Cross-ancestry, cell-type-informed atlas of gene, isoform, and splicing regulation in the developing human brain.
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| Title: | Cross-ancestry, cell-type-informed atlas of gene, isoform, and splicing regulation in the developing human brain. |
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| Authors: | Wen C; Interdepartmental Program in Bioinformatics, University of California, Los Angeles; Los Angeles, CA, 90095, USA.; Department of Psychiatry, David Geffen School of Medicine, University of California, Los Angeles; Los Angeles, CA, 90095, USA.; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles; Los Angeles, CA, 90095, USA., Margolis M; Department of Psychiatry, David Geffen School of Medicine, University of California, Los Angeles; Los Angeles, CA, 90095, USA.; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles; Los Angeles, CA, 90095, USA., Dai R; Department of Psychiatry, SUNY Upstate Medical University; Syracuse, NY, 13210, USA., Zhang P; Department of Psychiatry, David Geffen School of Medicine, University of California, Los Angeles; Los Angeles, CA, 90095, USA.; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles; Los Angeles, CA, 90095, USA., Przytycki PF; Gladstone Institute of Data Science and Biotechnology; San Francisco, CA, 94158, USA., Vo DD; Department of Psychiatry, David Geffen School of Medicine, University of California, Los Angeles; Los Angeles, CA, 90095, USA.; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles; Los Angeles, CA, 90095, USA.; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA, 19104, USA.; Lifespan Brain Institute, The Children's Hospital of Philadelphia; Philadelphia, PA, 19104, USA., Bhattacharya A; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles; Los Angeles, CA, 90095, USA.; Institute for Quantitative and Computational Biosciences, David Geffen School of Medicine, University of California, Los Angeles; Los Angeles, CA, 90095, USA., Matoba N; Department of Genetics, University of North Carolina at Chapel Hill; Chapel Hill, NC, 27599, USA.; UNC Neuroscience Center, University of North Carolina at Chapel Hill; Chapel Hill, NC, 27599, USA., Jiao C; Department of Psychiatry, SUNY Upstate Medical University; Syracuse, NY, 13210, USA., Kim M; Department of Psychiatry, David Geffen School of Medicine, University of California, Los Angeles; Los Angeles, CA, 90095, USA.; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles; Los Angeles, CA, 90095, USA., Tsai E; Department of Psychiatry, David Geffen School of Medicine, University of California, Los Angeles; Los Angeles, CA, 90095, USA.; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles; Los Angeles, CA, 90095, USA., Hoh C; Department of Psychiatry, David Geffen School of Medicine, University of California, Los Angeles; Los Angeles, CA, 90095, USA.; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles; Los Angeles, CA, 90095, USA., Aygün N; Department of Genetics, University of North Carolina at Chapel Hill; Chapel Hill, NC, 27599, USA.; UNC Neuroscience Center, University of North Carolina at Chapel Hill; Chapel Hill, NC, 27599, USA., Walker RL; Interdepartmental Program in Bioinformatics, University of California, Los Angeles; Los Angeles, CA, 90095, USA.; Department of Psychiatry, David Geffen School of Medicine, University of California, Los Angeles; Los Angeles, CA, 90095, USA.; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles; Los Angeles, CA, 90095, USA., Chatzinakos C; Department of Psychiatry, Harvard Medical School; Boston, MA, 02215, USA.; McLean Hospital; Belmont, MA, 02478, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard; Cambridge, MA, 02142, USA., Clarke D; Department of Molecular Biophysics and Biochemistry, Yale University; New Haven, CT, 06520, USA., Pratt H; Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School; Worcester, MA, 01605, USA., Consortium P; Interdepartmental Program in Bioinformatics, University of California, Los Angeles; Los Angeles, CA, 90095, USA.; Department of Psychiatry, David Geffen School of Medicine, University of California, Los Angeles; Los Angeles, CA, 90095, USA.; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles; Los Angeles, CA, 90095, USA.; Department of Psychiatry, SUNY Upstate Medical University; Syracuse, NY, 13210, USA.; Gladstone Institute of Data Science and Biotechnology; San Francisco, CA, 94158, USA.; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA, 19104, USA.; Lifespan Brain Institute, The Children's Hospital of Philadelphia; Philadelphia, PA, 19104, USA.; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles; Los