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PI3K Inhibition Restores and Amplifies Response to Ruxolitinib in Patients with Myelofibrosis.

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Title: PI3K Inhibition Restores and Amplifies Response to Ruxolitinib in Patients with Myelofibrosis.
Authors: Moyo TK; Department of Internal Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.; Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee.; Levine Cancer Institute, Charlotte, North Carolina., Kishtagari A; Department of Internal Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.; Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee., Villaume MT; Department of Internal Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee., McMahon B; University of Colorado, Denver, Colorado., Mohan SR; Department of Internal Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.; Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee., Stopczynski T; Department of Internal Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.; Center for Quantitative Sciences, Vanderbilt University, Nashville, Tennessee., Chen SC; Department of Internal Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.; Center for Quantitative Sciences, Vanderbilt University, Nashville, Tennessee., Fan R; Department of Internal Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.; Center for Quantitative Sciences, Vanderbilt University, Nashville, Tennessee., Huo Y; Department of Electrical and Computer Engineering, Vanderbilt University School of Medicine, Nashville, Tennessee., Moon H; Department of Electrical and Computer Engineering, Vanderbilt University School of Medicine, Nashville, Tennessee., Tang Y; Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, Tennessee., Bejan CA; Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, Tennessee., Childress M; Department of Internal Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee., Anderson I; Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee., Rawling K; Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee., Simons RM; Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee., Moncrief A; Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee., Caza R; Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee., Dugger L; Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee., Collins A; Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee., Dudley CV; Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee., Ferrell PB; Department of Internal Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.; Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee.; Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee.; Center for Immunobiology, Vanderbilt University School of Medicine, Nashville, Tennessee., Byrne M; Department of Internal Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.; Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee., Strickland SA; Department of Internal Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.; Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee., Ayers GD; Department of Internal Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.; Center for Quantitative Sciences, Vanderbilt University, Nashville, Tennessee., Landman BA; Department of Electrical and Computer Engineering, Vanderbilt University School of Medicine, Nashville, Tennessee.; Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, Tennessee., Mason EF; Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee., Mesa RA; Wake Forest Baptist Cancer Center, Winston-Salem, North Carolina., Palmer JM; Department of Internal Medicine, Mayo Clinic, Scottsdale, Arizona., Michaelis LC; Medical College of Wisconsin, Madison, Wisconsin., Savona MR; Department of Internal Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.; Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee.; Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee.; Center for Immunobiology, Vanderbilt University School of Medicine, Nashville, Tennessee.
Source: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2023 Jul 05; Vol. 29 (13), pp. 2375-2384.
Publication Type: Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 9502500 Publication Model: Print Cited Medium: Internet ISSN: 1557-3265 (Electronic) Linking ISSN: 10780432 NLM ISO Abbreviation: Clin Cancer Res Subsets: MEDLINE
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  Data: PI3K Inhibition Restores and Amplifies Response to Ruxolitinib in Patients with Myelofibrosis.
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  Data: <searchLink fieldCode="AU" term="%22Moyo+TK%22">Moyo TK</searchLink>; Department of Internal Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.; Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee.; Levine Cancer Institute, Charlotte, North Carolina.<br /><searchLink fieldCode="AU" term="%22Kishtagari+A%22">Kishtagari A</searchLink>; Department of Internal Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.; Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee.<br /><searchLink fieldCode="AU" term="%22Villaume+MT%22">Villaume MT</searchLink>; Department of Internal Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.<br /><searchLink fieldCode="AU" term="%22McMahon+B%22">McMahon B</searchLink>; University of Colorado, Denver, Colorado.<br /><searchLink fieldCode="AU" term="%22Mohan+SR%22">Mohan SR</searchLink>; Department of Internal Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.; Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee.