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Human germline heterozygous gain-of-function STAT6 variants cause severe allergic disease.

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Title: Human germline heterozygous gain-of-function STAT6 variants cause severe allergic disease.
Authors: Sharma M; Dept. of Pediatrics, BC Children's Hospital, University of British Columbia , Vancouver, Canada., Leung D; Dept. of Paediatrics and Adolescent Medicine, School of Clinical Medicine, The University of Hong Kong , Hong Kong, China., Momenilandi M; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, Necker Hospital for Sick Children, Paris, France.; Imagine Institute, University of Paris-Cité, Paris, France., Jones LCW; Dept. of Pediatrics, BC Children's Hospital, University of British Columbia , Vancouver, Canada., Pacillo L; Dept. of System Medicine, Pediatric Chair, University of Tor Vergata, Rome, Italy.; Academic Dept. of Pediatrics (DPUO), Unit of Clinical Immunology and Vaccinology, IRCCS Bambin Gesù Children Hospital, Rome, Italy.; Research Unit of Primary Immunodeficiency, IRCCS Bambin Gesù Children Hospital, Rome, Italy., James AE; Translational Allergic Immunopathology Unit, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH) , Bethesda, MD, USA., Murrell JR; Pathology and Laboratory Medicine, Division of Genomic Diagnostics, Children's Hospital of Philadelphia , Philadelphia, PA, USA., Delafontaine S; Dept. of Microbiology, Immunology and Transplantation, Laboratory for Inborn Errors of Immunity, KU Leuven , Leuven, Belgium.; Dept. of Pediatrics, Pediatric Immunodeficiencies Division, University Hospitals Leuven , Leuven, Belgium., Maimaris J; Institute of Immunity and Transplantation, Division of Infection and Immunity, University College London , London, UK.; Dept. of Immunology, Royal Free London NHS Foundation Trust , London, UK., Vaseghi-Shanjani M; Dept. of Pediatrics, BC Children's Hospital, University of British Columbia , Vancouver, Canada., Del Bel KL; Dept. of Pediatrics, BC Children's Hospital, University of British Columbia , Vancouver, Canada., Lu HY; Division of Hematology/Oncology, Boston Children's Hospital , Harvard Medical School, Boston, MA, USA.; Dept. of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School , Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard , Cambridge, MA, USA., Chua GT; Dept. of Paediatrics and Adolescent Medicine, School of Clinical Medicine, The University of Hong Kong , Hong Kong, China.; Allergy Centre, Union Hospital , Hong Kong, China., Di Cesare S; Dept. of System Medicine, Pediatric Chair, University of Tor Vergata, Rome, Italy.; Research Unit of Primary Immunodeficiency, IRCCS Bambin Gesù Children Hospital, Rome, Italy., Fornes O; Centre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute , Vancouver, Canada.; Dept. of Medical Genetics, University of British Columbia , Vancouver, Canada., Liu Z; Dept. of Paediatrics and Adolescent Medicine, School of Clinical Medicine, The University of Hong Kong , Hong Kong, China., Di Matteo G; Academic Dept. of Pediatrics (DPUO), Unit of Clinical Immunology and Vaccinology, IRCCS Bambin Gesù Children Hospital, Rome, Italy.; Research Unit of Primary Immunodeficiency, IRCCS Bambin Gesù Children Hospital, Rome, Italy., Fu MP; Dept. of Medical Genetics, The University of British Columbia , Vancouver, Canada.; Genome Science and Technology Program, Faculty of Science, The University of British Columbia , Vancouver, Canada., Amodio D; Academic Dept. of Pediatrics (DPUO), Unit of Clinical Immunology and Vaccinology, IRCCS Bambin Gesù Children Hospital, Rome, Italy., Tam IYS; Dept. of Paediatrics and Adolescent Medicine, School of Clinical Medicine, The University of Hong Kong , Hong Kong, China., Chan GSW; Dept. of Pathology, Queen Mary Hospital , Hong Kong, China., Sharma AA; Dept. of Pathology, Emory University , Atlanta, GA, USA., Dalmann J; Dept. of Pediatrics, BC Children's Hospital, University of British Columbia , Vancouver, Canada., van der Lee R; Centre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute , Vancouver, Canada.; Dept. of Medical Genetics, University of British Columbia , Vancouver, Canada., Blanchard-Rohner G; Dept. of Pediatrics, BC Children's Hospital, University of British Columbia , Vancouver, Canada.; Unit of Immunology and Vaccinology, Division of General Pediatrics, Dept. of Woman, Child, and Adolescent Medicine, Geneva University Hospitals