Angeles, CA, 90095, USA.; Institute for Quantitative and Computational Biosciences, David Geffen School of Medicine, University of California, Los Angeles; Los Angeles, CA, 90095, USA.; Department of Genetics, University of North Carolina at Chapel Hill; Chapel Hill, NC, 27599, USA.; UNC Neuroscience Center, University of North Carolina at Chapel Hill; Chapel Hill, NC, 27599, USA.; Department of Psychiatry, Harvard Medical School; Boston, MA, 02215, USA.; McLean Hospital; Belmont, MA, 02478, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard; Cambridge, MA, 02142, USA.; Department of Molecular Biophysics and Biochemistry, Yale University; New Haven, CT, 06520, USA.; Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School; Worcester, MA, 01605, USA.; CNS Data Coordination Group, Sage Bionetworks; Seattle, WA, 98109, USA.; Program in Computational Biology and Bioinformatics, Yale University; New Haven, CT, 06520, USA.; Department of Computer Science, Yale University; New Haven, CT, 06520, USA.; Department of Statistics and Data Science, Yale University; New Haven, CT, 06520, USA.; Lieber Institute for Brain Development; Baltimore, MD, 21205, USA.; Department of Psychiatry & Behavioral Sciences, Johns Hopkins University School of Medicine; Baltimore, MD, 21205, USA.; Department of Neuroscience, Johns Hopkins University School of Medicine; Baltimore, MD, 21205, USA.; Department of Genetic Medicine, Johns Hopkins University School of Medicine; Baltimore, MD, 21205, USA.; Department of Mental Health, Johns Hopkins Bloomberg School of Public Health; Baltimore, MD, 21205, USA.; Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health; Baltimore, MD, 21205, USA.; Neumora Therapeutics; Watertown, MA, 02472, USA.; Department of Neurology, Johns Hopkins University School of Medicine; Baltimore, MD, 21205, USA.; MRC Centre for Neuropsychiatric Genetics & Genomics, Division of Psychological Medicine & Clinical Neurosciences, Cardiff University School of Medicine; Cardiff, CF24 4HQ, UK.; Department of Comparative Medicine, Yale University School of Medicine; New Haven, CT, 06520, USA.; Department of Neuroscience, Yale University School of Medicine; New Haven, CT, 06520, USA.; Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles; Los Angeles, CA, 90095, USA.; Institute for Precision Health, University of California, Los Angeles; Los Angeles, CA, 90095, USA.; Department of Statistics & Data Science, Carnegie Mellon University; Pittsburgh, PA, 15213, USA.; Computational Biology Department, Carnegie Mellon University; Pittsburgh, PA, 15213, USA.; Department of Medical Oncology, Division of Population Sciences, Dana-Farber Cancer Institute; Boston, MA, 02215, USA.; Broad Institute of MIT and Harvard; Cambridge, MA, 02142, USA.; Harvard Medical School; Boston, MA, 02215, USA.; Division of Genetics, Brigham and Women's Hospital; Boston, MA, 02215, USA.; Department of Computational Medicine, David Geffen School of Medicine, University of California, Los Angeles; Los Angeles, CA, 90095, USA.; Department of Biostatistics, University of North Carolina at Chapel Hill; Chapel Hill, NC, 27599, USA.; Department of Epidemiology & Biostatistics, University of California, San Francisco; San Francisco, CA, 94158, USA.; Chan Zuckerberg Biohub; San Francisco, CA, 94158, USA.; Center for Medical Genetics & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University; Changsha, Hunan, 410008, China., Peters MA; CNS Data Coordination Group, Sage Bionetworks; Seattle, WA, 98109, USA., Gerstein M; Department of Molecular Biophysics and Biochemistry, Yale University; New Haven, CT, 06520, USA.; Program in Computational Biology and Bioinformatics, Yale University; New Haven, CT, 06520, USA.; Department of Computer Science, Yale University; New Haven, CT, 06520, USA.; Department of Statistics and Data Science, Yale University; New Haven, CT, 06520, USA., Daskalakis NP; Department of Psychiatry, Harvard Medical School; Boston, MA, 02215, USA.; McLean Hospital; Belmont, MA, 02478, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard; Cambridge, MA, 02142, USA., Weng Z; Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School; Worcester, MA, 01605, USA., Jaffe AE; Lieber Institute for Brain Development; Baltimore, MD, 21205, USA.; Department of Psychiatry & Behavioral Sciences, Johns Hopkins University School of Medicine; Baltimore, MD, 21205, USA.; Department of Neuroscience, Johns Hopkins University School of Medicine; Baltimore, MD, 21205, USA.; Department of Genetic Medicine, Johns Hopkins University School of Medicine; Baltimore, MD, 21205, USA.; Department of Mental Health, Johns Hopkins