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Inhibition of VEGF binding to neuropilin-2 enhances chemosensitivity and inhibits metastasis in triple-negative breast cancer.

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Title: Inhibition of VEGF binding to neuropilin-2 enhances chemosensitivity and inhibits metastasis in triple-negative breast cancer.
Authors: Xu Z; aTyr Pharma, San Diego, CA 92121, USA., Goel HL; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA., Burkart C; aTyr Pharma, San Diego, CA 92121, USA., Burman L; aTyr Pharma, San Diego, CA 92121, USA., Chong YE; aTyr Pharma, San Diego, CA 92121, USA., Barber AG; aTyr Pharma, San Diego, CA 92121, USA., Geng Y; IAS HKUST - Scripps R&D Laboratory, Institute for Advanced Study, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.; Pangu Biopharma, 26th Floor, Three Exchange Square, 8 Connaught Place, Central, Hong Kong, China., Zhai L; IAS HKUST - Scripps R&D Laboratory, Institute for Advanced Study, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.; Pangu Biopharma, 26th Floor, Three Exchange Square, 8 Connaught Place, Central, Hong Kong, China., Wang M; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA., Kumar A; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA., Menefee A; aTyr Pharma, San Diego, CA 92121, USA., Polizzi C; aTyr Pharma, San Diego, CA 92121, USA., Eide L; aTyr Pharma, San Diego, CA 92121, USA., Rauch K; aTyr Pharma, San Diego, CA 92121, USA., Rahman J; aTyr Pharma, San Diego, CA 92121, USA., Hamel K; aTyr Pharma, San Diego, CA 92121, USA., Fogassy Z; aTyr Pharma, San Diego, CA 92121, USA., Klopp-Savino S; aTyr Pharma, San Diego, CA 92121, USA., Paz S; aTyr Pharma, San Diego, CA 92121, USA., Zhang M; IAS HKUST - Scripps R&D Laboratory, Institute for Advanced Study, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China., Cubitt A; aTyr Pharma, San Diego, CA 92121, USA., Nangle LA; aTyr Pharma, San Diego, CA 92121, USA., Mercurio AM; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Source: Science translational medicine [Sci Transl Med] 2023 May 03; Vol. 15 (694), pp. eadf1128. Date of Electronic Publication: 2023 May 03.
Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Inhibition of VEGF binding to neuropilin-2 enhances chemosensitivity and inhibits metastasis in triple-negative breast cancer.
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  Data: <searchLink fieldCode="AU" term="%22Xu+Z%22">Xu Z</searchLink>; aTyr Pharma, San Diego, CA 92121, USA.<br /><searchLink fieldCode="AU" term="%22Goel+HL%22">Goel HL</searchLink>; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.<br /><searchLink fieldCode="AU" term="%22Burkart+C%22">Burkart C</searchLink>; aTyr Pharma, San Diego, CA 92121, USA.<br /><searchLink fieldCode="AU" term="%22Burman+L%22">Burman L</searchLink>; aTyr Pharma, San Diego, CA 92121, USA.<br /><searchLink fieldCode="AU" term="%22Chong+YE%22">Chong YE</searchLink>; aTyr Pharma, San Diego, CA 92121, USA.<br /><searchLink fieldCode="AU" term="%22Barber+AG%22">Barber AG</searchLink>; aTyr Pharma, San Diego, CA 92121, USA.<br /><searchLink fieldCode="AU" term="%22Geng+Y%22">Geng Y</searchLink>; IAS HKUST - Scripps R&D Laboratory, Institute for Advanced Study, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.; Pangu Biopharma, 26th Floor, Three Exchange Square, 8 Connaught Place, Central, Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Zhai+L%22">Zhai L</searchLink>; IAS HKUST - Scripps R&D Laboratory, Institute for Advanced Study, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.; Pangu Biopharma, 26th Floor, Three Exchange Square, 8 Connaught Place, Central, Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Wang+M%22">Wang M</searchLink>; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.<br /><searchLink fieldCode="AU" term="%22Kumar+A%22">Kumar A</searchLink>; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.<br /><searchLink fieldCode="AU" term="%22Menefee+A%22">Menefee A</searchLink>; aTyr Pharma, San Diego, CA 92121, USA.<br /><searchLink fieldCode="AU" term="%22Polizzi+C%22">Polizzi C</searchLink>; aTyr Pharma, San Diego, CA 92121, USA.<br /><searchLink fieldCode="AU" term="%22Eide+L%22">Eide L</searchLink>; aTyr Pharma, San Diego, CA 92121, USA.<br /><searchLink fieldCode="AU" term="%22Rauch+K%22">Rauch K</searchLink>; aTyr Pharma, San Diego, CA 92121, USA.<br /><searchLink fieldCode="AU" term="%22Rahman+J%22">Rahman J</searchLink>; aTyr Pharma, San Diego, CA 92121, USA.<br /><searchLink fieldCode="AU" term="%22Hamel+K%22">Hamel K</searchLink>; aTyr Pharma, San Diego, CA 92121, USA.<br /><searchLink fieldCode="AU" term="%22Fogassy+Z%22">Fogassy Z</searchLink>; aTyr Pharma, San Diego, CA 92121, USA.<br /><searchLink fieldCode="AU" term="%22Klopp-Savino+S%22">Klopp-Savino S</searchLink>; aTyr Pharma, San Diego, CA 92121, USA.<br /><searchLink fieldCode="AU" term="%22Paz+S%22">Paz S</searchLink>; aTyr Pharma, San Diego, CA 92121, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+M%22">Zhang M</searchLink>; IAS HKUST - Scripps R&D Laboratory, Institute for Advanced Study, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Cubitt+A%22">Cubitt A</searchLink>; aTyr Pharma, San Diego, CA 92121, USA.<br /><searchLink fieldCode="AU" term="%22Nangle+LA%22">Nangle LA</searchLink>; aTyr Pharma, San Diego, CA 92121, USA.<br /><searchLink fieldCode="AU" term="%22Mercurio+AM%22">Mercurio AM</searchLink>; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
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  Data: <searchLink fieldCode="JN" term="%22101505086%22">Science translational medicine</searchLink> [Sci Transl Med] 2023 May 03; Vol. 15 (694), pp. eadf1128. <i>Date of Electronic Publication: </i>2023 May 03.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+the+Advancement+of+Science%22">American Association for the Advancement of Science </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101505086 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1946-6242 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2219466234%22">19466234 </searchLink><i>NLM ISO Abbreviation: </i>Sci Transl Med <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=37134152
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        Value: 10.1126/scitranslmed.adf1128
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