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Targeting stromal cell sialylation reverses T cell-mediated immunosuppression in the tumor microenvironment.

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Title: Targeting stromal cell sialylation reverses T cell-mediated immunosuppression in the tumor microenvironment.
Authors: Egan H; Discipline of Pharmacology and Therapeutics, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland; Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland; Lambe Institute for Translational Research, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland., Treacy O; Discipline of Pharmacology and Therapeutics, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland; Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland; Lambe Institute for Translational Research, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland., Lynch K; Discipline of Pharmacology and Therapeutics, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland; Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland; Lambe Institute for Translational Research, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland., Leonard NA; Discipline of Pharmacology and Therapeutics, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland; Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland; Lambe Institute for Translational Research, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland., O'Malley G; Discipline of Pharmacology and Therapeutics, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland; Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland; Lambe Institute for Translational Research, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland., Reidy E; Discipline of Pharmacology and Therapeutics, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland; Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland; Lambe Institute for Translational Research, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland; CÚRAM, SFI Research Centre for Medical Devices, University of Galway, Galway, Ireland., O'Neill A; Discipline of Pharmacology and Therapeutics, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland; Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland; Lambe Institute for Translational Research, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland., Corry SM; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK., De Veirman K; Laboratory for Haematology and Immunology (HEIM), Department of Biomedical Sciences, Vrije Universiteit Brussel, Brussels, Belgium., Vanderkerken K; Laboratory for Haematology and Immunology (HEIM), Department of Biomedical Sciences, Vrije Universiteit Brussel, Brussels, Belgium., Egan LJ; Discipline of Pharmacology and Therapeutics, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland; Lambe Institute for Translational Research, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland., Ritter T; Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland; CÚRAM, SFI Research Centre for Medical Devices, University of Galway, Galway, Ireland., Hogan AM; Lambe Institute for Translational Research, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland; Department of Colorectal Surgery, Galway University Hospital, Galway, Ireland., Redmond K; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK., Peng L; Palleon Pharmaceuticals, Waltham, MA 02451, USA., Che J; Palleon Pharmaceuticals, Waltham, MA 02451, USA., Gatlin W; Palleon Pharmaceuticals, Waltham, MA 02451, USA., Jayaraman P; Palleon Pharmaceuticals, Waltham, MA 02451, USA., Sheehan M; Division of Anatomical Pathology, Galway University Hospital, Galway, Ireland., Canney A; Division of Anatomical Pathology, Galway University Hospital, Galway, Ireland., Hynes SO; Division of Anatomical Pathology, Galway University Hospital, Galway, Ireland; Discipline of Pathology, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland., Kerr EM; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK., Dunne PD; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK; Cancer Research UK Beatson Institute, Glasgow, UK., O'Dwyer ME; Lambe Institute for Translational Research, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland; Blood Cancer Network of Ireland (BCNI), Galway, Ireland; Department of Hematology, Galway University Hospital, Galway, Ireland., Ryan AE; Discipline of Pharmacology and Therapeutics, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland; Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland; Lambe Institute for Translational Research, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland; CÚRAM, SFI Research Centre for Medical Devices, University of Galway, Galway, Ireland. Electronic address: aideen.ryan@universityofgalway.ie.
Source: Cell reports [Cell Rep] 2023 May 30; Vol. 42 (5), pp. 112475. Date of Electronic Publication: 2023 May 10.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
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  Data: Targeting stromal cell sialylation reverses T cell-mediated immunosuppression in the tumor microenvironment.