and Faculty of Medicine, University of Geneva , Geneva, Switzerland., Lin S; Dept. of Pediatrics, BC Children's Hospital, University of British Columbia , Vancouver, Canada., Philippot Q; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, Necker Hospital for Sick Children, Paris, France.; Imagine Institute, University of Paris-Cité, Paris, France., Richmond PA; Dept. of Pediatrics, BC Children's Hospital, University of British Columbia , Vancouver, Canada.; Centre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute , Vancouver, Canada., Lee JJ; Centre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute , Vancouver, Canada.; Genome Science and Technology Graduate Program, University of British Columbia , Vancouver, Canada., Matthews A; Centre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute , Vancouver, Canada.; Dept. of Paediatrics, University of Toronto , Toronto, Canada., Seear M; Dept. of Pediatrics, BC Children's Hospital, University of British Columbia , Vancouver, Canada., Turvey AK; Dept. of Pediatrics, BC Children's Hospital, University of British Columbia , Vancouver, Canada., Philips RL; Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, NIH , Bethesda, MD, USA., Brown-Whitehorn TF; Dept. of Pediatrics, Division of Allergy and Immunology, Children's Hospital of Philadelphia , Philadelphia, PA, USA., Gray CJ; Pediatrics, Division of Human Genetics, Children's Hospital of Philadelphia , Philadelphia, PA, USA., Izumi K; Pediatrics, Division of Human Genetics, Children's Hospital of Philadelphia , Philadelphia, PA, USA., Treat JR; Pediatrics, Division of Pediatric Dermatology, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA, USA., Wood KH; Pathology and Laboratory Medicine, Division of Genomic Diagnostics, Children's Hospital of Philadelphia , Philadelphia, PA, USA., Lack J; NIAID Collaborative Bioinformatics Resource, NIAID , NIH, Bethesda, MD, USA., Khleborodova A; NIAID Collaborative Bioinformatics Resource, NIAID , NIH, Bethesda, MD, USA., Niemela JE; Immunology Service, Clinical Center, NIH , Bethesda, MD, USA., Yang X; Dept. of Paediatrics and Adolescent Medicine, School of Clinical Medicine, The University of Hong Kong , Hong Kong, China., Liang R; Dept. of Paediatrics and Adolescent Medicine, School of Clinical Medicine, The University of Hong Kong , Hong Kong, China., Kui L; Dept. of Paediatrics and Adolescent Medicine, School of Clinical Medicine, The University of Hong Kong , Hong Kong, China.; Dept. of Pediatrics, University of California San Diego , La Jolla, CA, USA., Wong CSM; Dept. of Medicine, Divison of Dermatology, The University of Hong Kong , Hong Kong, China., Poon GWK; Dept. of Paediatrics and Adolescent Medicine, Queen Mary Hospital , Hong Kong, China., Hoischen A; Dept. of Human Genetics, Radboud University Medical Center , Nijmegen, Netherlands., van der Made CI; Dept. of Human Genetics, Radboud University Medical Center , Nijmegen, Netherlands., Yang J; Dept. of Paediatrics and Adolescent Medicine, School of Clinical Medicine, The University of Hong Kong , Hong Kong, China., Chan KW; Dept. of Paediatrics and Adolescent Medicine, School of Clinical Medicine, The University of Hong Kong , Hong Kong, China., Rosa Duque JSD; Dept. of Paediatrics and Adolescent Medicine, School of Clinical Medicine, The University of Hong Kong , Hong Kong, China., Lee PPW; Dept. of Paediatrics and Adolescent Medicine, School of Clinical Medicine, The University of Hong Kong , Hong Kong, China., Ho MHK; Dept. of Paediatrics and Adolescent Medicine, School of Clinical Medicine, The University of Hong Kong , Hong Kong, China.; Virtus Medical , Hong Kong, China., Chung BHY; Dept. of Paediatrics and Adolescent Medicine, School of Clinical Medicine, The University of Hong Kong , Hong Kong, China., Le HTM; Pediatric Center, Vinmec Times City International General Hospital , Hanoi, Vietnam., Yang W; Dept. of Paediatrics and Adolescent Medicine, School of Clinical Medicine, The University of Hong Kong , Hong Kong, China., Rohani P; Pediatrics, Pediatric Gastroenterology and Hepatology Research Center, Pediatrics Centre of Excellence, Children's Medical Center, University of Medical Sciences , Tehran, Iran., Fouladvand A; Pediatrics, Allergy and Clinical Immunology, Lorestan University of Medical Sciences , Khoramabad, Iran., Rokni-Zadeh H; Dept. of Medical Biotechnology, School of Medicine, Zanjan University of Medical Sciences , Zanjan, Iran., Changi-Ashtiani