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EXT418, a novel long-acting ghrelin, mitigates Lewis lung carcinoma induced cachexia in mice.

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Title: EXT418, a novel long-acting ghrelin, mitigates Lewis lung carcinoma induced cachexia in mice.
Authors: Kerr HL; Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA.; Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Washington School of Medicine, Washington, Seattle, USA., Krumm K; Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA.; Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Washington School of Medicine, Washington, Seattle, USA., Lee II; Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA.; Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Washington School of Medicine, Washington, Seattle, USA., Anderson B; Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA.; Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Washington School of Medicine, Washington, Seattle, USA., Christiani A; Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA.; Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Washington School of Medicine, Washington, Seattle, USA., Strait L; Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA.; Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Washington School of Medicine, Washington, Seattle, USA., Breckheimer BA; Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA.; Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Washington School of Medicine, Washington, Seattle, USA., Irwin B; Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA.; Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Washington School of Medicine, Washington, Seattle, USA., Jiang AS; Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA.; Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Washington School of Medicine, Washington, Seattle, USA., Rybachok A; Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA.; Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Washington School of Medicine, Washington, Seattle, USA., Chen A; Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA.; Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Washington School of Medicine, Washington, Seattle, USA., Caeiro L; Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA.; Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Washington School of Medicine, Washington, Seattle, USA., Dacek E; Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA.; Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Washington School of Medicine, Washington, Seattle, USA., Hall DB; Extend Biosciences, Inc., St. Newton, Massachusetts, USA., Kostyla CH; Extend Biosciences, Inc., St. Newton, Massachusetts, USA.; Atalanta Therapeutics, Boston, Massachusetts, USA., Hales LM; Extend Biosciences, Inc., St. Newton, Massachusetts, USA., Soliman TM; Extend Biosciences, Inc., St. Newton, Massachusetts, USA., Garcia JM; Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA.; Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Washington School of Medicine, Washington, Seattle, USA.
Source: Journal of cachexia, sarcopenia and muscle [J Cachexia Sarcopenia Muscle] 2023 Jun; Vol. 14 (3), pp. 1337-1348. Date of Electronic Publication: 2023 Mar 21.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: John Wiley & Sons Ltd on behalf of Society on Sarcopenia, Cachexia and Wasting Disorders Country of Publication: Germany NLM ID: 101552883 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2190-6009 (Electronic) Linking ISSN: 21905991 NLM ISO Abbreviation: J Cachexia Sarcopenia Muscle Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: EXT418, a novel long-acting ghrelin, mitigates Lewis lung carcinoma induced cachexia in mice.
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  Data: <searchLink fieldCode="AU" term="%22Kerr+HL%22">Kerr HL</searchLink>; Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA.; Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Washington School of Medicine, Washington, Seattle, USA.<br /><searchLink fieldCode="AU" term="%22Krumm+K%22">Krumm K</searchLink>; Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA.; Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Washington School of Medicine, Washington, Seattle, USA.<br /><searchLink fieldCode="AU" term="%22Lee+II%22">Lee II</searchLink>; Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA.; Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Washington School of Medicine, Washington, Seattle, USA.<br /><searchLink fieldCode="AU" term="%22Anderson+B%22">Anderson B</searchLink>; Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA.; Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Washington School of Medicine, Washington, Seattle, USA.<br /><searchLink fieldCode="AU" term="%22Christiani+A%22">Christiani A</searchLink>; Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA.; Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Washington School of Medicine, Washington, Seattle, USA.<br /><searchLink fieldCode="AU" term="%22Strait+L%22">Strait L</searchLink>; Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA.; Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Washington School of Medicine, Washington, Seattle, USA.<br /><searchLink fieldCode="AU" term="%22Breckheimer+BA%22">Breckheimer BA</searchLink>; Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA.; Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Washington School of Medicine, Washington, Seattle, USA.<br /><searchLink fieldCode="AU" term="%22Irwin+B%22">Irwin B</searchLink>; Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA.; Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Washington School of Medicine, Washington, Seattle, USA.<br /><searchLink fieldCode="AU" term="%22Jiang+AS%22">Jiang AS</searchLink>; Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA.; Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Washington School of Medicine, Washington, Seattle, USA.<br /><searchLink fieldCode="AU" term="%22Rybachok+A%22">Rybachok A</searchLink>; Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA.; Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Washington School of Medicine, Washington, Seattle, USA.<br /><searchLink fieldCode="AU" term="%22Chen+A%22">Chen A</searchLink>; Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA.; Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Washington School of Medicine, Washington, Seattle, USA.<br /><searchLink fieldCode="AU" term="%22Caeiro+L%22">Caeiro L</searchLink>; Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA.; Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Washington School of Medicine, Washington, Seattle, USA.<br /><searchLink fieldCode="AU" term="%22Dacek+E%22">Dacek E</searchLink>; Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA.; Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Washington School of Medicine, Washington, Seattle, USA.<br /><searchLink fieldCode="AU" term="%22Hall+DB%22">Hall DB</searchLink>; Extend Biosciences, Inc., St. Newton, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Kostyla+CH%22">Kostyla CH</searchLink>; Extend Biosciences, Inc., St. Newton, Massachusetts, USA.; Atalanta Therapeutics, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Hales+LM%22">Hales LM</searchLink>; Extend Biosciences, Inc., St. Newton, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Soliman+TM%22">Soliman TM</searchLink>; Extend Biosciences, Inc., St. Newton, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Garcia+JM%22">Garcia JM</searchLink>; Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA.; Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Washington School of Medicine, Washington, Seattle, USA.
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        Value: 10.1002/jcsm.13211
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        Text: English
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              Text: 2023 Jun
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