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Development and validation of DNA methylation scores in two European cohorts augment 10-year risk prediction of type 2 diabetes.

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Title: Development and validation of DNA methylation scores in two European cohorts augment 10-year risk prediction of type 2 diabetes.
Authors: Cheng Y; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland., Gadd DA; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Gieger C; Research Unit Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research, München-Neuherberg, Germany., Monterrubio-Gómez K; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Zhang Y; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Berta I; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Stam MJ; School of Informatics, University of Edinburgh, Edinburgh, UK., Szlachetka N; School of Informatics, University of Edinburgh, Edinburgh, UK., Lobzaev E; School of Informatics, University of Edinburgh, Edinburgh, UK., Wrobel N; Edinburgh Clinical Research Facility, University of Edinburgh, Western General Hospital, Edinburgh, UK., Murphy L; Edinburgh Clinical Research Facility, University of Edinburgh, Western General Hospital, Edinburgh, UK., Campbell A; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Nangle C; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Walker RM; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh BioQuarter, Edinburgh, UK., Fawns-Ritchie C; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.; Department of Psychology, University of Edinburgh, Edinburgh, UK., Peters A; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research, München-Neuherberg, Germany.; German Centre for Cardiovascular Research, Partner Site Munich Heart Alliance, München, Germany., Rathmann W; German Center for Diabetes Research, München-Neuherberg, Germany.; Institute for Biometrics and Epidemiology, German Diabetes Center, Leibniz Institute for Diabetes Research at Heinrich Heine University, Düsseldorf, Germany., Porteous DJ; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Evans KL; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., McIntosh AM; Division of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK., Cannings TI; School of Mathematics, University of Edinburgh, Edinburgh, UK., Waldenberger M; Research Unit Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Ganna A; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland., McCartney DL; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Vallejos CA; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK. catalina.vallejos@ed.ac.uk.; The Alan Turing Institute, London, UK. catalina.vallejos@ed.ac.uk., Marioni RE; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK. riccardo.marioni@ed.ac.uk.
Source: Nature aging [Nat Aging] 2023 Apr; Vol. 3 (4), pp. 450-458. Date of Electronic Publication: 2023 Apr 06.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Group US Country of Publication: United States NLM ID: 101773306 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2662-8465 (Electronic) Linking ISSN: 26628465 NLM ISO Abbreviation: Nat Aging Subsets: MEDLINE
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Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Berta+I%22">Berta I</searchLink>; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Stam+MJ%22">Stam MJ</searchLink>; School of Informatics, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Szlachetka+N%22">Szlachetka N</searchLink>; School of Informatics, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Lobzaev+E%22">Lobzaev E</searchLink>; School of Informatics, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Wrobel+N%22">Wrobel N</searchLink>; Edinburgh Clinical Research Facility, University of Edinburgh, Western General Hospital, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Murphy+L%22">Murphy L</searchLink>; 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Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Vallejos+CA%22">Vallejos CA</searchLink>; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK. catalina.vallejos@ed.ac.uk.; The Alan Turing Institute, London, UK. catalina.vallejos@ed.ac.uk.<br /><searchLink fieldCode="AU" term="%22Marioni+RE%22">Marioni RE</searchLink>; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK. riccardo.marioni@ed.ac.uk.
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