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Efficacy and Safety of Early Administration of 4-Factor Prothrombin Complex Concentrate in Patients With Trauma at Risk of Massive Transfusion: The PROCOAG Randomized Clinical Trial.

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Title: Efficacy and Safety of Early Administration of 4-Factor Prothrombin Complex Concentrate in Patients With Trauma at Risk of Massive Transfusion: The PROCOAG Randomized Clinical Trial.
Authors: Bouzat P; Université Grenoble Alpes, Inserm, U1216, CHU Grenoble Alpes, Grenoble Institute Neurosciences, Grenoble, France., Charbit J; Trauma Critical Care Unit, Montpellier University Hospital, F-34295 Montpellier Cedex 5, France., Abback PS; Department of Anesthesiology and Critical Care, Beaujon Hospital, DMU Parabol, AP-HP. Nord, Clichy, France., Huet-Garrigue D; Department of Anesthesiology and Critical Care, Centre Hospitalier Universitaire Lille, Surgical Critical Care, Lille, France., Delhaye N; AP-HP, Groupe Hospitalier Universitaire APHP-Sorbonne Université, site Pitié-Salpêtrière, Département d'Anesthésie Réanimation, Paris, France., Leone M; Aix Marseille University, Assistance Publique Hôpitaux Universitaires de Marseille, Department of Anesthesiology and Intensive Care Unit, North Hospital, and Centre for CardioVascular and Nutrition Research (C2VN), Inserm 1263, Inrae 1260, Marseille, France., Marcotte G; Hospices Civils de Lyon, Hopital Edouard Herriot, Department of Anesthesia and Intensive Care, Lyon, France., David JS; University Claude Bernard Lyon 1, INSERM U1290, Research on Healthcare Performance (RESHAPE), and Hospices Civils de Lyon, Groupement Hospitalier Sud, Department of Anesthesia and Intensive Care, Pierre Benite, France., Levrat A; Intensive care unit, Annecy Hospital, Annecy, France., Asehnoune K; Université de Nantes, CHU Nantes, Pôle anesthésie réanimations, Service d'Anesthésie Réanimation chirurgicale, Hôtel Dieu, Nantes, France., Pottecher J; Hôpitaux Universitaires de Strasbourg, Hôpital de Hautepierre, Service d'Anesthésie-Réanimation & Médecine Péri-Opératoire - Université de Strasbourg, Faculté de Médecine, FMTS, ER3072, Strasbourg, France., Duranteau J; Département d'Anesthésie-Réanimation, Hôpitaux Universitaires Paris Sud, Université Paris XI, Faculté de Médecine Paris-Sud, Le Kremlin-Bicêtre, France., Courvalin E; Trauma Critical Care Unit, Montpellier University Hospital, F-34295 Montpellier Cedex 5, France., Adolle A; Pôle d'Anesthésie-Réanimation, CHU Grenoble Alpes, Grenoble, France., Sourd D; Univ. Grenoble Alpes, CNRS, Public Health department CHU Grenoble Alpes, TIMC-IMAG, Grenoble, France., Bosson JL; Univ. Grenoble Alpes, CNRS, Public Health department CHU Grenoble Alpes, TIMC-IMAG, Grenoble, France., Riou B; Sorbonne Université, UMR-S INSERM 1166, IHU ICAN, and Assistance Publique-Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Department of Emergency medicine and Surgery, Paris, France., Gauss T; Department of Anesthesiology and Critical Care, Beaujon Hospital, DMU Parabol, AP-HP. Nord, Clichy, France., Payen JF; Université Grenoble Alpes, Inserm, U1216, CHU Grenoble Alpes, Grenoble Institute Neurosciences, Grenoble, France.
Corporate Authors: PROCOAG Study Group
Source: JAMA [JAMA] 2023 Apr 25; Vol. 329 (16), pp. 1367-1375.
Publication Type: Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Equivalence Trial
Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 7501160 Publication Model: Print Cited Medium: Internet ISSN: 1538-3598 (Electronic) Linking ISSN: 00987484 NLM ISO Abbreviation: JAMA Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Efficacy and Safety of Early Administration of 4-Factor Prothrombin Complex Concentrate in Patients With Trauma at Risk of Massive Transfusion: The PROCOAG Randomized Clinical Trial.
