Persistence of immune response in heterologous COVID vaccination schedules in the Com-COV2 study - A single-blind, randomised trial incorporating mRNA, viral-vector and protein-adjuvant vaccines.

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Title: Persistence of immune response in heterologous COVID vaccination schedules in the Com-COV2 study - A single-blind, randomised trial incorporating mRNA, viral-vector and protein-adjuvant vaccines.
Authors: Shaw RH; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK; Oxford University Hospitals NHS Foundation Trust, Oxford, UK. Electronic address: robert.shaw@paediatrics.ox.ac.uk., Greenland M; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Stuart ASV; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK; Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Aley PK; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Andrews NJ; Immunisation and Vaccine Preventable Diseases Division, UK Health Security Agency, London, UK., Cameron JC; Public Health Scotland, Glasgow, Scotland, UK., Charlton S; UK Health Security Agency, Porton Down, Salisbury, UK., Clutterbuck EA; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Collins AM; Liverpool School of Tropical Medicine, Liverpool, UK., Darton T; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, UK; Department of Infection and Tropical Medicine, Sheffield Teaching Hospitals NHS Foundation Trust, UK., Dinesh T; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Duncan CJA; The Newcastle upon Tyne Hospitals NHS Foundation Trust, UK; Translational and Clinical Research Institute, Newcastle University, UK., Faust SN; NIHR Southampton Clinical Research Facility and Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK; Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK., Ferreira DM; Liverpool School of Tropical Medicine, Liverpool, UK., Finn A; Schools of Population Health Sciences and Cellular and Molecular Medicine, University of Bristol, Bristol, UK., Goodman AL; Department of Infection & NIHR BRC, Guy's and St Thomas' NHS Foundation Trust, UK; MRC Clinical Trials Unit, University College London, UK., Green CA; NIHR/Wellcome Trust Clinical Research Facility, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK; School of Chemical Engineering, University of Birmingham, UK., Hallis B; UK Health Security Agency, Porton Down, Salisbury, UK., Heath PT; The Vaccine Institute, St. George's University of London, London, UK., Hill H; Liverpool School of Tropical Medicine, Liverpool, UK., Lambe T; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK., Libri V; NIHR UCLH Clinical Research Facility and NIHR UCLH Biomedical Research Centre, University College London Hospitals NHS Foundation Trust, London, UK., Lillie PJ; Infection Research Group, Hull University Teaching Hospitals NHS Trust, Hull, UK., Morey E; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Mujadidi YF; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Payne R; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, UK; Department of Infection and Tropical Medicine, Sheffield Teaching Hospitals NHS Foundation Trust, UK., Plested EL; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Provstgaard-Morys S; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Ramasamy MN; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK; Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Ramsay M; Immunisation and Vaccine Preventable Diseases Division, UK Health Security Agency, London, UK., Read RC; NIHR Southampton Clinical Research Facility and Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK; Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK., Robinson H; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Screaton GR; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Singh N; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Turner DPJ; University of Nottingham, Nottingham, UK; Nottingham University Hospitals NHS Trust, Nottingham, UK., Turner PJ; National Heart & Lung Institute, Imperial College London, London, UK., White R; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Nguyen-Van-Tam JS; Unit of Lifespan and Population Health, University of Nottingham School of Medicine, Nottingham, UK., Liu X; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Snape MD; Oxford NIHR - Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
Corporate Authors: Com-COV2 Study Group
Source: The Journal of infection [J Infect] 2023 Jun; Vol. 86 (6), pp. 574-583. Date of Electronic Publication: 2023 Apr 06.
Publication Type: Randomized Controlled Trial; Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: W.B. Saunders Country of Publication: England NLM ID: 7908424 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2742 (Electronic) Linking ISSN: 01634453 NLM ISO Abbreviation: J Infect Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Persistence of immune response in heterologous COVID vaccination schedules in the Com-COV2 study - A single-blind, randomised trial incorporating mRNA, viral-vector and protein-adjuvant vaccines.
