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BRCA2 Germline Mutations Identify Gastric Cancers Responsive to PARP Inhibitors.

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Title: BRCA2 Germline Mutations Identify Gastric Cancers Responsive to PARP Inhibitors.
Authors: Petrelli A; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy., Rizzolio S; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy., Pietrantonio F; Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Bellomo SE; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy.; Department of Oncology, University of Torino, Candiolo, Italy., Benelli M; Bioinformatics Unit, Oncology Department, Nuovo Ospedale-Santo Stefano, Prato, Italy., De Cecco L; Molecular Mechanisms Unit, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Romagnoli D; Bioinformatics Unit, Oncology Department, Nuovo Ospedale-Santo Stefano, Prato, Italy., Berrino E; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy.; Department of Medical Sciences, University of Torino, Torino, Italy., Orrù C; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy., Ribisi S; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy.; Department of Oncology, University of Torino, Candiolo, Italy., Moya-Rull D; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy., Migliore C; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy.; Department of Oncology, University of Torino, Candiolo, Italy., Conticelli D; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy.; Department of Oncology, University of Torino, Candiolo, Italy., Maina IM; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy.; Department of Oncology, University of Torino, Candiolo, Italy., Puliga E; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy., Serra V; Experimental Therapeutics Group, Vall d'Hebron Institute of Oncology, Barcelona, Spain., Pellegrino B; Department of Medicine and Surgery, University of Parma, Parma, Italy.; Oncology and Breast Unit, University Hospital of Parma, Parma, Italy.; Gruppo Oncologico Italiano di Ricerca Clinica (GOIRC), Parma, Italy., Llop-Guevara A; Experimental Therapeutics Group, Vall d'Hebron Institute of Oncology, Barcelona, Spain., Musolino A; Department of Medicine and Surgery, University of Parma, Parma, Italy.; Oncology and Breast Unit, University Hospital of Parma, Parma, Italy.; Gruppo Oncologico Italiano di Ricerca Clinica (GOIRC), Parma, Italy., Siena S; Department of Oncology and Hemato-oncology, University of Milan, Milan, Italy.; Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy., Sartore-Bianchi A; Department of Oncology and Hemato-oncology, University of Milan, Milan, Italy.; Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy., Prisciandaro M; Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.; Department of Oncology and Hemato-oncology, University of Milan, Milan, Italy., Morano F; Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Antista M; Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Fumagalli U; Digestive Surgery, European Institute of Oncology, IRCCS, Milan, Italy., De Manzoni G; Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, Section of Surgery, University of Verona, Verona, Italy., Degiuli M; Department of Oncology, University of Torino, Orbassano, Italy., Baiocchi GL; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy., Amisano MF; Department of Surgery, Santo Spirito Hospital, ASL-AL, Rome, Italy., Ferrero A; General and Oncological Surgery, Mauriziano Hospital, Torino, Italy., Marchiò C; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy.; Department of Medical Sciences, University of Torino, Torino, Italy., Corso S; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy.; Department of Oncology, University of Torino, Candiolo, Italy., Giordano S; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy.; Department of Oncology, University of Torino, Candiolo, Italy.
Source: Cancer research [Cancer Res] 2023 May 15; Vol. 83 (10), pp. 1699-1710.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: BRCA2 Germline Mutations Identify Gastric Cancers Responsive to PARP Inhibitors.