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  Data: <searchLink fieldCode="AU" term="%22Bouzat+P%22">Bouzat P</searchLink>; Université Grenoble Alpes, Inserm, U1216, CHU Grenoble Alpes, Grenoble Institute Neurosciences, Grenoble, France.<br /><searchLink fieldCode="AU" term="%22Charbit+J%22">Charbit J</searchLink>; Trauma Critical Care Unit, Montpellier University Hospital, F-34295 Montpellier Cedex 5, France.<br /><searchLink fieldCode="AU" term="%22Abback+PS%22">Abback PS</searchLink>; Department of Anesthesiology and Critical Care, Beaujon Hospital, DMU Parabol, AP-HP. Nord, Clichy, France.<br /><searchLink fieldCode="AU" term="%22Huet-Garrigue+D%22">Huet-Garrigue D</searchLink>; Department of Anesthesiology and Critical Care, Centre Hospitalier Universitaire Lille, Surgical Critical Care, Lille, France.<br /><searchLink fieldCode="AU" term="%22Delhaye+N%22">Delhaye N</searchLink>; AP-HP, Groupe Hospitalier Universitaire APHP-Sorbonne Université, site Pitié-Salpêtrière, Département d'Anesthésie Réanimation, Paris, France.<br /><searchLink fieldCode="AU" term="%22Leone+M%22">Leone M</searchLink>; Aix Marseille University, Assistance Publique Hôpitaux Universitaires de Marseille, Department of Anesthesiology and Intensive Care Unit, North Hospital, and Centre for CardioVascular and Nutrition Research (C2VN), Inserm 1263, Inrae 1260, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Marcotte+G%22">Marcotte G</searchLink>; Hospices Civils de Lyon, Hopital Edouard Herriot, Department of Anesthesia and Intensive Care, Lyon, France.<br /><searchLink fieldCode="AU" term="%22David+JS%22">David JS</searchLink>; University Claude Bernard Lyon 1, INSERM U1290, Research on Healthcare Performance (RESHAPE), and Hospices Civils de Lyon, Groupement Hospitalier Sud, Department of Anesthesia and Intensive Care, Pierre Benite, France.<br /><searchLink fieldCode="AU" term="%22Levrat+A%22">Levrat A</searchLink>; Intensive care unit, Annecy Hospital, Annecy, France.<br /><searchLink fieldCode="AU" term="%22Asehnoune+K%22">Asehnoune K</searchLink>; Université de Nantes, CHU Nantes, Pôle anesthésie réanimations, Service d'Anesthésie Réanimation chirurgicale, Hôtel Dieu, Nantes, France.<br /><searchLink fieldCode="AU" term="%22Pottecher+J%22">Pottecher J</searchLink>; Hôpitaux Universitaires de Strasbourg, Hôpital de Hautepierre, Service d'Anesthésie-Réanimation & Médecine Péri-Opératoire - Université de Strasbourg, Faculté de Médecine, FMTS, ER3072, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Duranteau+J%22">Duranteau J</searchLink>; Département d'Anesthésie-Réanimation, Hôpitaux Universitaires Paris Sud, Université Paris XI, Faculté de Médecine Paris-Sud, Le Kremlin-Bicêtre, France.<br /><searchLink fieldCode="AU" term="%22Courvalin+E%22">Courvalin E</searchLink>; Trauma Critical Care Unit, Montpellier University Hospital, F-34295 Montpellier Cedex 5, France.<br /><searchLink fieldCode="AU" term="%22Adolle+A%22">Adolle A</searchLink>; Pôle d'Anesthésie-Réanimation, CHU Grenoble Alpes, Grenoble, France.<br /><searchLink fieldCode="AU" term="%22Sourd+D%22">Sourd D</searchLink>; Univ. Grenoble Alpes, CNRS, Public Health department CHU Grenoble Alpes, TIMC-IMAG, Grenoble, France.<br /><searchLink fieldCode="AU" term="%22Bosson+JL%22">Bosson JL</searchLink>; Univ. Grenoble Alpes, CNRS, Public Health department CHU Grenoble Alpes, TIMC-IMAG, Grenoble, France.<br /><searchLink fieldCode="AU" term="%22Riou+B%22">Riou B</searchLink>; Sorbonne Université, UMR-S INSERM 1166, IHU ICAN, and Assistance Publique-Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Department of Emergency medicine and Surgery, Paris, France.<br /><searchLink fieldCode="AU" term="%22Gauss+T%22">Gauss T</searchLink>; Department of Anesthesiology and Critical Care, Beaujon Hospital, DMU Parabol, AP-HP. Nord, Clichy, France.<br /><searchLink fieldCode="AU" term="%22Payen+JF%22">Payen JF</searchLink>; Université Grenoble Alpes, Inserm, U1216, CHU Grenoble Alpes, Grenoble Institute Neurosciences, Grenoble, France.
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