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Biological brain age prediction using machine learning on structural neuroimaging data: Multi-cohort validation against biomarkers of Alzheimer's disease and neurodegeneration stratified by sex.

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Title: Biological brain age prediction using machine learning on structural neuroimaging data: Multi-cohort validation against biomarkers of Alzheimer's disease and neurodegeneration stratified by sex.
Authors: Cumplido-Mayoral I; Barcelonaβeta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain.; Universitat Pompeu Fabra, Barcelona, Spain., García-Prat M; Barcelonaβeta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain., Operto G; Barcelonaβeta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain.; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.; CIBER Fragilidad y Envejecimiento Saludable (CIBERFES), Madrid, France., Falcon C; Barcelonaβeta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain.; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, Spain., Shekari M; Barcelonaβeta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain.; Universitat Pompeu Fabra, Barcelona, Spain.; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain., Cacciaglia R; Barcelonaβeta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain.; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.; CIBER Fragilidad y Envejecimiento Saludable (CIBERFES), Madrid, France., Milà-Alomà M; Barcelonaβeta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain.; Universitat Pompeu Fabra, Barcelona, Spain.; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.; CIBER Fragilidad y Envejecimiento Saludable (CIBERFES), Madrid, France., Lorenzini L; Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, Netherlands., Ingala S; Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, Netherlands., Meije Wink A; Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, Netherlands., Mutsaerts HJMM; Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, Netherlands., Minguillón C; Barcelonaβeta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain.; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.; CIBER Fragilidad y Envejecimiento Saludable (CIBERFES), Madrid, France., Fauria K; Barcelonaβeta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain.; CIBER Fragilidad y Envejecimiento Saludable (CIBERFES), Madrid, France., Molinuevo JL; Barcelonaβeta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain., Haller S; CIRD Centre d'Imagerie Rive Droite, Geneva, Switzerland., Chetelat G; Normandie Univ, UNICAEN, INSERM, U1237, PhIND 'Physiopathology and Imaging of Neurological Disorders', Institut Blood and Brain, Cyceron, France., Waldman A; Centre for Dementia Prevention, Edinburgh Imaging, and UK Dementia Research Institute at The University of Edinburgh, Edinburgh, United Kingdom., Schwarz AJ; Takeda Pharmaceutical Company Ltd, Cambridge, United States., Barkhof F; Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.; Institutes of Neurology and Healthcare Engineering, University College London, London, United Kingdom., Suridjan I; Roche Diagnostics International Ltd, Rotkreuz, Switzerland., Kollmorgen G; Roche Diagnostics GmbH, Penzberg, Germany., Bayfield A; Roche Diagnostics GmbH, Penzberg, Germany., Zetterberg H; Institute of Neuroscience and Physiology, University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, United Kingdom.; Hong Kong Center for Neurodegenerative Diseases, Hong Kong, China.; UK Dementia Research Institute at UCL, London, United Kingdom., Blennow K; Institute of Neuroscience and Physiology, University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden., Suárez-Calvet M; Barcelonaβeta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain.; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.; CIBER Fragilidad y Envejecimiento Saludable (CIBERFES), Madrid, France.; Servei de Neurologia, Hospital del Mar, Barcelona, Spain., Vilaplana V; Department of Signal Theory and Communications, Universitat Politècnica de Catalunya, Barcelona, Spain., Gispert JD; Barcelonaβeta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain.; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, Spain.
Corporate Authors: ALFA study, EPAD study, ADNI study, OASIS study
Source: ELife [Elife] 2023 Apr 17; Vol. 12. Date of Electronic Publication: 2023 Apr 17.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Cumplido-Mayoral+I%22">Cumplido-Mayoral I</searchLink>; Barcelonaβeta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain.; Universitat Pompeu Fabra, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22García-Prat+M%22">García-Prat M</searchLink>; Barcelonaβeta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Operto+G%22">Operto G</searchLink>; Barcelonaβeta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain.; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.; CIBER Fragilidad y Envejecimiento Saludable (CIBERFES), Madrid, France.<br /><searchLink fieldCode="AU" term="%22Falcon+C%22">Falcon C</searchLink>; Barcelonaβeta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain.; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Shekari+M%22">Shekari M</searchLink>; Barcelonaβeta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain.; Universitat Pompeu Fabra, Barcelona, Spain.; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Cacciaglia+R%22">Cacciaglia R</searchLink>; Barcelonaβeta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain.; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.; CIBER Fragilidad y Envejecimiento Saludable (CIBERFES), Madrid, France.<br /><searchLink fieldCode="AU" term="%22Milà-Alomà+M%22">Milà-Alomà M</searchLink>; Barcelonaβeta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain.; Universitat Pompeu Fabra, Barcelona, Spain.; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.; CIBER Fragilidad y Envejecimiento Saludable (CIBERFES), Madrid, France.<br /><searchLink fieldCode="AU" term="%22Lorenzini+L%22">Lorenzini L</searchLink>; Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Ingala+S%22">Ingala S</searchLink>; 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