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Comprehensive molecular phenotyping of ARID1A-deficient gastric cancer reveals pervasive epigenomic reprogramming and therapeutic opportunities.

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Title: Comprehensive molecular phenotyping of ARID1A-deficient gastric cancer reveals pervasive epigenomic reprogramming and therapeutic opportunities.
Authors: Xu C; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore gmstanp@duke-nus.edu.sg sursbyj@nus.edu.sg chang.xu@duke-nus.edu.sg., Huang KK; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Law JH; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Chua JS; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Sheng T; Epigenetic and Epigenomic Regulation, Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore., Flores NM; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Pizzi MP; Department of GI Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Okabe A; Department of Molecular Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan., Tan ALK; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Zhu F; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Kumar V; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Lu X; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Benitez AM; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Lian BSX; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Ma H; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Ho SWT; Epigenetic and Epigenomic Regulation, Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore., Ramnarayanan K; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Anene-Nzelu CG; Cardiovascular Research Institute, National University Health System, Singapore.; Human Genetics, Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore.; Montreal Heart Institute, Quebec, Québec, Canada.; Department of Medicine, University of Montreal, Quebec, Québec, Canada., Razavi-Mohseni M; Department of Biomedical Engineering and McKusick-Nathans Department of Genetic Medicine, Baltimore, Maryland, USA., Abdul Ghani SAB; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Tay ST; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Ong X; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Lee MH; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Guo YA; Computational and Systems Biology, Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore., Ashktorab H; Department of Medicine, Howard University, Washington, DC, USA., Smoot D; Department of Internal Medicine, Meharry Medical College, Nashville, Tennessee, USA., Li S; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore.; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Skanderup AJ; Computational and Systems Biology, Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore., Beer MA; Department of Biomedical Engineering and McKusick-Nathans Department of Genetic Medicine, Baltimore, Maryland, USA., Foo RSY; Cardiovascular Research Institute, National University Health System, Singapore.; Human Genetics, Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore., Wong JSH; Department of General Surgery, Tan Tock Seng Hospital, Singapore., Sanghvi K; Department of General Surgery, Tan Tock Seng Hospital, Singapore., Yong WP; Department of Haematology-Oncology, National University Health System, Singapore.; Cancer Science Institute of Singapore, National University of Singapore, Singapore., Sundar R; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Department of Haematology-Oncology, National University Cancer Institute, Singapore.; The N.1 Institute for Health, National University of Singapore, Singapore.; Singapore Gastric Cancer Consortium, Singapore., Kaneda A; Department of Molecular Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan., Prabhakar S; Computational and Systems Biology, Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore., Mazur PK; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Ajani JA; Department of GI Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Yeoh KG; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Singapore Gastric Cancer Consortium, Singapore.; Department of Gastroenterology and Hepatology, National University Health System, Singapore., So JB; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore gmstanp@duke-nus.edu.sg sursbyj@nus.edu.sg chang.xu@duke-nus.edu.sg.; Singapore Gastric Cancer Consortium, Singapore.; Division of Surgical Oncology, National University Cancer Institute, Singapore., Tan P; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore gmstanp@duke-nus.edu.sg sursbyj@nus.edu.sg chang.xu@duke-nus.edu.sg.; Epigenetic and Epigenomic Regulation, Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore.; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Cancer Science Institute of Singapore, National University of Singapore, Singapore.; Singapore Gastric Cancer Consortium, Singapore.; SingHealth/Duke-NUS Institute of Precision Medicine, National Heart Centre Singapore, Singapore.; Cellular and Molecular Research, National Cancer Centre, Singapore.
Corporate Authors: Singapore Gastric Cancer Consortium
Source: Gut [Gut] 2023 Sep; Vol. 72 (9), pp. 1651-1663. Date of Electronic Publication: 2023 Mar 14.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: British Medical Assn Country of Publication: England NLM ID: 2985108R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1468-3288 (Electronic) Linking ISSN: 00175749 NLM ISO Abbreviation: Gut Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
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PubType: Academic Journal
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  Data: Comprehensive molecular phenotyping of ARID1A-deficient gastric cancer reveals pervasive epigenomic reprogramming and therapeutic opportunities.