M; School of Mathematics, Institute for Research in Fundamental Sciences , Tehran, Iran., Miryounesi M; Dept. of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences , Tehran, Iran., Puel A; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, Necker Hospital for Sick Children, Paris, France.; Imagine Institute, University of Paris-Cité, Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA., Shahrooei M; Microbiology and Immunology, Laboratory of Clinical Bacteriology and Mycology, KU Leuven , Leuven, Belgium., Finocchi A; Dept. of System Medicine, Pediatric Chair, University of Tor Vergata, Rome, Italy.; Research Unit of Primary Immunodeficiency, IRCCS Bambin Gesù Children Hospital, Rome, Italy., Rossi P; Dept. of System Medicine, Pediatric Chair, University of Tor Vergata, Rome, Italy.; DPUO, Research Unit of Infectivology and Pediatrics Drugs Development, Bambino Gesù Children Hospital IRCCS , Rome, Italy., Rivalta B; Dept. of System Medicine, Pediatric Chair, University of Tor Vergata, Rome, Italy.; Academic Dept. of Pediatrics (DPUO), Unit of Clinical Immunology and Vaccinology, IRCCS Bambin Gesù Children Hospital, Rome, Italy.; Research Unit of Primary Immunodeficiency, IRCCS Bambin Gesù Children Hospital, Rome, Italy., Cifaldi C; Research Unit of Primary Immunodeficiency, IRCCS Bambin Gesù Children Hospital, Rome, Italy., Novelli A; Laboratory of Medical Genetics, Translational Cytogenomics Research Unit, Bambino Gesù Children Hospital IRCCS , Rome, Italy., Passarelli C; Laboratory of Medical Genetics, Translational Cytogenomics Research Unit, Bambino Gesù Children Hospital IRCCS , Rome, Italy., Arasi S; Allergy Unit, Area of Translational Research in Pediatric Specialities, Bambino Gesù Children's Hospital, IRCCS , Rome, Italy., Bullens D; Dept. of Microbiology, Immunology and Transplantation, Allergy and Clinical Immunology Research Group, KU Leuven , Leuven, Belgium.; Dept. of Pediatrics, Pediatric Allergy Division, University Hospitals Leuven , Leuven, Belgium., Sauer K; Dept. of Pediatrics, Pediatric Pulmonology Division, AZ Sint-Jan Brugge , Brugge, Belgium.; Dept. of Pediatrics, Pediatric Pulmonology Division, University Hospitals Leuven , Leuven, Belgium., Claeys T; Dept. of Pediatrics, Pediatric Gastroenterology Division, AZ Sint-Jan Brugge , Brugge, Belgium., Biggs CM; Dept. of Pediatrics, BC Children's Hospital, University of British Columbia , Vancouver, Canada., Morris EC; Institute of Immunity and Transplantation, Division of Infection and Immunity, University College London , London, UK.; Dept. of Immunology, Royal Free London NHS Foundation Trust , London, UK., Rosenzweig SD; Immunology Service, Clinical Center, NIH , Bethesda, MD, USA., O'Shea JJ; Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, NIH , Bethesda, MD, USA., Wasserman WW; Centre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute , Vancouver, Canada., Bedford HM; Dept. of Paediatrics, University of Toronto , Toronto, Canada.; Genetics Program, North York General Hospital , Toronto, Canada., van Karnebeek CDM; Centre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute , Vancouver, Canada.; Depts. of Pediatrics and Clinical Genetics, Amsterdam University Medical Centers , Amsterdam, Netherlands., Palma P; Dept. of System Medicine, Pediatric Chair, University of Tor Vergata, Rome, Italy.; Academic Dept. of Pediatrics (DPUO), Unit of Clinical Immunology and Vaccinology, IRCCS Bambin Gesù Children Hospital, Rome, Italy., Burns SO; Institute of Immunity and Transplantation, Division of Infection and Immunity, University College London , London, UK.; Dept. of Immunology, Royal Free London NHS Foundation Trust , London, UK., Meyts I; Dept. of Microbiology, Immunology and Transplantation, Laboratory for Inborn Errors of Immunity, KU Leuven , Leuven, Belgium.; Dept. of Pediatrics, Pediatric Immunodeficiencies Division, University Hospitals Leuven , Leuven, Belgium., Casanova JL; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, Necker Hospital for Sick Children, Paris, France.; Imagine Institute, University of Paris-Cité, Paris, France.; Howard Hughes Medical Institute, The Rockefeller University, New York, NY, USA.; Department of Pediatrics, Necker Hospital for Sick Children, AP-HP, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA., Lyons JJ; Translational Allergic Immunopathology Unit, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH) , Bethesda, MD, USA., Parvaneh