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Glucocerebrosidase is imported into mitochondria and preserves complex I integrity and energy metabolism.

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Title: Glucocerebrosidase is imported into mitochondria and preserves complex I integrity and energy metabolism.
Authors: Baden P; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.; Department of Neurodegenerative Diseases, Center of Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA., Perez MJ; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.; Department of Neurodegenerative Diseases, Center of Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA., Raji H; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.; Department of Neurodegenerative Diseases, Center of Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA., Bertoli F; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.; Department of Neurodegenerative Diseases, Center of Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA., Kalb S; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.; Department of Neurodegenerative Diseases, Center of Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany., Illescas M; Instituto de Investigación Hospital 12 de Octubre (i + 12), Madrid, 28041, Spain., Spanos F; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.; Department of Neurodegenerative Diseases, Center of Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA., Giuliano C; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.; Department of Neurodegenerative Diseases, Center of Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.; Unit of Cellular and Molecular Neurobiology, IRCCS Mondino Foundation, 27100, Pavia, Italy., Calogero AM; Department of Biosciences, Center of Excellence on Neurodegenerative Diseases, Università degli Studi di Milano, Milan, Italy., Oldrati M; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.; Department of Neurodegenerative Diseases, Center of Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA., Hebestreit H; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.; Department of Neurodegenerative Diseases, Center of Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany., Cappelletti G; Department of Biosciences, Center of Excellence on Neurodegenerative Diseases, Università degli Studi di Milano, Milan, Italy., Brockmann K; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.; Department of Neurodegenerative Diseases, Center of Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany., Gasser T; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.; Department of Neurodegenerative Diseases, Center of Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany., Schapira AHV; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA.; Department of Clinical and Movement Neurosciences, University College London Queen Square Institute of Neurology, Royal Free Campus, London, NW3 2PF, UK., Ugalde C; Instituto de Investigación Hospital 12 de Octubre (i + 12), Madrid, 28041, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), U723, Madrid, Spain., Deleidi M; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany. michela.deleidi@institutimagine.org.; Department of Neurodegenerative Diseases, Center of Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany. michela.deleidi@institutimagine.org.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA. michela.deleidi@institutimagine.org.; Institut Imagine, INSERM UMR1163 Paris Cite' University, 24 boulevard du Montparnasse, 75015, Paris, France. michela.deleidi@institutimagine.org.
Source: Nature communications [Nat Commun] 2023 Apr 06; Vol. 14 (1), pp. 1930. Date of Electronic Publication: 2023 Apr 06.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Glucocerebrosidase is imported into mitochondria and preserves complex I integrity and energy metabolism.
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  Data: <searchLink fieldCode="AU" term="%22Baden+P%22">Baden P</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.; Department of Neurodegenerative Diseases, Center of Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA.<br /><searchLink fieldCode="AU" term="%22Perez+MJ%22">Perez MJ</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.; Department of Neurodegenerative Diseases, Center of Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA.<br /><searchLink fieldCode="AU" term="%22Raji+H%22">Raji H</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.; Department of Neurodegenerative Diseases, Center of Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA.<br /><searchLink fieldCode="AU" term="%22Bertoli+F%22">Bertoli F</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.; Department of Neurodegenerative Diseases, Center of Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA.<br /><searchLink fieldCode="AU" term="%22Kalb+S%22">Kalb S</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.; Department of Neurodegenerative Diseases, Center of Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Illescas+M%22">Illescas M</searchLink>; Instituto de Investigación Hospital 12 de Octubre (i + 12), Madrid, 28041, Spain.<br /><searchLink fieldCode="AU" term="%22Spanos+F%22">Spanos F</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.; Department of Neurodegenerative Diseases, Center of Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA.<br /><searchLink fieldCode="AU" term="%22Giuliano+C%22">Giuliano C</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.; Department of Neurodegenerative Diseases, Center of Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.; Unit of Cellular and Molecular Neurobiology, IRCCS Mondino Foundation, 27100, Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Calogero+AM%22">Calogero AM</searchLink>; Department of Biosciences, Center of Excellence on Neurodegenerative Diseases, Università degli Studi di Milano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Oldrati+M%22">Oldrati M</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.; Department of Neurodegenerative Diseases, Center of Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA.<br /><searchLink fieldCode="AU" term="%22Hebestreit+H%22">Hebestreit H</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.; Department of Neurodegenerative Diseases, Center of Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Cappelletti+G%22">Cappelletti G</searchLink>; Department of Biosciences, Center of Excellence on Neurodegenerative Diseases, Università degli Studi di Milano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Brockmann+K%22">Brockmann K</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.; Department of Neurodegenerative Diseases, Center of Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Gasser+T%22">Gasser T</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.; Department of Neurodegenerative Diseases, Center of Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Schapira+AHV%22">Schapira AHV</searchLink>; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA.; Department of Clinical and Movement Neurosciences, University College London Queen Square Institute of Neurology, Royal Free Campus, London, NW3 2PF, UK.<br /><searchLink fieldCode="AU" term="%22Ugalde+C%22">Ugalde C</searchLink>; Instituto de Investigación Hospital 12 de Octubre (i + 12), Madrid, 28041, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), U723, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Deleidi+M%22">Deleidi M</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany. michela.deleidi@institutimagine.org.; Department of Neurodegenerative Diseases, Center of Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany. michela.deleidi@institutimagine.org.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA. michela.deleidi@institutimagine.org.; Institut Imagine, INSERM UMR1163 Paris Cite' University, 24 boulevard du Montparnasse, 75015, Paris, France. michela.deleidi@institutimagine.org.
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