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A Phase II Trial of Guadecitabine plus Atezolizumab in Metastatic Urothelial Carcinoma Progressing after Initial Immune Checkpoint Inhibitor Therapy.

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Title: A Phase II Trial of Guadecitabine plus Atezolizumab in Metastatic Urothelial Carcinoma Progressing after Initial Immune Checkpoint Inhibitor Therapy.
Authors: Jang HJ; Department of Epigenetics, Van Andel Institute, Grand Rapids, Michigan., Hostetter G; Pathology and Biorepository Core, Van Andel Institute, Grand Rapids, Michigan., Macfarlane AW; Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania., Madaj Z; Bioinformatics & Biostatistics Core, Van Andel Institute, Grand Rapids, Michigan., Ross EA; Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania., Hinoue T; Department of Epigenetics, Van Andel Institute, Grand Rapids, Michigan., Kulchycki JR; Department of Epigenetics, Van Andel Institute, Grand Rapids, Michigan., Burgos RS; Department of Epigenetics, Van Andel Institute, Grand Rapids, Michigan., Tafseer M; Department of Hematology/Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania., Alpaugh RK; Department of Hematology/Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania., Schwebel CL; Department of Hematology/Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania., Kokate R; Department of Hematology/Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania., Geynisman DM; Department of Hematology/Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania., Zibelman MR; Department of Hematology/Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania., Ghatalia P; Department of Hematology/Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania., Nichols PW; Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California., Chung W; The Coriell Institute for Medical Research, Camden, New Jersey., Madzo J; The Coriell Institute for Medical Research, Camden, New Jersey., Hahn NM; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, Maryland., Quinn DI; University of Southern California Norris Comprehensive Cancer Center, Keck School of Medicine of USC, Los Angeles, California., Issa JJ; The Coriell Institute for Medical Research, Camden, New Jersey., Topper MJ; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, Maryland., Baylin SB; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, Maryland., Shen H; Department of Epigenetics, Van Andel Institute, Grand Rapids, Michigan., Campbell KS; Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania., Jones PA; Department of Epigenetics, Van Andel Institute, Grand Rapids, Michigan., Plimack ER; Department of Hematology/Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania.
Source: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2023 Jun 01; Vol. 29 (11), pp. 2052-2065.
Publication Type: Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 9502500 Publication Model: Print Cited Medium: Internet ISSN: 1557-3265 (Electronic) Linking ISSN: 10780432 NLM ISO Abbreviation: Clin Cancer Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A Phase II Trial of Guadecitabine plus Atezolizumab in Metastatic Urothelial Carcinoma Progressing after Initial Immune Checkpoint Inhibitor Therapy.
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  Data: <searchLink fieldCode="AU" term="%22Jang+HJ%22">Jang HJ</searchLink>; Department of Epigenetics, Van Andel Institute, Grand Rapids, Michigan.<br /><searchLink fieldCode="AU" term="%22Hostetter+G%22">Hostetter G</searchLink>; Pathology and Biorepository Core, Van Andel Institute, Grand Rapids, Michigan.<br /><searchLink fieldCode="AU" term="%22Macfarlane+AW%22">Macfarlane AW</searchLink>; Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Madaj+Z%22">Madaj Z</searchLink>; Bioinformatics & Biostatistics Core, Van Andel Institute, Grand Rapids, Michigan.<br /><searchLink fieldCode="AU" term="%22Ross+EA%22">Ross EA</searchLink>; Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Hinoue+T%22">Hinoue T</searchLink>; Department of Epigenetics, Van Andel Institute, Grand Rapids, Michigan.<br /><searchLink fieldCode="AU" term="%22Kulchycki+JR%22">Kulchycki JR</searchLink>; Department of Epigenetics, Van Andel Institute, Grand Rapids, Michigan.<br /><searchLink fieldCode="AU" term="%22Burgos+RS%22">Burgos RS</searchLink>; Department of Epigenetics, Van Andel Institute, Grand Rapids, Michigan.<br /><searchLink fieldCode="AU" term="%22Tafseer+M%22">Tafseer M</searchLink>; Department of Hematology/Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Alpaugh+RK%22">Alpaugh RK</searchLink>; Department of Hematology/Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Schwebel+CL%22">Schwebel CL</searchLink>; Department of Hematology/Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Kokate+R%22">Kokate R</searchLink>; Department of Hematology/Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Geynisman+DM%22">Geynisman DM</searchLink>; Department of Hematology/Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Zibelman+MR%22">Zibelman MR</searchLink>; Department of Hematology/Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Ghatalia+P%22">Ghatalia P</searchLink>; Department of Hematology/Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Nichols+PW%22">Nichols PW</searchLink>; Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California.<br /><searchLink fieldCode="AU" term="%22Chung+W%22">Chung W</searchLink>; The Coriell Institute for Medical Research, Camden, New Jersey.<br /><searchLink fieldCode="AU" term="%22Madzo+J%22">Madzo J</searchLink>; The Coriell Institute for Medical Research, Camden, New Jersey.<br /><searchLink fieldCode="AU" term="%22Hahn+NM%22">Hahn NM</searchLink>; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, Maryland.<br /><searchLink fieldCode="AU" term="%22Quinn+DI%22">Quinn DI</searchLink>; University of Southern California Norris Comprehensive Cancer Center, Keck School of Medicine of USC, Los Angeles, California.<br /><searchLink fieldCode="AU" term="%22Issa+JJ%22">Issa JJ</searchLink>; The Coriell Institute for Medical Research, Camden, New Jersey.<br /><searchLink fieldCode="AU" term="%22Topper+MJ%22">Topper MJ</searchLink>; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, Maryland.<br /><searchLink fieldCode="AU" term="%22Baylin+SB%22">Baylin SB</searchLink>; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, Maryland.<br /><searchLink fieldCode="AU" term="%22Shen+H%22">Shen H</searchLink>; Department of Epigenetics, Van Andel Institute, Grand Rapids, Michigan.<br /><searchLink fieldCode="AU" term="%22Campbell+KS%22">Campbell KS</searchLink>; Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Jones+PA%22">Jones PA</searchLink>; Department of Epigenetics, Van Andel Institute, Grand Rapids, Michigan.<br /><searchLink fieldCode="AU" term="%22Plimack+ER%22">Plimack ER</searchLink>; Department of Hematology/Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania.
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  Data: <searchLink fieldCode="JN" term="%229502500%22">Clinical cancer research : an official journal of the American Association for Cancer Research</searchLink> [Clin Cancer Res] 2023 Jun 01; Vol. 29 (11), pp. 2052-2065.
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  Data: Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+Cancer+Research%22">American Association for Cancer Research </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9502500 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1557-3265 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210780432%22">10780432 </searchLink><i>NLM ISO Abbreviation: </i>Clin Cancer Res <i>Subsets: </i>MEDLINE
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              Text: 2023 Jun 01
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