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  Data: <searchLink fieldCode="AU" term="%22Petrelli+A%22">Petrelli A</searchLink>; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy.<br /><searchLink fieldCode="AU" term="%22Rizzolio+S%22">Rizzolio S</searchLink>; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy.<br /><searchLink fieldCode="AU" term="%22Pietrantonio+F%22">Pietrantonio F</searchLink>; Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Bellomo+SE%22">Bellomo SE</searchLink>; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy.; Department of Oncology, University of Torino, Candiolo, Italy.<br /><searchLink fieldCode="AU" term="%22Benelli+M%22">Benelli M</searchLink>; Bioinformatics Unit, Oncology Department, Nuovo Ospedale-Santo Stefano, Prato, Italy.<br /><searchLink fieldCode="AU" term="%22De+Cecco+L%22">De Cecco L</searchLink>; Molecular Mechanisms Unit, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Romagnoli+D%22">Romagnoli D</searchLink>; Bioinformatics Unit, Oncology Department, Nuovo Ospedale-Santo Stefano, Prato, Italy.<br /><searchLink fieldCode="AU" term="%22Berrino+E%22">Berrino E</searchLink>; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy.; Department of Medical Sciences, University of Torino, Torino, Italy.<br /><searchLink fieldCode="AU" term="%22Orrù+C%22">Orrù C</searchLink>; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy.<br /><searchLink fieldCode="AU" term="%22Ribisi+S%22">Ribisi S</searchLink>; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy.; Department of Oncology, University of Torino, Candiolo, Italy.<br /><searchLink fieldCode="AU" term="%22Moya-Rull+D%22">Moya-Rull D</searchLink>; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy.<br /><searchLink fieldCode="AU" term="%22Migliore+C%22">Migliore C</searchLink>; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy.; Department of Oncology, University of Torino, Candiolo, Italy.<br /><searchLink fieldCode="AU" term="%22Conticelli+D%22">Conticelli D</searchLink>; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy.; Department of Oncology, University of Torino, Candiolo, Italy.<br /><searchLink fieldCode="AU" term="%22Maina+IM%22">Maina IM</searchLink>; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy.; Department of Oncology, University of Torino, Candiolo, Italy.<br /><searchLink fieldCode="AU" term="%22Puliga+E%22">Puliga E</searchLink>; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy.<br /><searchLink fieldCode="AU" term="%22Serra+V%22">Serra V</searchLink>; Experimental Therapeutics Group, Vall d'Hebron Institute of Oncology, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Pellegrino+B%22">Pellegrino B</searchLink>; Department of Medicine and Surgery, University of Parma, Parma, Italy.; Oncology and Breast Unit, University Hospital of Parma, Parma, Italy.; Gruppo Oncologico Italiano di Ricerca Clinica (GOIRC), Parma, Italy.<br /><searchLink fieldCode="AU" term="%22Llop-Guevara+A%22">Llop-Guevara A</searchLink>; Experimental Therapeutics Group, Vall d'Hebron Institute of Oncology, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Musolino+A%22">Musolino A</searchLink>; Department of Medicine and Surgery, University of Parma, Parma, Italy.; Oncology and Breast Unit, University Hospital of Parma, Parma, Italy.; Gruppo Oncologico Italiano di Ricerca Clinica (GOIRC), Parma, Italy.<br /><searchLink fieldCode="AU" term="%22Siena+S%22">Siena S</searchLink>; Department of Oncology and Hemato-oncology, University of Milan, Milan, Italy.; Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Sartore-Bianchi+A%22">Sartore-Bianchi A</searchLink>; Department of Oncology and Hemato-oncology, University of Milan, Milan, Italy.; Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Prisciandaro+M%22">Prisciandaro M</searchLink>; Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.; Department of Oncology and Hemato-oncology, University of Milan, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Morano+F%22">Morano F</searchLink>; Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Antista+M%22">Antista M</searchLink>; Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Fumagalli+U%22">Fumagalli U</searchLink>; Digestive Surgery, European Institute of Oncology, IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22De+Manzoni+G%22">De Manzoni G</searchLink>; Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, Section of Surgery, University of Verona, Verona, Italy.<br /><searchLink fieldCode="AU" term="%22Degiuli+M%22">Degiuli M</searchLink>; Department of Oncology, University of Torino, Orbassano, Italy.<br /><searchLink fieldCode="AU" term="%22Baiocchi+GL%22">Baiocchi GL</searchLink>; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Amisano+MF%22">Amisano MF</searchLink>; Department of Surgery, Santo Spirito Hospital, ASL-AL, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Ferrero+A%22">Ferrero A</searchLink>; General and Oncological Surgery, Mauriziano Hospital, Torino, Italy.<br /><searchLink fieldCode="AU" term="%22Marchiò+C%22">Marchiò C</searchLink>; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy.; Department of Medical Sciences, University of Torino, Torino, Italy.<br /><searchLink fieldCode="AU" term="%22Corso+S%22">Corso S</searchLink>; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy.; Department of Oncology, University of Torino, Candiolo, Italy.<br /><searchLink fieldCode="AU" term="%22Giordano+S%22">Giordano S</searchLink>; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy.; Department of Oncology, University of Torino, Candiolo, Italy.
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