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  Data: <searchLink fieldCode="AU" term="%22Xu+C%22">Xu C</searchLink>; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore gmstanp@duke-nus.edu.sg sursbyj@nus.edu.sg chang.xu@duke-nus.edu.sg.<br /><searchLink fieldCode="AU" term="%22Huang+KK%22">Huang KK</searchLink>; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore.<br /><searchLink fieldCode="AU" term="%22Law+JH%22">Law JH</searchLink>; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Chua+JS%22">Chua JS</searchLink>; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Sheng+T%22">Sheng T</searchLink>; Epigenetic and Epigenomic Regulation, Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore.<br /><searchLink fieldCode="AU" term="%22Flores+NM%22">Flores NM</searchLink>; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Pizzi+MP%22">Pizzi MP</searchLink>; Department of GI Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Okabe+A%22">Okabe A</searchLink>; Department of Molecular Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan.<br /><searchLink fieldCode="AU" term="%22Tan+ALK%22">Tan ALK</searchLink>; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore.<br /><searchLink fieldCode="AU" term="%22Zhu+F%22">Zhu F</searchLink>; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Kumar+V%22">Kumar V</searchLink>; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore.<br /><searchLink fieldCode="AU" term="%22Lu+X%22">Lu X</searchLink>; 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Cardiovascular Research Institute, National University Health System, Singapore.; Human Genetics, Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore.; Montreal Heart Institute, Quebec, Québec, Canada.; Department of Medicine, University of Montreal, Quebec, Québec, Canada.<br /><searchLink fieldCode="AU" term="%22Razavi-Mohseni+M%22">Razavi-Mohseni M</searchLink>; Department of Biomedical Engineering and McKusick-Nathans Department of Genetic Medicine, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Abdul+Ghani+SAB%22">Abdul Ghani SAB</searchLink>; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore.<br /><searchLink fieldCode="AU" term="%22Tay+ST%22">Tay ST</searchLink>; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore.<br /><searchLink fieldCode="AU" term="%22Ong+X%22">Ong X</searchLink>; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore.<br /><searchLink fieldCode="AU" term="%22Lee+MH%22">Lee MH</searchLink>; 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Department of Biomedical Engineering and McKusick-Nathans Department of Genetic Medicine, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Foo+RSY%22">Foo RSY</searchLink>; Cardiovascular Research Institute, National University Health System, Singapore.; Human Genetics, Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore.<br /><searchLink fieldCode="AU" term="%22Wong+JSH%22">Wong JSH</searchLink>; Department of General Surgery, Tan Tock Seng Hospital, Singapore.<br /><searchLink fieldCode="AU" term="%22Sanghvi+K%22">Sanghvi K</searchLink>; Department of General Surgery, Tan Tock Seng Hospital, Singapore.<br /><searchLink fieldCode="AU" term="%22Yong+WP%22">Yong WP</searchLink>; Department of Haematology-Oncology, National University Health System, Singapore.; Cancer Science Institute of Singapore, National University of Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Sundar+R%22">Sundar R</searchLink>; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Department of Haematology-Oncology, National University Cancer Institute, Singapore.; The N.1 Institute for Health, National University of Singapore, Singapore.; Singapore Gastric Cancer Consortium, Singapore.<br /><searchLink fieldCode="AU" term="%22Kaneda+A%22">Kaneda A</searchLink>; Department of Molecular Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan.<br /><searchLink fieldCode="AU" term="%22Prabhakar+S%22">Prabhakar S</searchLink>; Computational and Systems Biology, Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore.<br /><searchLink fieldCode="AU" term="%22Mazur+PK%22">Mazur PK</searchLink>; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Ajani+JA%22">Ajani JA</searchLink>; Department of GI Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Yeoh+KG%22">Yeoh KG</searchLink>; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Singapore Gastric Cancer Consortium, Singapore.; Department of Gastroenterology and Hepatology, National University Health System, Singapore.<br /><searchLink fieldCode="AU" term="%22So+JB%22">So JB</searchLink>; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore gmstanp@duke-nus.edu.sg sursbyj@nus.edu.sg chang.xu@duke-nus.edu.sg.; Singapore Gastric Cancer Consortium, Singapore.; Division of Surgical Oncology, National University Cancer Institute, Singapore.<br /><searchLink fieldCode="AU" term="%22Tan+P%22">Tan P</searchLink>; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore gmstanp@duke-nus.edu.sg sursbyj@nus.edu.sg chang.xu@duke-nus.edu.sg.; Epigenetic and Epigenomic Regulation, Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore.; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Cancer Science Institute of Singapore, National University of Singapore, Singapore.; Singapore Gastric Cancer Consortium, Singapore.; SingHealth/Duke-NUS Institute of Precision Medicine, National Heart Centre Singapore, Singapore.; Cellular and Molecular Research, National Cancer Centre, Singapore.
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