N; Department of Pediatrics, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran., Nguyen ATV; Dept. of Immunology, Allergy and Rheumatology, Division of Primary Immunodeficiency, Vietnam National Children's Hospital , Hanoi, Vietnam., Cancrini C; Dept. of System Medicine, Pediatric Chair, University of Tor Vergata, Rome, Italy.; Research Unit of Primary Immunodeficiency, IRCCS Bambin Gesù Children Hospital, Rome, Italy., Heimall J; Dept. of Pediatrics, Division of Allergy and Immunology, Children's Hospital of Philadelphia , Philadelphia, PA, USA., Ahmed H; Faculty of Health Sciences, McMaster University , Hamilton, Canada., McKinnon ML; Dept. of Medical Genetics, University of British Columbia , Vancouver, Canada., Lau YL; Dept. of Paediatrics and Adolescent Medicine, School of Clinical Medicine, The University of Hong Kong , Hong Kong, China., Béziat V; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, Necker Hospital for Sick Children, Paris, France.; Imagine Institute, University of Paris-Cité, Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA., Turvey SE; Dept. of Pediatrics, BC Children's Hospital, University of British Columbia , Vancouver, Canada.
Source: The Journal of experimental medicine [J Exp Med] 2023 May 01; Vol. 220 (5). Date of Electronic Publication: 2023 Mar 08.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Intramural
Journal Info: Publisher: Rockefeller University Press Country of Publication: United States NLM ID: 2985109R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1540-9538 (Electronic) Linking ISSN: 00221007 NLM ISO Abbreviation: J Exp Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 36884218
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
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Items – Name: Title
  Label: Title
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  Data: Human germline heterozygous gain-of-function STAT6 variants cause severe allergic disease.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Sharma+M%22">Sharma M</searchLink>; Dept. of Pediatrics, BC Children's Hospital, University of British Columbia , Vancouver, Canada.<br /><searchLink fieldCode="AU" term="%22Leung+D%22">Leung D</searchLink>; Dept. of Paediatrics and Adolescent Medicine, School of Clinical Medicine, The University of Hong Kong , Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Momenilandi+M%22">Momenilandi M</searchLink>; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, Necker Hospital for Sick Children, Paris, France.; Imagine Institute, University of Paris-Cité, Paris, France.<br /><searchLink fieldCode="AU" term="%22Jones+LCW%22">Jones LCW</searchLink>; Dept. of Pediatrics, BC Children's Hospital, University of British Columbia , Vancouver, Canada.<br /><searchLink fieldCode="AU" term="%22Pacillo+L%22">Pacillo L</searchLink>; Dept. of System Medicine, Pediatric Chair, University of Tor Vergata, Rome, Italy.; Academic Dept. of Pediatrics (DPUO), Unit of Clinical Immunology and Vaccinology, IRCCS Bambin Gesù Children Hospital, Rome, Italy.; Research Unit of Primary Immunodeficiency, IRCCS Bambin Gesù Children Hospital, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22James+AE%22">James AE</searchLink>; Translational Allergic Immunopathology Unit, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH) , Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Murrell+JR%22">Murrell JR</searchLink>; Pathology and Laboratory Medicine, Division of Genomic Diagnostics, Children's Hospital of Philadelphia , Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Delafontaine+S%22">Delafontaine S</searchLink>; Dept. of Microbiology, Immunology and Transplantation, Laboratory for Inborn Errors of Immunity, KU Leuven , Leuven, Belgium.; Dept. of Pediatrics, Pediatric Immunodeficiencies Division, University Hospitals Leuven , Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Maimaris+J%22">Maimaris J</searchLink>; Institute of Immunity and Transplantation, Division of Infection and Immunity, University College London , London, UK.; Dept. of Immunology, Royal Free London NHS Foundation Trust , London, UK.<br /><searchLink fieldCode="AU" term="%22Vaseghi-Shanjani+M%22">Vaseghi-Shanjani M</searchLink>; Dept. of Pediatrics, BC Children's Hospital, University of British Columbia , Vancouver, Canada.<br /><searchLink fieldCode="AU" term="%22Del+Bel+KL%22">Del Bel KL</searchLink>; Dept. of Pediatrics, BC Children's Hospital, University of British Columbia , Vancouver, Canada.