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Systematic Investigation of Tether Length and Phosphorus Configuration in Backbone Constrained Macrocyclic Nucleic Acids to Modulate Binding Kinetics for RNA.

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Title: Systematic Investigation of Tether Length and Phosphorus Configuration in Backbone Constrained Macrocyclic Nucleic Acids to Modulate Binding Kinetics for RNA.
Authors: Rajasekaran T; Department of Chemistry, Université de Montréal, Quebec H3C 3J7, Canada., Freestone GC; Department of Medicinal Chemistry, Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, California 92010, United States., Galindo-Murillo R; Department of Medicinal Chemistry, Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, California 92010, United States., Lugato B; Department of Chemistry, Université de Montréal, Quebec H3C 3J7, Canada., Gaus H; Department of Medicinal Chemistry, Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, California 92010, United States., Migawa MT; Department of Medicinal Chemistry, Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, California 92010, United States., Swayze EE; Department of Medicinal Chemistry, Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, California 92010, United States., Cheatham TE 3rd; Department of Medicinal Chemistry, College of Pharmacy, University of Utah, 2000 East 30 South Skaggs 201, Salt Lake City, Utah 84112, United States., Seth PP; Department of Medicinal Chemistry, Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, California 92010, United States., Hanessian S; Department of Chemistry, Université de Montréal, Quebec H3C 3J7, Canada.; Department of Pharmaceutical Sciences, University of California, Irvine, California 92697, United States.
Source: The Journal of organic chemistry [J Org Chem] 2023 Mar 17; Vol. 88 (6), pp. 3599-3614. Date of Electronic Publication: 2023 Mar 01.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 2985193R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6904 (Electronic) Linking ISSN: 00223263 NLM ISO Abbreviation: J Org Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Systematic Investigation of Tether Length and Phosphorus Configuration in Backbone Constrained Macrocyclic Nucleic Acids to Modulate Binding Kinetics for RNA.
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        Value: 10.1021/acs.joc.2c02796
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              Text: 2023 Mar 17
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