</searchLink>; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA.; Manipal Academy of Higher Education, Manipal-576 104, Karnataka, India.<br /><searchLink fieldCode="AU" term="%22Jackson+PEH%22">Jackson PEH</searchLink>; Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA.<br /><searchLink fieldCode="AU" term="%22Mann+BJ%22">Mann BJ</searchLink>; Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA.; Department of Microbiology, Immunology and Cancer Biology, University of Virginia, Charlottesville, VA 22908, USA.<br /><searchLink fieldCode="AU" term="%22Krawczyk+CM%22">Krawczyk CM</searchLink>; Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI 49503, USA.<br /><searchLink fieldCode="AU" term="%22Sturek+JM%22">Sturek JM</searchLink>; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA.<br /><searchLink fieldCode="AU" term="%22Sun+J%22">Sun J</searchLink>; Carter Immunology Center, University of Virginia, Charlottesville, VA 22908, USA.; Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA.; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.; Department of Microbiology, Immunology and Cancer Biology, University of Virginia, Charlottesville, VA 22908, USA.
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  Data: <searchLink fieldCode="JN" term="%22101688624%22">Science immunology</searchLink> [Sci Immunol] 2023 Apr 14; Vol. 8 (82), pp. eadf0348. <i>Date of Electronic Publication: </i>2023 Apr 14.
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