<br /><searchLink fieldCode="AU" term="%22Lu+HY%22">Lu HY</searchLink>; Division of Hematology/Oncology, Boston Children's Hospital , Harvard Medical School, Boston, MA, USA.; Dept. of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School , Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard , Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Chua+GT%22">Chua GT</searchLink>; Dept. of Paediatrics and Adolescent Medicine, School of Clinical Medicine, The University of Hong Kong , Hong Kong, China.; Allergy Centre, Union Hospital , Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Di+Cesare+S%22">Di Cesare S</searchLink>; Dept. of System Medicine, Pediatric Chair, University of Tor Vergata, Rome, Italy.; Research Unit of Primary Immunodeficiency, IRCCS Bambin Gesù Children Hospital, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Fornes+O%22">Fornes O</searchLink>; Centre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute , Vancouver, Canada.; Dept. of Medical Genetics, University of British Columbia , Vancouver, Canada.<br /><searchLink fieldCode="AU" term="%22Liu+Z%22">Liu Z</searchLink>; Dept. of Paediatrics and Adolescent Medicine, School of Clinical Medicine, The University of Hong Kong , Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Di+Matteo+G%22">Di Matteo G</searchLink>; Academic Dept. of Pediatrics (DPUO), Unit of Clinical Immunology and Vaccinology, IRCCS Bambin Gesù Children Hospital, Rome, Italy.; Research Unit of Primary Immunodeficiency, IRCCS Bambin Gesù Children Hospital, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Fu+MP%22">Fu MP</searchLink>; Dept. of Medical Genetics, The University of British Columbia , Vancouver, Canada.; Genome Science and Technology Program, Faculty of Science, The University of British Columbia , Vancouver, Canada.<br /><searchLink fieldCode="AU" term="%22Amodio+D%22">Amodio D</searchLink>; Academic Dept. of Pediatrics (DPUO), Unit of Clinical Immunology and Vaccinology, IRCCS Bambin Gesù Children Hospital, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Tam+IYS%22">Tam IYS</searchLink>; Dept. of Paediatrics and Adolescent Medicine, School of Clinical Medicine, The University of Hong Kong , Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Chan+GSW%22">Chan GSW</searchLink>; Dept. of Pathology, Queen Mary Hospital , Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Sharma+AA%22">Sharma AA</searchLink>; Dept. of Pathology, Emory University , Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Dalmann+J%22">Dalmann J</searchLink>; Dept. of Pediatrics, BC Children's Hospital, University of British Columbia , Vancouver, Canada.<br /><searchLink fieldCode="AU" term="%22van+der+Lee+R%22">van der Lee R</searchLink>; Centre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute , Vancouver, Canada.; Dept. of Medical Genetics, University of British Columbia , Vancouver, Canada.<br /><searchLink fieldCode="AU" term="%22Blanchard-Rohner+G%22">Blanchard-Rohner G</searchLink>; Dept. of Pediatrics, BC Children's Hospital, University of British Columbia , Vancouver, Canada.; Unit of Immunology and Vaccinology, Division of General Pediatrics, Dept. of Woman, Child, and Adolescent Medicine, Geneva University Hospitals and Faculty of Medicine, University of Geneva , Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Lin+S%22">Lin S</searchLink>; Dept. of Pediatrics, BC Children's Hospital, University of British Columbia , Vancouver, Canada.<br /><searchLink fieldCode="AU" term="%22Philippot+Q%22">Philippot Q</searchLink>; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, Necker Hospital for Sick Children, Paris, France.; Imagine Institute, University of Paris-Cité, Paris, France.<br /><searchLink fieldCode="AU" term="%22Richmond+PA%22">Richmond PA</searchLink>; Dept. of Pediatrics, BC Children's Hospital, University of British Columbia , Vancouver, Canada.; Centre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute , Vancouver, Canada.<br /><searchLink fieldCode="AU" term="%22Lee+JJ%22">Lee JJ</searchLink>; Centre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute , Vancouver, Canada.; Genome Science and Technology Graduate Program, University of British Columbia , Vancouver, Canada.<br /><searchLink fieldCode="AU" term="%22Matthews+A%22">Matthews A</searchLink>; Centre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute , Vancouver, Canada.; Dept. of Paediatrics, University of Toronto , Toronto, Canada.