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Vaginal epithelial dysfunction is mediated by the microbiome, metabolome, and mTOR signaling.

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Title: Vaginal epithelial dysfunction is mediated by the microbiome, metabolome, and mTOR signaling.
Authors: Berard AR; Department of Obstetrics & Gynecology, University of Manitoba, Winnipeg, MB R3E 3P5, Canada; Center for Global Health and Diseases, Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA., Brubaker DK; Weldon School of Biomedical Engineering and Regenstrief Center for Healthcare Engineering, Purdue University, West Lafayette, IN 47907, USA., Birse K; Department of Obstetrics & Gynecology, University of Manitoba, Winnipeg, MB R3E 3P5, Canada; Center for Global Health and Diseases, Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA., Lamont A; Department of Obstetrics & Gynecology, University of Manitoba, Winnipeg, MB R3E 3P5, Canada., Mackelprang RD; Department of Global Health, University of Washington, Seattle, WA 98105, USA., Noël-Romas L; Department of Obstetrics & Gynecology, University of Manitoba, Winnipeg, MB R3E 3P5, Canada; Center for Global Health and Diseases, Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA., Perner M; Medical Microbiology and Infectious Disease University of Manitoba, Winnipeg, MB R3E 0J9, Canada., Hou X; Department of Global Health, University of Washington, Seattle, WA 98105, USA., Irungu E; Partners in Health Research and Development, Kenya Medical Research Institute, Mbagathi Road, Nairobi, Kenya., Mugo N; Department of Global Health, University of Washington, Seattle, WA 98105, USA; Partners in Health Research and Development, Kenya Medical Research Institute, Mbagathi Road, Nairobi, Kenya., Knodel S; Department of Obstetrics & Gynecology, University of Manitoba, Winnipeg, MB R3E 3P5, Canada; Center for Global Health and Diseases, Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA., Muwonge TR; Infectious Disease Institute, Makerere University, Makerere, Kampala, Uganda., Katabira E; Infectious Disease Institute, Makerere University, Makerere, Kampala, Uganda., Hughes SM; Department of Obstetrics and Gynecology, University of Washington, Seattle, WA 98195, USA., Levy C; Department of Obstetrics and Gynecology, University of Washington, Seattle, WA 98195, USA., Calienes FL; Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA., Lauffenburger DA; Department of Biological Engineering, MIT, Cambridge, MA 02142, USA., Baeten JM; Department of Global Health, University of Washington, Seattle, WA 98105, USA; Department of Medicine, University of Washington, Seattle, WA 98195, USA; Department of Epidemiology, University of Washington, Seattle, WA 98195, USA; Gilead Sciences, Foster City, CA 94404, USA., Celum C; Department of Global Health, University of Washington, Seattle, WA 98105, USA; Department of Medicine, University of Washington, Seattle, WA 98195, USA; Department of Epidemiology, University of Washington, Seattle, WA 98195, USA., Hladik F; Department of Obstetrics and Gynecology, University of Washington, Seattle, WA 98195, USA; Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Department of Medicine, University of Washington, Seattle, WA 98195, USA., Lingappa J; Department of Global Health, University of Washington, Seattle, WA 98105, USA; Department of Medicine, University of Washington, Seattle, WA 98195, USA; Department of Pediatrics, University of Washington, Seattle, WA 98195, USA., Burgener AD; Department of Obstetrics & Gynecology, University of Manitoba, Winnipeg, MB R3E 3P5, Canada; Center for Global Health and Diseases, Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA; Department of Medicine Solna, Karolinska Institutet, Framstegsgatan, 171 64 Solna, Sweden. Electronic address: adam.burgener@case.edu.
Source: Cell reports [Cell Rep] 2023 May 30; Vol. 42 (5), pp. 112474. Date of Electronic Publication: 2023 May 06.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Vaginal epithelial dysfunction is mediated by the microbiome, metabolome, and mTOR signaling.
