BRCA1 secondary splice-site mutations drive exon-skipping and PARP inhibitor resistance.
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| Title: | BRCA1 secondary splice-site mutations drive exon-skipping and PARP inhibitor resistance. |
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| Authors: | Nesic K; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia., Krais JJ; Fox Chase Cancer Center, PA, USA., Vandenberg CJ; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia., Wang Y; Fox Chase Cancer Center, PA, USA., Patel P; Fox Chase Cancer Center, PA, USA., Cai KQ; Fox Chase Cancer Center, PA, USA., Kwan T; Clovis Oncology Inc., San Francisco, CA, USA., Lieschke E; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia., Ho GY; School of Clinical Sciences, Monash University, Clayton, Victoria, Australia., Barker HE; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia., Bedo J; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia., Casadei S; University of Washington, Seattle, WA, USA., Farrell A; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia., Radke M; University of Washington, Seattle, WA, USA., Shield-Artin K; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia., Penington JS; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia., Geissler F; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia., Kyran E; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia., Zhang F; University of Melbourne Department of Surgery, Austin Health, Heidelberg, Victoria, Australia., Dobrovic A; University of Melbourne Department of Surgery, Austin Health, Heidelberg, Victoria, Australia., Olesen I; The Andrew Love Cancer Centre, Barwon Health, Geelong, Victoria, Australia., Kristeleit R; Department of Oncology, Guys and St Thomas' NHS Foundation Trust, London, UK.; National Institute for Health Research, University College London Hospitals Clinical Research Facility, London, UK., Oza A; Princess Margaret Cancer Center, Toronto, ON, Canada., Ratnayake G; Royal Women's Hospital, Parkville, VIC, Australia., Traficante N; Sir Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC, Australia., DeFazio A; The Daffodil Centre, The University of Sydney, a joint venture with Cancer Council New South Wales, Sydney, New South Wales, Australia.; The Westmead Institute for Medical Research, Sydney, New South Wales, Australia.; Department of Gynecological Oncology, Westmead Hospital, Western Sydney Local Health District, New South Wales, Australia., Bowtell DDL; Sir Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC, Australia., Harding TC; Clovis Oncology Inc., San Francisco, CA, USA., Lin K; Clovis Oncology Inc., San Francisco, CA, USA., Swisher EM; University of Washington, Seattle, WA, USA., Kondrashova O; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., Scott CL; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia.; Royal Women's Hospital, Parkville, VIC, Australia.; Sir Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC, Australia.; Department of Obstetrics and Gynecology, University of Melbourne, Parkville, VIC, Australia., Johnson N; Fox Chase Cancer Center, PA, USA., Wakefield MJ; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia.; Department of Obstetrics and Gynecology, University of Melbourne, Parkville, VIC, Australia. |
| Corporate Authors: | Australian Ovarian Cancer Study |
| Source: | MedRxiv : the preprint server for health sciences [medRxiv] 2023 Aug 28. Date of Electronic Publication: 2023 Aug 28. |
| Publication Type: | Preprint; Journal Article |
| Journal Info: | Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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