<br /><searchLink fieldCode="AU" term="%22Seear+M%22">Seear M</searchLink>; Dept. of Pediatrics, BC Children's Hospital, University of British Columbia , Vancouver, Canada.<br /><searchLink fieldCode="AU" term="%22Turvey+AK%22">Turvey AK</searchLink>; Dept. of Pediatrics, BC Children's Hospital, University of British Columbia , Vancouver, Canada.<br /><searchLink fieldCode="AU" term="%22Philips+RL%22">Philips RL</searchLink>; Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, NIH , Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Brown-Whitehorn+TF%22">Brown-Whitehorn TF</searchLink>; Dept. of Pediatrics, Division of Allergy and Immunology, Children's Hospital of Philadelphia , Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Gray+CJ%22">Gray CJ</searchLink>; Pediatrics, Division of Human Genetics, Children's Hospital of Philadelphia , Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Izumi+K%22">Izumi K</searchLink>; Pediatrics, Division of Human Genetics, Children's Hospital of Philadelphia , Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Treat+JR%22">Treat JR</searchLink>; Pediatrics, Division of Pediatric Dermatology, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Wood+KH%22">Wood KH</searchLink>; Pathology and Laboratory Medicine, Division of Genomic Diagnostics, Children's Hospital of Philadelphia , Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Lack+J%22">Lack J</searchLink>; NIAID Collaborative Bioinformatics Resource, NIAID , NIH, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Khleborodova+A%22">Khleborodova A</searchLink>; NIAID Collaborative Bioinformatics Resource, NIAID , NIH, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Niemela+JE%22">Niemela JE</searchLink>; Immunology Service, Clinical Center, NIH , Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Yang+X%22">Yang X</searchLink>; Dept. of Paediatrics and Adolescent Medicine, School of Clinical Medicine, The University of Hong Kong , Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Liang+R%22">Liang R</searchLink>; Dept. of Paediatrics and Adolescent Medicine, School of Clinical Medicine, The University of Hong Kong , Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Kui+L%22">Kui L</searchLink>; Dept. of Paediatrics and Adolescent Medicine, School of Clinical Medicine, The University of Hong Kong , Hong Kong, China.; Dept. of Pediatrics, University of California San Diego , La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Wong+CSM%22">Wong CSM</searchLink>; Dept. of Medicine, Divison of Dermatology, The University of Hong Kong , Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Poon+GWK%22">Poon GWK</searchLink>; Dept. of Paediatrics and Adolescent Medicine, Queen Mary Hospital , Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Hoischen+A%22">Hoischen A</searchLink>; Dept. of Human Genetics, Radboud University Medical Center , Nijmegen, Netherlands.<br /><searchLink fieldCode="AU" term="%22van+der+Made+CI%22">van der Made CI</searchLink>; Dept. of Human Genetics, Radboud University Medical Center , Nijmegen, Netherlands.<br /><searchLink fieldCode="AU" term="%22Yang+J%22">Yang J</searchLink>; Dept. of Paediatrics and Adolescent Medicine, School of Clinical Medicine, The University of Hong Kong , Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Chan+KW%22">Chan KW</searchLink>; Dept. of Paediatrics and Adolescent Medicine, School of Clinical Medicine, The University of Hong Kong , Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Rosa+Duque+JSD%22">Rosa Duque JSD</searchLink>; Dept. of Paediatrics and Adolescent Medicine, School of Clinical Medicine, The University of Hong Kong , Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Lee+PPW%22">Lee PPW</searchLink>; Dept. of Paediatrics and Adolescent Medicine, School of Clinical Medicine, The University of Hong Kong , Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Ho+MHK%22">Ho MHK</searchLink>; Dept. of Paediatrics and Adolescent Medicine, School of Clinical Medicine, The University of Hong Kong , Hong Kong, China.; Virtus Medical , Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Chung+BHY%22">Chung BHY</searchLink>; Dept. of Paediatrics and Adolescent Medicine, School of Clinical Medicine, The University of Hong Kong , Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Le+HTM%22">Le HTM</searchLink>; Pediatric Center, Vinmec Times City International General Hospital , Hanoi, Vietnam.