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SULT1A1-dependent sulfonation of alkylators is a lineage-dependent vulnerability of liver cancers.

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Title: SULT1A1-dependent sulfonation of alkylators is a lineage-dependent vulnerability of liver cancers.
Authors: Shi L; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.; The Cancer Program, Broad Institute, Cambridge, MA, USA., Shen W; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Davis MI; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, USA., Kong K; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, USA., Vu P; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Saha SK; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Adil R; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Kreuzer J; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Egan R; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Lee TD; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, USA., Greninger P; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Shrimp JH; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, USA., Zhao W; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, USA., Wei TY; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Zhou M; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Eccleston J; Division of Gastroenterology, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Sussman J; Division of Gastroenterology, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Manocha U; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Weerasekara V; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.; The Cancer Program, Broad Institute, Cambridge, MA, USA., Kondo H; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.; The Cancer Program, Broad Institute, Cambridge, MA, USA., Vijay V; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.; The Cancer Program, Broad Institute, Cambridge, MA, USA., Wu MJ; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.; The Cancer Program, Broad Institute, Cambridge, MA, USA., Kearney SE; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, USA., Ho J; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., McClanaghan J; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Murchie E; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Crowther GS; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Patnaik S; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, USA., Boxer MB; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, USA., Shen M; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, USA., Ting DT; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Kim WY; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Stanger BZ; Division of Gastroenterology, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Deshpande V; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Ferrone CR; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Benes CH; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Haas W; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Hall MD; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, USA. hallma@mail.nih.gov., Bardeesy N; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA. bardeesy.nabeel@mgh.harvard.edu.; The Cancer Program, Broad Institute, Cambridge, MA, USA. bardeesy.nabeel@mgh.harvard.edu.
Source: Nature cancer [Nat Cancer] 2023 Mar; Vol. 4 (3), pp. 365-381. Date of Electronic Publication: 2023 Mar 13.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101761119 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2662-1347 (Electronic) Linking ISSN: 26621347 NLM ISO Abbreviation: Nat Cancer Subsets: MEDLINE
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