Comprehensive molecular phenotyping of ARID1A-deficient gastric cancer reveals pervasive epigenomic reprogramming and therapeutic opportunities.
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| Title: | Comprehensive molecular phenotyping of ARID1A-deficient gastric cancer reveals pervasive epigenomic reprogramming and therapeutic opportunities. |
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| Authors: | Xu C; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore gmstanp@duke-nus.edu.sg sursbyj@nus.edu.sg chang.xu@duke-nus.edu.sg., Huang KK; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Law JH; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Chua JS; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Sheng T; Epigenetic and Epigenomic Regulation, Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore., Flores NM; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Pizzi MP; Department of GI Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Okabe A; Department of Molecular Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan., Tan ALK; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Zhu F; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Kumar V; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Lu X; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Benitez AM; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Lian BSX; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Ma H; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Ho SWT; Epigenetic and Epigenomic Regulation, Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore., Ramnarayanan K; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Anene-Nzelu CG; Cardiovascular Research Institute, National University Health System, Singapore.; Human Genetics, Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore.; Montreal Heart Institute, Quebec, Québec, Canada.; Department of Medicine, University of Montreal, Quebec, Québec, Canada., Razavi-Mohseni M; Department of Biomedical Engineering and McKusick-Nathans Department of Genetic Medicine, Baltimore, Maryland, USA., Abdul Ghani SAB; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Tay ST; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Ong X; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Lee MH; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Guo YA; Computational and Systems Biology, Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore., Ashktorab H; Department of Medicine, Howard University, Washington, DC, USA., Smoot D; Department of Internal Medicine, Meharry Medical College, Nashville, Tennessee, USA., Li S; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore.; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Skanderup AJ; Computational and Systems Biology, Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore., Beer MA; Department of Biomedical Engineering and McKusick-Nathans Department of Genetic Medicine, Baltimore, Maryland, USA., Foo RSY; Cardiovascular Research Institute, National University Health System, Singapore.; Human Genetics, Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore., Wong JSH; Department of General Surgery, Tan Tock Seng Hospital, Singapore., Sanghvi K; Department of General Surgery, Tan Tock Seng Hospital, Singapore., Yong WP; Department of Haematology-Oncology, National University Health System, Singapore.; Cancer Science Institute of Singapore, National University of Singapore, Singapore., Sundar R; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Department of Haematology-Oncology, National University Cancer Institute, Singapore.; The N.1 Institute for Health, National University of Singapore, Singapore.; Singapore Gastric Cancer Consortium, Singapore., Kaneda A; Department of Molecular Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan., Prabhakar S; Computational and Systems Biology, Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore., Mazur PK; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Ajani JA; Department of GI Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Yeoh KG; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Singapore Gastric Cancer Consortium, Singapore.; Department of Gastroenterology and Hepatology, National University Health System, Singapore., So JB; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore gmstanp@duke-nus.edu.sg sursbyj@nus.edu.sg chang.xu@duke-nus.edu.sg.; Singapore Gastric Cancer Consortium, Singapore.; Division of Surgical Oncology, National University Cancer Institute, Singapore., Tan P; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore gmstanp@duke-nus.edu.sg sursbyj@nus.edu.sg chang.xu@duke-nus.edu.sg.; Epigenetic and Epigenomic Regulation, Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore.; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Cancer Science Institute of Singapore, National University of Singapore, Singapore.; Singapore Gastric Cancer Consortium, Singapore.; SingHealth/Duke-NUS Institute of Precision Medicine, National Heart Centre Singapore, Singapore.; Cellular and Molecular Research, National Cancer Centre, Singapore. |
| Corporate Authors: | Singapore Gastric Cancer Consortium |
| Source: | Gut [Gut] 2023 Sep; Vol. 72 (9), pp. 1651-1663. Date of Electronic Publication: 2023 Mar 14. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: British Medical Assn Country of Publication: England NLM ID: 2985108R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1468-3288 (Electronic) Linking ISSN: 00175749 NLM ISO Abbreviation: Gut Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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