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Entospletinib with decitabine in acute myeloid leukemia with mutant TP53 or complex karyotype: A phase 2 substudy of the Beat AML Master Trial.

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Title: Entospletinib with decitabine in acute myeloid leukemia with mutant TP53 or complex karyotype: A phase 2 substudy of the Beat AML Master Trial.
Authors: Duong VH; University of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, Maryland, USA., Ruppert AS; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, USA., Mims AS; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, USA., Borate U; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, USA., Stein EM; Memorial Sloan Kettering Cancer Center, New York, New York, USA., Baer MR; University of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, Maryland, USA., Stock W; Section of Hematology/Oncology, University of Chicago, Chicago, Illinois, USA., Kovacsovics T; Huntsman Cancer Institute, The University of Utah, Salt Lake City, Utah, USA., Blum W; Winship Cancer Institute, Emory University, Atlanta, Georgia, USA., Arellano ML; Winship Cancer Institute, Emory University, Atlanta, Georgia, USA., Schiller GJ; David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California, USA., Olin RL; Helen Diller Family Comprehensive Cancer Center, University of California-San Francisco, San Francisco, California, USA., Foran JM; Hematology and Oncology, Mayo Clinic, Jacksonville, Florida, USA., Litzow MR; Departments of Medical Oncology, Hematology, and Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA., Lin TL; Division of Hematologic Malignancies and Cellular Therapeutics, University of Kansas Medical Center, Kansas City, Kansas, USA., Patel PA; University of Texas Southwestern Medical Center Medical School, Dallas, Texas, USA., Foster MC; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA., Redner RL; Hillman Cancer Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA., Al-Mansour Z; Department of Medicine, University of Florida, Gainesville, Florida, USA., Cogle CR; Department of Medicine, University of Florida, Gainesville, Florida, USA., Swords RT; Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, USA., Collins RH; University of Texas Southwestern Medical Center Medical School, Dallas, Texas, USA., Vergilio JA; Foundation Medicine, Cambridge, Massachusetts, USA., Heerema NA; Department of Pathology, College of Medicine, The Ohio State University, Columbus, Ohio, USA., Rosenberg L; The Leukemia & Lymphoma Society, Rye Brook, New York, USA., Yocum AO; The Leukemia & Lymphoma Society, Rye Brook, New York, USA., Marcus S; The Leukemia & Lymphoma Society, Rye Brook, New York, USA., Chen T; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, USA., Druggan F; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, USA., Stefanos M; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, USA., Gana TJ; Biopharmatech Consulting, Inc., Leesburg, Virginia, USA., Shoben AB; Division of Biostatistics, College of Public Health, The Ohio State University, Columbus, Ohio, USA., Druker BJ; Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, USA., Burd A; The Leukemia & Lymphoma Society, Rye Brook, New York, USA., Byrd JC; Internal Medicine, University of Cincinnati, Cincinnati, Ohio, USA., Levine RL; Memorial Sloan Kettering Cancer Center, New York, New York, USA., Boyiadzis MM; Hillman Cancer Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Source: Cancer [Cancer] 2023 Aug 01; Vol. 129 (15), pp. 2308-2320. Date of Electronic Publication: 2023 Apr 20.
Publication Type: Multicenter Study; Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Wiley Country of Publication: United States NLM ID: 0374236 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0142 (Electronic) Linking ISSN: 0008543X NLM ISO Abbreviation: Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Entospletinib with decitabine in acute myeloid leukemia with mutant TP53 or complex karyotype: A phase 2 substudy of the Beat AML Master Trial.
