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A pan-variant mRNA-LNP T cell vaccine protects HLA transgenic mice from mortality after infection with SARS-CoV-2 Beta.

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Title: A pan-variant mRNA-LNP T cell vaccine protects HLA transgenic mice from mortality after infection with SARS-CoV-2 Beta.
Authors: Carter B; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, United States.; Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, United States., Huang P; Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, TX, United States., Liu G; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, United States.; Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, United States., Liang Y; Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, TX, United States., Lin PJC; Acuitas Therapeutics, Vancouver, BC, Canada., Peng BH; Department of Neuroscience, Cell Biology, and Anatomy, The University of Texas Medical Branch, Galveston, TX, United States., McKay LGA; National Emerging Infectious Diseases Laboratories, Department of Microbiology, Boston University School of Medicine, Boston, MA, United States., Dimitrakakis A; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, United States.; Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, United States., Hsu J; Department of Neuroscience, Cell Biology, and Anatomy, The University of Texas Medical Branch, Galveston, TX, United States., Tat V; Department of Pathology, The University of Texas Medical Branch, Galveston, TX, United States., Saenkham-Huntsinger P; Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, TX, United States., Chen J; Department of Biomedical Engineering, Tufts University, Medford, MA, United States., Kaseke C; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, United States., Gaiha GD; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, United States.; Division of Gastroenterology, Massachusetts General Hospital, Boston, MA, United States., Xu Q; Department of Biomedical Engineering, Tufts University, Medford, MA, United States., Griffiths A; National Emerging Infectious Diseases Laboratories, Department of Microbiology, Boston University School of Medicine, Boston, MA, United States., Tam YK; Acuitas Therapeutics, Vancouver, BC, Canada., Tseng CK; Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, TX, United States.; Department of Neuroscience, Cell Biology, and Anatomy, The University of Texas Medical Branch, Galveston, TX, United States.; Department of Pathology, The University of Texas Medical Branch, Galveston, TX, United States., Gifford DK; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, United States.; Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, United States.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, United States.
Source: Frontiers in immunology [Front Immunol] 2023 Mar 09; Vol. 14, pp. 1135815. Date of Electronic Publication: 2023 Mar 09 (Print Publication: 2023).
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A pan-variant mRNA-LNP T cell vaccine protects HLA transgenic mice from mortality after infection with SARS-CoV-2 Beta.
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  Data: <searchLink fieldCode="AU" term="%22Carter+B%22">Carter B</searchLink>; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, United States.; Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, United States.<br /><searchLink fieldCode="AU" term="%22Huang+P%22">Huang P</searchLink>; Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, TX, United States.<br /><searchLink fieldCode="AU" term="%22Liu+G%22">Liu G</searchLink>; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, United States.; Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, United States.<br /><searchLink fieldCode="AU" term="%22Liang+Y%22">Liang Y</searchLink>; Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, TX, United States.<br /><searchLink fieldCode="AU" term="%22Lin+PJC%22">Lin PJC</searchLink>; Acuitas Therapeutics, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Peng+BH%22">Peng BH</searchLink>; Department of Neuroscience, Cell Biology, and Anatomy, The University of Texas Medical Branch, Galveston, TX, United States.<br /><searchLink fieldCode="AU" term="%22McKay+LGA%22">McKay LGA</searchLink>; National Emerging Infectious Diseases Laboratories, Department of Microbiology, Boston University School of Medicine, Boston, MA, United States.<br /><searchLink fieldCode="AU" term="%22Dimitrakakis+A%22">Dimitrakakis A</searchLink>; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, United States.; Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, United States.<br /><searchLink fieldCode="AU" term="%22Hsu+J%22">Hsu J</searchLink>; Department of Neuroscience, Cell Biology, and Anatomy, The University of Texas Medical Branch, Galveston, TX, United States.<br /><searchLink fieldCode="AU" term="%22Tat+V%22">Tat V</searchLink>; Department of Pathology, The University of Texas Medical Branch, Galveston, TX, United States.<br /><searchLink fieldCode="AU" term="%22Saenkham-Huntsinger+P%22">Saenkham-Huntsinger P</searchLink>; Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, TX, United States.<br /><searchLink fieldCode="AU" term="%22Chen+J%22">Chen J</searchLink>; Department of Biomedical Engineering, Tufts University, Medford, MA, United States.<br /><searchLink fieldCode="AU" term="%22Kaseke+C%22">Kaseke C</searchLink>; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, United States.<br /><searchLink fieldCode="AU" term="%22Gaiha+GD%22">Gaiha GD</searchLink>; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, United States.; Division of Gastroenterology, Massachusetts General Hospital, Boston, MA, United States.<br /><searchLink fieldCode="AU" term="%22Xu+Q%22">Xu Q</searchLink>; Department of Biomedical Engineering, Tufts University, Medford, MA, United States.<br /><searchLink fieldCode="AU" term="%22Griffiths+A%22">Griffiths A</searchLink>; National Emerging Infectious Diseases Laboratories, Department of Microbiology, Boston University School of Medicine, Boston, MA, United States.<br /><searchLink fieldCode="AU" term="%22Tam+YK%22">Tam YK</searchLink>; Acuitas Therapeutics, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Tseng+CK%22">Tseng CK</searchLink>; Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, TX, United States.; Department of Neuroscience, Cell Biology, and Anatomy, The University of Texas Medical Branch, Galveston, TX, United States.; Department of Pathology, The University of Texas Medical Branch, Galveston, TX, United States.<br /><searchLink fieldCode="AU" term="%22Gifford+DK%22">Gifford DK</searchLink>; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, United States.; Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, United States.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, United States.
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  Data: <searchLink fieldCode="JN" term="%22101560960%22">Frontiers in immunology</searchLink> [Front Immunol] 2023 Mar 09; Vol. 14, pp. 1135815. <i>Date of Electronic Publication: </i>2023 Mar 09 (<i>Print Publication: </i>2023).
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        Value: 10.3389/fimmu.2023.1135815
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