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  Data: <searchLink fieldCode="AU" term="%22Shaw+RH%22">Shaw RH</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK; Oxford University Hospitals NHS Foundation Trust, Oxford, UK. Electronic address: robert.shaw@paediatrics.ox.ac.uk.<br /><searchLink fieldCode="AU" term="%22Greenland+M%22">Greenland M</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Stuart+ASV%22">Stuart ASV</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK; Oxford University Hospitals NHS Foundation Trust, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Aley+PK%22">Aley PK</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Andrews+NJ%22">Andrews NJ</searchLink>; Immunisation and Vaccine Preventable Diseases Division, UK Health Security Agency, London, UK.<br /><searchLink fieldCode="AU" term="%22Cameron+JC%22">Cameron JC</searchLink>; Public Health Scotland, Glasgow, Scotland, UK.<br /><searchLink fieldCode="AU" term="%22Charlton+S%22">Charlton S</searchLink>; UK Health Security Agency, Porton Down, Salisbury, UK.<br /><searchLink fieldCode="AU" term="%22Clutterbuck+EA%22">Clutterbuck EA</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Collins+AM%22">Collins AM</searchLink>; Liverpool School of Tropical Medicine, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Darton+T%22">Darton T</searchLink>; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, UK; Department of Infection and Tropical Medicine, Sheffield Teaching Hospitals NHS Foundation Trust, UK.<br /><searchLink fieldCode="AU" term="%22Dinesh+T%22">Dinesh T</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Duncan+CJA%22">Duncan CJA</searchLink>; The Newcastle upon Tyne Hospitals NHS Foundation Trust, UK; Translational and Clinical Research Institute, Newcastle University, UK.<br /><searchLink fieldCode="AU" term="%22Faust+SN%22">Faust SN</searchLink>; NIHR Southampton Clinical Research Facility and Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK; Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK.<br /><searchLink fieldCode="AU" term="%22Ferreira+DM%22">Ferreira DM</searchLink>; Liverpool School of Tropical Medicine, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Finn+A%22">Finn A</searchLink>; Schools of Population Health Sciences and Cellular and Molecular Medicine, University of Bristol, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Goodman+AL%22">Goodman AL</searchLink>; Department of Infection & NIHR BRC, Guy's and St Thomas' NHS Foundation Trust, UK; MRC Clinical Trials Unit, University College London, UK.<br /><searchLink fieldCode="AU" term="%22Green+CA%22">Green CA</searchLink>; NIHR/Wellcome Trust Clinical Research Facility, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK; School of Chemical Engineering, University of Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Hallis+B%22">Hallis B</searchLink>; UK Health Security Agency, Porton Down, Salisbury, UK.<br /><searchLink fieldCode="AU" term="%22Heath+PT%22">Heath PT</searchLink>; The Vaccine Institute, St. George's University of London, London, UK.<br /><searchLink fieldCode="AU" term="%22Hill+H%22">Hill H</searchLink>; Liverpool School of Tropical Medicine, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Lambe+T%22">Lambe T</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Libri+V%22">Libri V</searchLink>; NIHR UCLH Clinical Research Facility and NIHR UCLH Biomedical Research Centre, University College London Hospitals NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Lillie+PJ%22">Lillie PJ</searchLink>; Infection Research Group, Hull University Teaching Hospitals NHS Trust, Hull, UK.<br /><searchLink fieldCode="AU" term="%22Morey+E%22">Morey E</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Mujadidi+YF%22">Mujadidi YF</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Payne+R%22">Payne R</searchLink>; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, UK; Department of Infection and Tropical Medicine, Sheffield Teaching Hospitals NHS Foundation Trust, UK.<br /><searchLink fieldCode="AU" term="%22Plested+EL%22">Plested EL</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Provstgaard-Morys+S%22">Provstgaard-Morys S</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Ramasamy+MN%22">Ramasamy MN</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK; Oxford University Hospitals NHS Foundation Trust, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Ramsay+M%22">Ramsay M</searchLink>; Immunisation and Vaccine Preventable Diseases Division, UK Health Security Agency, London, UK.<br /><searchLink fieldCode="AU" term="%22Read+RC%22">Read RC</searchLink>; NIHR Southampton Clinical Research Facility and Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK; Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK.<br /><searchLink fieldCode="AU" term="%22Robinson+H%22">Robinson H</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Screaton+GR%22">Screaton GR</searchLink>; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Singh+N%22">Singh N</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Turner+DPJ%22">Turner DPJ</searchLink>; University of Nottingham, Nottingham, UK; Nottingham University Hospitals NHS Trust, Nottingham, UK.<br /><searchLink fieldCode="AU" term="%22Turner+PJ%22">Turner PJ</searchLink>; National Heart & Lung Institute, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22White+R%22">White R</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Nguyen-Van-Tam+JS%22">Nguyen-Van-Tam JS</searchLink>; Unit of Lifespan and Population Health, University of Nottingham School of Medicine, Nottingham, UK.<br /><searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Snape+MD%22">Snape MD</searchLink>; Oxford NIHR - Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
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