<br /><searchLink fieldCode="AU" term="%22Yang+W%22">Yang W</searchLink>; Dept. of Paediatrics and Adolescent Medicine, School of Clinical Medicine, The University of Hong Kong , Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Rohani+P%22">Rohani P</searchLink>; Pediatrics, Pediatric Gastroenterology and Hepatology Research Center, Pediatrics Centre of Excellence, Children's Medical Center, University of Medical Sciences , Tehran, Iran.<br /><searchLink fieldCode="AU" term="%22Fouladvand+A%22">Fouladvand A</searchLink>; Pediatrics, Allergy and Clinical Immunology, Lorestan University of Medical Sciences , Khoramabad, Iran.<br /><searchLink fieldCode="AU" term="%22Rokni-Zadeh+H%22">Rokni-Zadeh H</searchLink>; Dept. of Medical Biotechnology, School of Medicine, Zanjan University of Medical Sciences , Zanjan, Iran.<br /><searchLink fieldCode="AU" term="%22Changi-Ashtiani+M%22">Changi-Ashtiani M</searchLink>; School of Mathematics, Institute for Research in Fundamental Sciences , Tehran, Iran.<br /><searchLink fieldCode="AU" term="%22Miryounesi+M%22">Miryounesi M</searchLink>; Dept. of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences , Tehran, Iran.<br /><searchLink fieldCode="AU" term="%22Puel+A%22">Puel A</searchLink>; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, Necker Hospital for Sick Children, Paris, France.; Imagine Institute, University of Paris-Cité, Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Shahrooei+M%22">Shahrooei M</searchLink>; Microbiology and Immunology, Laboratory of Clinical Bacteriology and Mycology, KU Leuven , Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Finocchi+A%22">Finocchi A</searchLink>; Dept. of System Medicine, Pediatric Chair, University of Tor Vergata, Rome, Italy.; Research Unit of Primary Immunodeficiency, IRCCS Bambin Gesù Children Hospital, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Rossi+P%22">Rossi P</searchLink>; Dept. of System Medicine, Pediatric Chair, University of Tor Vergata, Rome, Italy.; DPUO, Research Unit of Infectivology and Pediatrics Drugs Development, Bambino Gesù Children Hospital IRCCS , Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Rivalta+B%22">Rivalta B</searchLink>; Dept. of System Medicine, Pediatric Chair, University of Tor Vergata, Rome, Italy.; Academic Dept. of Pediatrics (DPUO), Unit of Clinical Immunology and Vaccinology, IRCCS Bambin Gesù Children Hospital, Rome, Italy.; Research Unit of Primary Immunodeficiency, IRCCS Bambin Gesù Children Hospital, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Cifaldi+C%22">Cifaldi C</searchLink>; Research Unit of Primary Immunodeficiency, IRCCS Bambin Gesù Children Hospital, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Novelli+A%22">Novelli A</searchLink>; Laboratory of Medical Genetics, Translational Cytogenomics Research Unit, Bambino Gesù Children Hospital IRCCS , Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Passarelli+C%22">Passarelli C</searchLink>; Laboratory of Medical Genetics, Translational Cytogenomics Research Unit, Bambino Gesù Children Hospital IRCCS , Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Arasi+S%22">Arasi S</searchLink>; Allergy Unit, Area of Translational Research in Pediatric Specialities, Bambino Gesù Children's Hospital, IRCCS , Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Bullens+D%22">Bullens D</searchLink>; Dept. of Microbiology, Immunology and Transplantation, Allergy and Clinical Immunology Research Group, KU Leuven , Leuven, Belgium.; Dept. of Pediatrics, Pediatric Allergy Division, University Hospitals Leuven , Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Sauer+K%22">Sauer K</searchLink>; Dept. of Pediatrics, Pediatric Pulmonology Division, AZ Sint-Jan Brugge , Brugge, Belgium.; Dept. of Pediatrics, Pediatric Pulmonology Division, University Hospitals Leuven , Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Claeys+T%22">Claeys T</searchLink>; Dept. of Pediatrics, Pediatric Gastroenterology Division, AZ Sint-Jan Brugge , Brugge, Belgium.<br /><searchLink fieldCode="AU" term="%22Biggs+CM%22">Biggs CM</searchLink>; Dept. of Pediatrics, BC Children's Hospital, University of British Columbia , Vancouver, Canada.<br /><searchLink fieldCode="AU" term="%22Morris+EC%22">Morris EC</searchLink>; Institute of Immunity and Transplantation, Division of Infection and Immunity, University College London , London, UK.; Dept. of Immunology, Royal Free London NHS Foundation Trust , London, UK.