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  Data: <searchLink fieldCode="AU" term="%22Duong+VH%22">Duong VH</searchLink>; University of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Ruppert+AS%22">Ruppert AS</searchLink>; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Mims+AS%22">Mims AS</searchLink>; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Borate+U%22">Borate U</searchLink>; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Stein+EM%22">Stein EM</searchLink>; Memorial Sloan Kettering Cancer Center, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Baer+MR%22">Baer MR</searchLink>; University of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Stock+W%22">Stock W</searchLink>; Section of Hematology/Oncology, University of Chicago, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Kovacsovics+T%22">Kovacsovics T</searchLink>; Huntsman Cancer Institute, The University of Utah, Salt Lake City, Utah, USA.<br /><searchLink fieldCode="AU" term="%22Blum+W%22">Blum W</searchLink>; Winship Cancer Institute, Emory University, Atlanta, Georgia, USA.<br /><searchLink fieldCode="AU" term="%22Arellano+ML%22">Arellano ML</searchLink>; Winship Cancer Institute, Emory University, Atlanta, Georgia, USA.<br /><searchLink fieldCode="AU" term="%22Schiller+GJ%22">Schiller GJ</searchLink>; David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California, USA.<br /><searchLink fieldCode="AU" term="%22Olin+RL%22">Olin RL</searchLink>; Helen Diller Family Comprehensive Cancer Center, University of California-San Francisco, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Foran+JM%22">Foran JM</searchLink>; Hematology and Oncology, Mayo Clinic, Jacksonville, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Litzow+MR%22">Litzow MR</searchLink>; Departments of Medical Oncology, Hematology, and Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Lin+TL%22">Lin TL</searchLink>; Division of Hematologic Malignancies and Cellular Therapeutics, University of Kansas Medical Center, Kansas City, Kansas, USA.<br /><searchLink fieldCode="AU" term="%22Patel+PA%22">Patel PA</searchLink>; University of Texas Southwestern Medical Center Medical School, Dallas, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Foster+MC%22">Foster MC</searchLink>; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Redner+RL%22">Redner RL</searchLink>; Hillman Cancer Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Al-Mansour+Z%22">Al-Mansour Z</searchLink>; Department of Medicine, University of Florida, Gainesville, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Cogle+CR%22">Cogle CR</searchLink>; Department of Medicine, University of Florida, Gainesville, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Swords+RT%22">Swords RT</searchLink>; Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, USA.<br /><searchLink fieldCode="AU" term="%22Collins+RH%22">Collins RH</searchLink>; University of Texas Southwestern Medical Center Medical School, Dallas, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Vergilio+JA%22">Vergilio JA</searchLink>; Foundation Medicine, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Heerema+NA%22">Heerema NA</searchLink>; Department of Pathology, College of Medicine, The Ohio State University, Columbus, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Rosenberg+L%22">Rosenberg L</searchLink>; The Leukemia & Lymphoma Society, Rye Brook, New York, USA.<br /><searchLink fieldCode="AU" term="%22Yocum+AO%22">Yocum AO</searchLink>; The Leukemia & Lymphoma Society, Rye Brook, New York, USA.<br /><searchLink fieldCode="AU" term="%22Marcus+S%22">Marcus S</searchLink>; The Leukemia & Lymphoma Society, Rye Brook, New York, USA.<br /><searchLink fieldCode="AU" term="%22Chen+T%22">Chen T</searchLink>; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Druggan+F%22">Druggan F</searchLink>; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Stefanos+M%22">Stefanos M</searchLink>; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Gana+TJ%22">Gana TJ</searchLink>; Biopharmatech Consulting, Inc., Leesburg, Virginia, USA.<br /><searchLink fieldCode="AU" term="%22Shoben+AB%22">Shoben AB</searchLink>; Division of Biostatistics, College of Public Health, The Ohio State University, Columbus, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Druker+BJ%22">Druker BJ</searchLink>; Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, USA.<br /><searchLink fieldCode="AU" term="%22Burd+A%22">Burd A</searchLink>; The Leukemia & Lymphoma Society, Rye Brook, New York, USA.<br /><searchLink fieldCode="AU" term="%22Byrd+JC%22">Byrd JC</searchLink>; Internal Medicine, University of Cincinnati, Cincinnati, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Levine+RL%22">Levine RL</searchLink>; Memorial Sloan Kettering Cancer Center, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Boyiadzis+MM%22">Boyiadzis MM</searchLink>; Hillman Cancer Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
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  Data: <searchLink fieldCode="JN" term="%220374236%22">Cancer</searchLink> [Cancer] 2023 Aug 01; Vol. 129 (15), pp. 2308-2320. <i>Date of Electronic Publication: </i>2023 Apr 20.
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