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Molecular characterisation defines clinically-actionable heterogeneity within Group 4 medulloblastoma and improves disease risk-stratification.

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Title: Molecular characterisation defines clinically-actionable heterogeneity within Group 4 medulloblastoma and improves disease risk-stratification.
Authors: Goddard J; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Newcastle Upon Tyne, UK., Castle J; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Newcastle Upon Tyne, UK., Southworth E; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Newcastle Upon Tyne, UK., Fletcher A; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Newcastle Upon Tyne, UK., Crosier S; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Newcastle Upon Tyne, UK., Martin-Guerrero I; Biocruces Bizkaia Health Research Institute, Barakaldo, Spain.; Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country, Leioa, Spain., García-Ariza M; Biocruces Bizkaia Health Research Institute, Barakaldo, Spain.; Department of Pediatric Hematology and Oncology, Cruces University Hospital, Barakaldo, Spain., Navajas A; Biocruces Bizkaia Health Research Institute, Barakaldo, Spain., Masliah-Planchon J; Unité de Génétique Somatique, Institut Curie, Paris, France., Bourdeaut F; SIREDO Pediatric Oncology Center, Curie Institute, Paris, France., Dufour C; Department of Pediatric and Adolescent Oncology, Gustave Roussy, Rue Edouard Vaillant, 94805, Villejuif, France., Ayrault O; UMR 3347, INSERM U1021, Institut Curie, PSL Research University, Université Paris Sud, Université Paris-Saclay, CNRS, Paris, France., Goschzik T; Department of Neuropathology, DGNN Brain Tumour Reference Center, University of Bonn Medical Center, Bonn, Germany., Pietsch T; Department of Neuropathology, DGNN Brain Tumour Reference Center, University of Bonn Medical Center, Bonn, Germany., Sill M; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of Paediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany., Pfister SM; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of Paediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.; Department of Paediatric Haematology and Oncology, Heidelberg University Hospital, Heidelberg, Germany., Rutkowski S; Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Richardson S; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Newcastle Upon Tyne, UK., Hill RM; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Newcastle Upon Tyne, UK., Williamson D; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Newcastle Upon Tyne, UK., Bailey S; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Newcastle Upon Tyne, UK., Schwalbe EC; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Newcastle Upon Tyne, UK.; Department of Applied Sciences, Northumbria University, Newcastle Upon Tyne, UK., Clifford SC; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Newcastle Upon Tyne, UK. steve.clifford@ncl.ac.uk., Hicks D; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Newcastle Upon Tyne, UK. debbie.hicks@newcastle.ac.uk.
Source: Acta neuropathologica [Acta Neuropathol] 2023 May; Vol. 145 (5), pp. 651-666. Date of Electronic Publication: 2023 Apr 04.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0412041 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0533 (Electronic) Linking ISSN: 00016322 NLM ISO Abbreviation: Acta Neuropathol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Molecular characterisation defines clinically-actionable heterogeneity within Group 4 medulloblastoma and improves disease risk-stratification.
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  Data: <searchLink fieldCode="AU" term="%22Goddard+J%22">Goddard J</searchLink>; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Newcastle Upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Castle+J%22">Castle J</searchLink>; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Newcastle Upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Southworth+E%22">Southworth E</searchLink>; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Newcastle Upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Fletcher+A%22">Fletcher A</searchLink>; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Newcastle Upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Crosier+S%22">Crosier S</searchLink>; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Newcastle Upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Martin-Guerrero+I%22">Martin-Guerrero I</searchLink>; Biocruces Bizkaia Health Research Institute, Barakaldo, Spain.; Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country, Leioa, Spain.<br /><searchLink fieldCode="AU" term="%22García-Ariza+M%22">García-Ariza M</searchLink>; Biocruces Bizkaia Health Research Institute, Barakaldo, Spain.; Department of Pediatric Hematology and Oncology, Cruces University Hospital, Barakaldo, Spain.<br /><searchLink fieldCode="AU" term="%22Navajas+A%22">Navajas A</searchLink>; Biocruces Bizkaia Health Research Institute, Barakaldo, Spain.<br /><searchLink fieldCode="AU" term="%22Masliah-Planchon+J%22">Masliah-Planchon J</searchLink>; Unité de Génétique Somatique, Institut Curie, Paris, France.<br /><searchLink fieldCode="AU" term="%22Bourdeaut+F%22">Bourdeaut F</searchLink>; SIREDO Pediatric Oncology Center, Curie Institute, Paris, France.<br /><searchLink fieldCode="AU" term="%22Dufour+C%22">Dufour C</searchLink>; Department of Pediatric and Adolescent Oncology, Gustave Roussy, Rue Edouard Vaillant, 94805, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Ayrault+O%22">Ayrault O</searchLink>; UMR 3347, INSERM U1021, Institut Curie, PSL Research University, Université Paris Sud, Université Paris-Saclay, CNRS, Paris, France.<br /><searchLink fieldCode="AU" term="%22Goschzik+T%22">Goschzik T</searchLink>; Department of Neuropathology, DGNN Brain Tumour Reference Center, University of Bonn Medical Center, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Pietsch+T%22">Pietsch T</searchLink>; Department of Neuropathology, DGNN Brain Tumour Reference Center, University of Bonn Medical Center, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Sill+M%22">Sill M</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of Paediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Pfister+SM%22">Pfister SM</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of Paediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.; Department of Paediatric Haematology and Oncology, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Rutkowski+S%22">Rutkowski S</searchLink>; Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Richardson+S%22">Richardson S</searchLink>; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Newcastle Upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Hill+RM%22">Hill RM</searchLink>; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Newcastle Upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Williamson+D%22">Williamson D</searchLink>; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Newcastle Upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Bailey+S%22">Bailey S</searchLink>; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Newcastle Upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Schwalbe+EC%22">Schwalbe EC</searchLink>; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Newcastle Upon Tyne, UK.; Department of Applied Sciences, Northumbria University, Newcastle Upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Clifford+SC%22">Clifford SC</searchLink>; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Newcastle Upon Tyne, UK. steve.clifford@ncl.ac.uk.<br /><searchLink fieldCode="AU" term="%22Hicks+D%22">Hicks D</searchLink>; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Newcastle Upon Tyne, UK. debbie.hicks@newcastle.ac.uk.
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  Data: <searchLink fieldCode="JN" term="%220412041%22">Acta neuropathologica</searchLink> [Acta Neuropathol] 2023 May; Vol. 145 (5), pp. 651-666. <i>Date of Electronic Publication: </i>2023 Apr 04.
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