<br /><searchLink fieldCode="AU" term="%22Rosenzweig+SD%22">Rosenzweig SD</searchLink>; Immunology Service, Clinical Center, NIH , Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22O'Shea+JJ%22">O'Shea JJ</searchLink>; Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, NIH , Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Wasserman+WW%22">Wasserman WW</searchLink>; Centre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute , Vancouver, Canada.<br /><searchLink fieldCode="AU" term="%22Bedford+HM%22">Bedford HM</searchLink>; Dept. of Paediatrics, University of Toronto , Toronto, Canada.; Genetics Program, North York General Hospital , Toronto, Canada.<br /><searchLink fieldCode="AU" term="%22van+Karnebeek+CDM%22">van Karnebeek CDM</searchLink>; Centre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute , Vancouver, Canada.; Depts. of Pediatrics and Clinical Genetics, Amsterdam University Medical Centers , Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Palma+P%22">Palma P</searchLink>; Dept. of System Medicine, Pediatric Chair, University of Tor Vergata, Rome, Italy.; Academic Dept. of Pediatrics (DPUO), Unit of Clinical Immunology and Vaccinology, IRCCS Bambin Gesù Children Hospital, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Burns+SO%22">Burns SO</searchLink>; Institute of Immunity and Transplantation, Division of Infection and Immunity, University College London , London, UK.; Dept. of Immunology, Royal Free London NHS Foundation Trust , London, UK.<br /><searchLink fieldCode="AU" term="%22Meyts+I%22">Meyts I</searchLink>; Dept. of Microbiology, Immunology and Transplantation, Laboratory for Inborn Errors of Immunity, KU Leuven , Leuven, Belgium.; Dept. of Pediatrics, Pediatric Immunodeficiencies Division, University Hospitals Leuven , Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Casanova+JL%22">Casanova JL</searchLink>; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, Necker Hospital for Sick Children, Paris, France.; Imagine Institute, University of Paris-Cité, Paris, France.; Howard Hughes Medical Institute, The Rockefeller University, New York, NY, USA.; Department of Pediatrics, Necker Hospital for Sick Children, AP-HP, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Lyons+JJ%22">Lyons JJ</searchLink>; Translational Allergic Immunopathology Unit, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH) , Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Parvaneh+N%22">Parvaneh N</searchLink>; Department of Pediatrics, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.<br /><searchLink fieldCode="AU" term="%22Nguyen+ATV%22">Nguyen ATV</searchLink>; Dept. of Immunology, Allergy and Rheumatology, Division of Primary Immunodeficiency, Vietnam National Children's Hospital , Hanoi, Vietnam.<br /><searchLink fieldCode="AU" term="%22Cancrini+C%22">Cancrini C</searchLink>; Dept. of System Medicine, Pediatric Chair, University of Tor Vergata, Rome, Italy.; Research Unit of Primary Immunodeficiency, IRCCS Bambin Gesù Children Hospital, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Heimall+J%22">Heimall J</searchLink>; Dept. of Pediatrics, Division of Allergy and Immunology, Children's Hospital of Philadelphia , Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Ahmed+H%22">Ahmed H</searchLink>; Faculty of Health Sciences, McMaster University , Hamilton, Canada.<br /><searchLink fieldCode="AU" term="%22McKinnon+ML%22">McKinnon ML</searchLink>; Dept. of Medical Genetics, University of British Columbia , Vancouver, Canada.<br /><searchLink fieldCode="AU" term="%22Lau+YL%22">Lau YL</searchLink>; Dept. of Paediatrics and Adolescent Medicine, School of Clinical Medicine, The University of Hong Kong , Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Béziat+V%22">Béziat V</searchLink>; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, Necker Hospital for Sick Children, Paris, France.; Imagine Institute, University of Paris-Cité, Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Turvey+SE%22">Turvey SE</searchLink>; Dept. of Pediatrics, BC Children's Hospital, University of British Columbia , Vancouver, Canada.
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  Data: <searchLink fieldCode="JN" term="%222985109R%22">The Journal of experimental medicine</searchLink> [J Exp Med] 2023 May 01; Vol. 220 (5). <i>Date of Electronic Publication: </i>2023 Mar 08.
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