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Effects of Genetic Polymorphisms of Drug Metabolizing Enzymes and co-Medications on Tamoxifen Metabolism in Black South African Women with Breast Cancer.

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Title: Effects of Genetic Polymorphisms of Drug Metabolizing Enzymes and co-Medications on Tamoxifen Metabolism in Black South African Women with Breast Cancer.
Authors: Chiwambutsa SM; Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; Division of Human Genetics, National Health Laboratory Service, and School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Ayeni O; Strengthening Oncology Services Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; Department of Radiation Oncology, Department of Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Kapungu N; African Institute of Biomedical Science and Technology (AiBST), Harare, Zimbabwe., Kanji C; African Institute of Biomedical Science and Technology (AiBST), Harare, Zimbabwe., Thelingwani R; African Institute of Biomedical Science and Technology (AiBST), Harare, Zimbabwe., Chen WC; Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; Strengthening Oncology Services Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; National Cancer Registry, National Health Laboratory Service, Johannesburg, South Africa., Mokone DH; Department of Surgery, Sefako Makgatho Health Sciences University, Dr George Mukhari Academic Hospital, Ga-Rankuwa, South Africa., O'Neil DS; Comprehensive Cancer Center and Department of Medicine, Miller School of Medicine, University of Miami, Miami, Florida, USA., Neugut AI; Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.; Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA., Jacobson JS; Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA., Ruff P; Strengthening Oncology Services Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; South Africa Medical Research Council Common Epithelial Cancers Research Center, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; Division of Medical Oncology, University of the Witwatersrand, Johannesburg, South Africa., Cubasch H; Strengthening Oncology Services Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; South Africa Medical Research Council Common Epithelial Cancers Research Center, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; Department of Surgery, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Joffe M; Strengthening Oncology Services Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; South Africa Medical Research Council Common Epithelial Cancers Research Center, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; SAMRC/Wits Developmental Pathways to Health Research Unit, Department of Pediatrics, Faculty of Health Sciences, University of the Witwatersrand Johannesburg, Johannesburg, South Africa., Masimirembwa C; Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; Department of Surgery, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Source: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2023 Jul; Vol. 114 (1), pp. 127-136. Date of Electronic Publication: 2023 Apr 28.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: Wiley Country of Publication: United States NLM ID: 0372741 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-6535 (Electronic) Linking ISSN: 00099236 NLM ISO Abbreviation: Clin Pharmacol Ther Subsets: MEDLINE
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  Data: Effects of Genetic Polymorphisms of Drug Metabolizing Enzymes and co-Medications on Tamoxifen Metabolism in Black South African Women with Breast Cancer.
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  Data: <searchLink fieldCode="AU" term="%22Chiwambutsa+SM%22">Chiwambutsa SM</searchLink>; Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; Division of Human Genetics, National Health Laboratory Service, and School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.<br /><searchLink fieldCode="AU" term="%22Ayeni+O%22">Ayeni O</searchLink>; Strengthening Oncology Services Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; Department of Radiation Oncology, Department of Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.<br /><searchLink fieldCode="AU" term="%22Kapungu+N%22">Kapungu N</searchLink>; African Institute of Biomedical Science and Technology (AiBST), Harare, Zimbabwe.<br /><searchLink fieldCode="AU" term="%22Kanji+C%22">Kanji C</searchLink>; African Institute of Biomedical Science and Technology (AiBST), Harare, Zimbabwe.<br /><searchLink fieldCode="AU" term="%22Thelingwani+R%22">Thelingwani R</searchLink>; African Institute of Biomedical Science and Technology (AiBST), Harare, Zimbabwe.<br /><searchLink fieldCode="AU" term="%22Chen+WC%22">Chen WC</searchLink>; Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; Strengthening Oncology Services Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; National Cancer Registry, National Health Laboratory Service, Johannesburg, South Africa.<br /><searchLink fieldCode="AU" term="%22Mokone+DH%22">Mokone DH</searchLink>; Department of Surgery, Sefako Makgatho Health Sciences University, Dr George Mukhari Academic Hospital, Ga-Rankuwa, South Africa.<br /><searchLink fieldCode="AU" term="%22O'Neil+DS%22">O'Neil DS</searchLink>; Comprehensive Cancer Center and Department of Medicine, Miller School of Medicine, University of Miami, Miami, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Neugut+AI%22">Neugut AI</searchLink>; Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.; Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Jacobson+JS%22">Jacobson JS</searchLink>; Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Ruff+P%22">Ruff P</searchLink>; Strengthening Oncology Services Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; South Africa Medical Research Council Common Epithelial Cancers Research Center, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; Division of Medical Oncology, University of the Witwatersrand, Johannesburg, South Africa.<br /><searchLink fieldCode="AU" term="%22Cubasch+H%22">Cubasch H</searchLink>; Strengthening Oncology Services Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; South Africa Medical Research Council Common Epithelial Cancers Research Center, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; Department of Surgery, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.<br /><searchLink fieldCode="AU" term="%22Joffe+M%22">Joffe M</searchLink>; Strengthening Oncology Services Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; South Africa Medical Research Council Common Epithelial Cancers Research Center, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; SAMRC/Wits Developmental Pathways to Health Research Unit, Department of Pediatrics, Faculty of Health Sciences, University of the Witwatersrand Johannesburg, Johannesburg, South Africa.<br /><searchLink fieldCode="AU" term="%22Masimirembwa+C%22">Masimirembwa C</searchLink>; Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; Department of Surgery, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
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