Bloomberg School of Public Health; Baltimore, MD, 21205, USA.; Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health; Baltimore, MD, 21205, USA.; Neumora Therapeutics; Watertown, MA, 02472, USA., Kleinman JE; Lieber Institute for Brain Development; Baltimore, MD, 21205, USA.; Department of Psychiatry & Behavioral Sciences, Johns Hopkins University School of Medicine; Baltimore, MD, 21205, USA., Hyde TM; Lieber Institute for Brain Development; Baltimore, MD, 21205, USA.; Department of Psychiatry & Behavioral Sciences, Johns Hopkins University School of Medicine; Baltimore, MD, 21205, USA.; Department of Neurology, Johns Hopkins University School of Medicine; Baltimore, MD, 21205, USA., Weinberger DR; Lieber Institute for Brain Development; Baltimore, MD, 21205, USA.; Department of Psychiatry & Behavioral Sciences, Johns Hopkins University School of Medicine; Baltimore, MD, 21205, USA.; Department of Neuroscience, Johns Hopkins University School of Medicine; Baltimore, MD, 21205, USA.; Department of Genetic Medicine, Johns Hopkins University School of Medicine; Baltimore, MD, 21205, USA.; Department of Neurology, Johns Hopkins University School of Medicine; Baltimore, MD, 21205, USA., Bray NJ; MRC Centre for Neuropsychiatric Genetics & Genomics, Division of Psychological Medicine & Clinical Neurosciences, Cardiff University School of Medicine; Cardiff, CF24 4HQ, UK., Sestan N; Department of Comparative Medicine, Yale University School of Medicine; New Haven, CT, 06520, USA.; Department of Neuroscience, Yale University School of Medicine; New Haven, CT, 06520, USA., Geschwind DH; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles; Los Angeles, CA, 90095, USA.; Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles; Los Angeles, CA, 90095, USA.; Institute for Precision Health, University of California, Los Angeles; Los Angeles, CA, 90095, USA., Roeder K; Department of Statistics & Data Science, Carnegie Mellon University; Pittsburgh, PA, 15213, USA.; Computational Biology Department, Carnegie Mellon University; Pittsburgh, PA, 15213, USA., Gusev A; Department of Medical Oncology, Division of Population Sciences, Dana-Farber Cancer Institute; Boston, MA, 02215, USA.; Broad Institute of MIT and Harvard; Cambridge, MA, 02142, USA.; Harvard Medical School; Boston, MA, 02215, USA.; Division of Genetics, Brigham and Women's Hospital; Boston, MA, 02215, USA., Pasaniuc B; Interdepartmental Program in Bioinformatics, University of California, Los Angeles; Los Angeles, CA, 90095, USA.; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles; Los Angeles, CA, 90095, USA.; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles; Los Angeles, CA, 90095, USA.; Institute for Precision Health, University of California, Los Angeles; Los Angeles, CA, 90095, USA.; Department of Computational Medicine, David Geffen School of Medicine, University of California, Los Angeles; Los Angeles, CA, 90095, USA., Stein JL; Department of Genetics, University of North Carolina at Chapel Hill; Chapel Hill, NC, 27599, USA.; UNC Neuroscience Center, University of North Carolina at Chapel Hill; Chapel Hill, NC, 27599, USA., Love MI; Department of Genetics, University of North Carolina at Chapel Hill; Chapel Hill, NC, 27599, USA.; Department of Biostatistics, University of North Carolina at Chapel Hill; Chapel Hill, NC, 27599, USA., Pollard KS; Gladstone Institute of Data Science and Biotechnology; San Francisco, CA, 94158, USA.; Department of Epidemiology & Biostatistics, University of California, San Francisco; San Francisco, CA, 94158, USA.; Chan Zuckerberg Biohub; San Francisco, CA, 94158, USA., Liu C; Department of Psychiatry, SUNY Upstate Medical University; Syracuse, NY, 13210, USA.; Center for Medical Genetics & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University; Changsha, Hunan, 410008, China., Gandal MJ; Interdepartmental Program in Bioinformatics, University of California, Los Angeles; Los Angeles, CA, 90095, USA.; Department of Psychiatry, David Geffen School of Medicine, University of California, Los Angeles; Los Angeles, CA, 90095, USA.; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles; Los Angeles, CA, 90095, USA.; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA, 19104, USA.; Lifespan Brain Institute, The Children's Hospital of Philadelphia; Philadelphia, PA, 19104, USA. |
| Source: | MedRxiv : the preprint server for health sciences [medRxiv] 2023 Mar 06. Date of Electronic Publication: 2023 Mar 06. |
| Publication Type: | Preprint; Journal Article |
| Journal Info: | Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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