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Synthesis of New Shogaol Analogues as NRF2 Activators and Evaluation of Their Anti-Inflammatory Activity, Modes of Action and Metabolic Stability.

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Title: Synthesis of New Shogaol Analogues as NRF2 Activators and Evaluation of Their Anti-Inflammatory Activity, Modes of Action and Metabolic Stability.
Authors: Mak KK; Department of Pharmaceutical Chemistry, School of Pharmacy, International Medical University, 126, Jalan Jalil Perkasa 19, Bukit Jalil, Kuala Lumpur 57000, Selangor, Malaysia.; Centre of Excellence for Bioactive Molecules and Drug Delivery, Institute for Research, Development & Innovation, International Medical University, 126, Jalan Jalil Perkasa 19, Bukit Jalil, Kuala Lumpur 57000, Selangor, Malaysia.; School of Postgraduate Studies, International Medical University, 126, Jalan Jalil Perkasa 19, Bukit Jalil, Kuala Lumpur 57000, Selangor, Malaysia., Shiming Z; School of Postgraduate Studies, International Medical University, 126, Jalan Jalil Perkasa 19, Bukit Jalil, Kuala Lumpur 57000, Selangor, Malaysia., Sakirolla R; Department of Chemistry, Central University of Karnataka, Gulbarga 585367, Karnataka, India., Balijepalli MK; Department of Pharmacology, Faculty of Medicine, Bioscience & Nursing, MAHSA University, Jln SP 2, Bandar Saujana Putra, Jenjarom 42610, Selangor, Malaysia., Dinkova-Kostova AT; Division of Cellular Medicine, School of Medicine, Jacqui Wood Cancer Centre, University of Dundee, Dundee DD1 4HN, UK.; Departments of Medicine and Pharmacology and Molecular Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA., Epemolu O; Principal Research Scientist-In Vitro/In Vivo DMPK, Charles River Laboratories Edinburgh Ltd., Tranent EH33 2NE, UK., Mohd Z; Department of Pharmaceutical Chemistry, School of Pharmacy, International Medical University, 126, Jalan Jalil Perkasa 19, Bukit Jalil, Kuala Lumpur 57000, Selangor, Malaysia.; Centre of Excellence for Bioactive Molecules and Drug Delivery, Institute for Research, Development & Innovation, International Medical University, 126, Jalan Jalil Perkasa 19, Bukit Jalil, Kuala Lumpur 57000, Selangor, Malaysia., Pichika MR; Department of Pharmaceutical Chemistry, School of Pharmacy, International Medical University, 126, Jalan Jalil Perkasa 19, Bukit Jalil, Kuala Lumpur 57000, Selangor, Malaysia.; Centre of Excellence for Bioactive Molecules and Drug Delivery, Institute for Research, Development & Innovation, International Medical University, 126, Jalan Jalil Perkasa 19, Bukit Jalil, Kuala Lumpur 57000, Selangor, Malaysia.
Source: Antioxidants (Basel, Switzerland) [Antioxidants (Basel)] 2023 Feb 13; Vol. 12 (2). Date of Electronic Publication: 2023 Feb 13.
Publication Type: Journal Article
Journal Info: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101668981 Publication Model: Electronic Cited Medium: Print ISSN: 2076-3921 (Print) Linking ISSN: 20763921 NLM ISO Abbreviation: Antioxidants (Basel) Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Synthesis of New Shogaol Analogues as NRF2 Activators and Evaluation of Their Anti-Inflammatory Activity, Modes of Action and Metabolic Stability.
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  Data: <searchLink fieldCode="AU" term="%22Mak+KK%22">Mak KK</searchLink>; Department of Pharmaceutical Chemistry, School of Pharmacy, International Medical University, 126, Jalan Jalil Perkasa 19, Bukit Jalil, Kuala Lumpur 57000, Selangor, Malaysia.; Centre of Excellence for Bioactive Molecules and Drug Delivery, Institute for Research, Development & Innovation, International Medical University, 126, Jalan Jalil Perkasa 19, Bukit Jalil, Kuala Lumpur 57000, Selangor, Malaysia.; School of Postgraduate Studies, International Medical University, 126, Jalan Jalil Perkasa 19, Bukit Jalil, Kuala Lumpur 57000, Selangor, Malaysia.<br /><searchLink fieldCode="AU" term="%22Shiming+Z%22">Shiming Z</searchLink>; School of Postgraduate Studies, International Medical University, 126, Jalan Jalil Perkasa 19, Bukit Jalil, Kuala Lumpur 57000, Selangor, Malaysia.<br /><searchLink fieldCode="AU" term="%22Sakirolla+R%22">Sakirolla R</searchLink>; Department of Chemistry, Central University of Karnataka, Gulbarga 585367, Karnataka, India.<br /><searchLink fieldCode="AU" term="%22Balijepalli+MK%22">Balijepalli MK</searchLink>; Department of Pharmacology, Faculty of Medicine, Bioscience & Nursing, MAHSA University, Jln SP 2, Bandar Saujana Putra, Jenjarom 42610, Selangor, Malaysia.<br /><searchLink fieldCode="AU" term="%22Dinkova-Kostova+AT%22">Dinkova-Kostova AT</searchLink>; Division of Cellular Medicine, School of Medicine, Jacqui Wood Cancer Centre, University of Dundee, Dundee DD1 4HN, UK.; Departments of Medicine and Pharmacology and Molecular Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.<br /><searchLink fieldCode="AU" term="%22Epemolu+O%22">Epemolu O</searchLink>; Principal Research Scientist-In Vitro/In Vivo DMPK, Charles River Laboratories Edinburgh Ltd., Tranent EH33 2NE, UK.<br /><searchLink fieldCode="AU" term="%22Mohd+Z%22">Mohd Z</searchLink>; Department of Pharmaceutical Chemistry, School of Pharmacy, International Medical University, 126, Jalan Jalil Perkasa 19, Bukit Jalil, Kuala Lumpur 57000, Selangor, Malaysia.; Centre of Excellence for Bioactive Molecules and Drug Delivery, Institute for Research, Development & Innovation, International Medical University, 126, Jalan Jalil Perkasa 19, Bukit Jalil, Kuala Lumpur 57000, Selangor, Malaysia.<br /><searchLink fieldCode="AU" term="%22Pichika+MR%22">Pichika MR</searchLink>; Department of Pharmaceutical Chemistry, School of Pharmacy, International Medical University, 126, Jalan Jalil Perkasa 19, Bukit Jalil, Kuala Lumpur 57000, Selangor, Malaysia.; Centre of Excellence for Bioactive Molecules and Drug Delivery, Institute for Research, Development & Innovation, International Medical University, 126, Jalan Jalil Perkasa 19, Bukit Jalil, Kuala Lumpur 57000, Selangor, Malaysia.
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  Data: <searchLink fieldCode="JN" term="%22101668981%22">Antioxidants (Basel, Switzerland)</searchLink> [Antioxidants (Basel)] 2023 Feb 13; Vol. 12 (2). <i>Date of Electronic Publication: </i>2023 Feb 13.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22MDPI+AG%22">MDPI AG </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101668981 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Print <i>ISSN: </i>2076-3921 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220763921%22">20763921 </searchLink><i>NLM ISO Abbreviation: </i>Antioxidants (Basel) <i>Subsets: </i>PubMed not MEDLINE
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              Text: 2023 Feb 13
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