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  Data: <searchLink fieldCode="AU" term="%22Berard+AR%22">Berard AR</searchLink>; Department of Obstetrics & Gynecology, University of Manitoba, Winnipeg, MB R3E 3P5, Canada; Center for Global Health and Diseases, Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA.<br /><searchLink fieldCode="AU" term="%22Brubaker+DK%22">Brubaker DK</searchLink>; Weldon School of Biomedical Engineering and Regenstrief Center for Healthcare Engineering, Purdue University, West Lafayette, IN 47907, USA.<br /><searchLink fieldCode="AU" term="%22Birse+K%22">Birse K</searchLink>; Department of Obstetrics & Gynecology, University of Manitoba, Winnipeg, MB R3E 3P5, Canada; Center for Global Health and Diseases, Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA.<br /><searchLink fieldCode="AU" term="%22Lamont+A%22">Lamont A</searchLink>; Department of Obstetrics & Gynecology, University of Manitoba, Winnipeg, MB R3E 3P5, Canada.<br /><searchLink fieldCode="AU" term="%22Mackelprang+RD%22">Mackelprang RD</searchLink>; Department of Global Health, University of Washington, Seattle, WA 98105, USA.<br /><searchLink fieldCode="AU" term="%22Noël-Romas+L%22">Noël-Romas L</searchLink>; Department of Obstetrics & Gynecology, University of Manitoba, Winnipeg, MB R3E 3P5, Canada; Center for Global Health and Diseases, Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA.<br /><searchLink fieldCode="AU" term="%22Perner+M%22">Perner M</searchLink>; Medical Microbiology and Infectious Disease University of Manitoba, Winnipeg, MB R3E 0J9, Canada.<br /><searchLink fieldCode="AU" term="%22Hou+X%22">Hou X</searchLink>; Department of Global Health, University of Washington, Seattle, WA 98105, USA.<br /><searchLink fieldCode="AU" term="%22Irungu+E%22">Irungu E</searchLink>; Partners in Health Research and Development, Kenya Medical Research Institute, Mbagathi Road, Nairobi, Kenya.<br /><searchLink fieldCode="AU" term="%22Mugo+N%22">Mugo N</searchLink>; Department of Global Health, University of Washington, Seattle, WA 98105, USA; Partners in Health Research and Development, Kenya Medical Research Institute, Mbagathi Road, Nairobi, Kenya.<br /><searchLink fieldCode="AU" term="%22Knodel+S%22">Knodel S</searchLink>; Department of Obstetrics & Gynecology, University of Manitoba, Winnipeg, MB R3E 3P5, Canada; Center for Global Health and Diseases, Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA.<br /><searchLink fieldCode="AU" term="%22Muwonge+TR%22">Muwonge TR</searchLink>; Infectious Disease Institute, Makerere University, Makerere, Kampala, Uganda.<br /><searchLink fieldCode="AU" term="%22Katabira+E%22">Katabira E</searchLink>; Infectious Disease Institute, Makerere University, Makerere, Kampala, Uganda.<br /><searchLink fieldCode="AU" term="%22Hughes+SM%22">Hughes SM</searchLink>; Department of Obstetrics and Gynecology, University of Washington, Seattle, WA 98195, USA.<br /><searchLink fieldCode="AU" term="%22Levy+C%22">Levy C</searchLink>; Department of Obstetrics and Gynecology, University of Washington, Seattle, WA 98195, USA.<br /><searchLink fieldCode="AU" term="%22Calienes+FL%22">Calienes FL</searchLink>; Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.<br /><searchLink fieldCode="AU" term="%22Lauffenburger+DA%22">Lauffenburger DA</searchLink>; Department of Biological Engineering, MIT, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Baeten+JM%22">Baeten JM</searchLink>; Department of Global Health, University of Washington, Seattle, WA 98105, USA; Department of Medicine, University of Washington, Seattle, WA 98195, USA; Department of Epidemiology, University of Washington, Seattle, WA 98195, USA; Gilead Sciences, Foster City, CA 94404, USA.<br /><searchLink fieldCode="AU" term="%22Celum+C%22">Celum C</searchLink>; Department of Global Health, University of Washington, Seattle, WA 98105, USA; Department of Medicine, University of Washington, Seattle, WA 98195, USA; Department of Epidemiology, University of Washington, Seattle, WA 98195, USA.<br /><searchLink fieldCode="AU" term="%22Hladik+F%22">Hladik F</searchLink>; Department of Obstetrics and Gynecology, University of Washington, Seattle, WA 98195, USA; Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Department of Medicine, University of Washington, Seattle, WA 98195, USA.<br /><searchLink fieldCode="AU" term="%22Lingappa+J%22">Lingappa J</searchLink>; Department of Global Health, University of Washington, Seattle, WA 98105, USA; Department of Medicine, University of Washington, Seattle, WA 98195, USA; Department of Pediatrics, University of Washington, Seattle, WA 98195, USA.<br /><searchLink fieldCode="AU" term="%22Burgener+AD%22">Burgener AD</searchLink>; Department of Obstetrics & Gynecology, University of Manitoba, Winnipeg, MB R3E 3P5, Canada; Center for Global Health and Diseases, Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA; Department of Medicine Solna, Karolinska Institutet, Framstegsgatan, 171 64 Solna, Sweden. Electronic address: adam.burgener@case.edu.
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  Data: <searchLink fieldCode="JN" term="%22101573691%22">Cell reports</searchLink> [Cell Rep] 2023 May 30; Vol. 42 (5), pp. 112474. <i>Date of Electronic Publication: </i>2023 May 06.
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