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Discovery of arylsulfonamides as a novel class of allosteric integrase inhibitors with antiviral activity.

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Title: Discovery of arylsulfonamides as a novel class of allosteric integrase inhibitors with antiviral activity.
Authors: Wang C; Discovery Chemistry, Merck & Co., Inc., West Point, PA 19486, USA., Adam GC; Screening and Protein Science, Merck & Co., Inc., West Point, PA 19486, USA., Burlein C; Pharmacology, Merck & Co., Inc., West Point, PA 19486, USA., Carroll S; Pharmacology, Merck & Co., Inc., West Point, PA 19486, USA., Dankulich W; Discovery Chemistry, Merck & Co., Inc., West Point, PA 19486, USA., Diamond T; Infectious Disease Biology Discovery, Merck & Co., Inc., West Point, PA 19486, USA., Grobler J; Infectious Disease Biology Discovery, Merck & Co., Inc., West Point, PA 19486, USA., Heath J; Infectious Disease Biology Discovery, Merck & Co., Inc., West Point, PA 19486, USA., Johnson A; Discovery Chemistry, Merck & Co., Inc., West Point, PA 19486, USA., Klein D; Computational and Structural Chemistry, Merck & Co., Inc., West Point, PA 19486, USA., Krosky D; Pharmacology, Merck & Co., Inc., West Point, PA 19486, USA., Narayan K; Pharmacology, Merck & Co., Inc., West Point, PA 19486, USA., Ou Y; Pharmacology, Merck & Co., Inc., West Point, PA 19486, USA., Sanders J; Computational and Structural Chemistry, Merck & Co., Inc., West Point, PA 19486, USA., Sharma S; Screening and Protein Science, Merck & Co., Inc., West Point, PA 19486, USA., Xu M; Pharmacology, Merck & Co., Inc., West Point, PA 19486, USA., Converso A; Discovery Chemistry, Merck & Co., Inc., West Point, PA 19486, USA. Electronic address: antonella_converso@merck.com.
Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2023 Jun 01; Vol. 89, pp. 129303. Date of Electronic Publication: 2023 May 03.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Discovery of arylsulfonamides as a novel class of allosteric integrase inhibitors with antiviral activity.
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        Value: 10.1016/j.bmcl.2023.129303
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              Text: 2023 Jun 01
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              Y: 2023
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