<br /><searchLink fieldCode="AU" term="%22Stopczynski+T%22">Stopczynski T</searchLink>; Department of Internal Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.; Center for Quantitative Sciences, Vanderbilt University, Nashville, Tennessee.<br /><searchLink fieldCode="AU" term="%22Chen+SC%22">Chen SC</searchLink>; Department of Internal Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.; Center for Quantitative Sciences, Vanderbilt University, Nashville, Tennessee.<br /><searchLink fieldCode="AU" term="%22Fan+R%22">Fan R</searchLink>; Department of Internal Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.; Center for Quantitative Sciences, Vanderbilt University, Nashville, Tennessee.<br /><searchLink fieldCode="AU" term="%22Huo+Y%22">Huo Y</searchLink>; Department of Electrical and Computer Engineering, Vanderbilt University School of Medicine, Nashville, Tennessee.<br /><searchLink fieldCode="AU" term="%22Moon+H%22">Moon H</searchLink>; Department of Electrical and Computer Engineering, Vanderbilt University School of Medicine, Nashville, Tennessee.<br /><searchLink fieldCode="AU" term="%22Tang+Y%22">Tang Y</searchLink>; Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, Tennessee.<br /><searchLink fieldCode="AU" term="%22Bejan+CA%22">Bejan CA</searchLink>; Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, Tennessee.<br /><searchLink fieldCode="AU" term="%22Childress+M%22">Childress M</searchLink>; Department of Internal Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.<br /><searchLink fieldCode="AU" term="%22Anderson+I%22">Anderson I</searchLink>; Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee.<br /><searchLink fieldCode="AU" term="%22Rawling+K%22">Rawling K</searchLink>; Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee.<br /><searchLink fieldCode="AU" term="%22Simons+RM%22">Simons RM</searchLink>; Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee.<br /><searchLink fieldCode="AU" term="%22Moncrief+A%22">Moncrief A</searchLink>; Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee.<br /><searchLink fieldCode="AU" term="%22Caza+R%22">Caza R</searchLink>; Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee.<br /><searchLink fieldCode="AU" term="%22Dugger+L%22">Dugger L</searchLink>; Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee.<br /><searchLink fieldCode="AU" term="%22Collins+A%22">Collins A</searchLink>; Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee.<br /><searchLink fieldCode="AU" term="%22Dudley+CV%22">Dudley CV</searchLink>; Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee.<br /><searchLink fieldCode="AU" term="%22Ferrell+PB%22">Ferrell PB</searchLink>; Department of Internal Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.; Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee.; Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee.; Center for Immunobiology, Vanderbilt University School of Medicine, Nashville, Tennessee.<br /><searchLink fieldCode="AU" term="%22Byrne+M%22">Byrne M</searchLink>; Department of Internal Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.; Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee.<br /><searchLink fieldCode="AU" term="%22Strickland+SA%22">Strickland SA</searchLink>; Department of Internal Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.; Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee.<br /><searchLink fieldCode="AU" term="%22Ayers+GD%22">Ayers GD</searchLink>; Department of Internal Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.; Center for Quantitative Sciences, Vanderbilt University, Nashville, Tennessee.<br /><searchLink fieldCode="AU" term="%22Landman+BA%22">Landman BA</searchLink>; Department of Electrical and Computer Engineering, Vanderbilt University School of Medicine, Nashville, Tennessee.; Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, Tennessee.<br /><searchLink fieldCode="AU" term="%22Mason+EF%22">Mason EF</searchLink>; Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee.<br /><searchLink fieldCode="AU" term="%22Mesa+RA%22">Mesa RA</searchLink>; Wake Forest Baptist Cancer Center, Winston-Salem, North Carolina.<br /><searchLink fieldCode="AU" term="%22Palmer+JM%22">Palmer JM</searchLink>; Department of Internal Medicine, Mayo Clinic, Scottsdale, Arizona.<br /><searchLink fieldCode="AU" term="%22Michaelis+LC%22">Michaelis LC</searchLink>; Medical College of Wisconsin, Madison, Wisconsin.<br /><searchLink fieldCode="AU" term="%22Savona+MR%22">Savona MR</searchLink>; Department of Internal Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.; Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee.; Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee.; Center for Immunobiology, Vanderbilt University School of Medicine, Nashville, Tennessee.
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  Data: <searchLink fieldCode="JN" term="%229502500%22">Clinical cancer research : an official journal of the American Association for Cancer Research</searchLink> [Clin Cancer Res] 2023 Jul 05; Vol. 29 (13), pp. 2375-2384.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+Cancer+Research%22">American Association for Cancer Research </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9502500 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1557-3265 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210780432%22">10780432 </searchLink><i>NLM ISO Abbreviation: </i>Clin Cancer Res <i>Subsets: </i>MEDLINE
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        Value: 10.1158/1078-0432.CCR-22-3192
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