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  Data: <searchLink fieldCode="AU" term="%22Egan+H%22">Egan H</searchLink>; Discipline of Pharmacology and Therapeutics, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland; Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland; Lambe Institute for Translational Research, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland.<br /><searchLink fieldCode="AU" term="%22Treacy+O%22">Treacy O</searchLink>; Discipline of Pharmacology and Therapeutics, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland; Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland; Lambe Institute for Translational Research, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland.<br /><searchLink fieldCode="AU" term="%22Lynch+K%22">Lynch K</searchLink>; Discipline of Pharmacology and Therapeutics, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland; Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland; Lambe Institute for Translational Research, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland.<br /><searchLink fieldCode="AU" term="%22Leonard+NA%22">Leonard NA</searchLink>; Discipline of Pharmacology and Therapeutics, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland; Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland; Lambe Institute for Translational Research, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland.<br /><searchLink fieldCode="AU" term="%22O'Malley+G%22">O'Malley G</searchLink>; Discipline of Pharmacology and Therapeutics, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland; Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland; Lambe Institute for Translational Research, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland.<br /><searchLink fieldCode="AU" term="%22Reidy+E%22">Reidy E</searchLink>; Discipline of Pharmacology and Therapeutics, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland; Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland; Lambe Institute for Translational Research, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland; CÚRAM, SFI Research Centre for Medical Devices, University of Galway, Galway, Ireland.<br /><searchLink fieldCode="AU" term="%22O'Neill+A%22">O'Neill A</searchLink>; Discipline of Pharmacology and Therapeutics, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland; Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland; Lambe Institute for Translational Research, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland.<br /><searchLink fieldCode="AU" term="%22Corry+SM%22">Corry SM</searchLink>; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK.<br /><searchLink fieldCode="AU" term="%22De+Veirman+K%22">De Veirman K</searchLink>; Laboratory for Haematology and Immunology (HEIM), Department of Biomedical Sciences, Vrije Universiteit Brussel, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Vanderkerken+K%22">Vanderkerken K</searchLink>; Laboratory for Haematology and Immunology (HEIM), Department of Biomedical Sciences, Vrije Universiteit Brussel, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Egan+LJ%22">Egan LJ</searchLink>; Discipline of Pharmacology and Therapeutics, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland; Lambe Institute for Translational Research, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland.<br /><searchLink fieldCode="AU" term="%22Ritter+T%22">Ritter T</searchLink>; Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland; CÚRAM, SFI Research Centre for Medical Devices, University of Galway, Galway, Ireland.<br /><searchLink fieldCode="AU" term="%22Hogan+AM%22">Hogan AM</searchLink>; Lambe Institute for Translational Research, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland; Department of Colorectal Surgery, Galway University Hospital, Galway, Ireland.<br /><searchLink fieldCode="AU" term="%22Redmond+K%22">Redmond K</searchLink>; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK.<br /><searchLink fieldCode="AU" term="%22Peng+L%22">Peng L</searchLink>; Palleon Pharmaceuticals, Waltham, MA 02451, USA.<br /><searchLink fieldCode="AU" term="%22Che+J%22">Che J</searchLink>; Palleon Pharmaceuticals, Waltham, MA 02451, USA.<br /><searchLink fieldCode="AU" term="%22Gatlin+W%22">Gatlin W</searchLink>; Palleon Pharmaceuticals, Waltham, MA 02451, USA.<br /><searchLink fieldCode="AU" term="%22Jayaraman+P%22">Jayaraman P</searchLink>; Palleon Pharmaceuticals, Waltham, MA 02451, USA.<br /><searchLink fieldCode="AU" term="%22Sheehan+M%22">Sheehan M</searchLink>; Division of Anatomical Pathology, Galway University Hospital, Galway, Ireland.<br /><searchLink fieldCode="AU" term="%22Canney+A%22">Canney A</searchLink>; Division of Anatomical Pathology, Galway University Hospital, Galway, Ireland.<br /><searchLink fieldCode="AU" term="%22Hynes+SO%22">Hynes SO</searchLink>; Division of Anatomical Pathology, Galway University Hospital, Galway, Ireland; Discipline of Pathology, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland.<br /><searchLink fieldCode="AU" term="%22Kerr+EM%22">Kerr EM</searchLink>; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK.<br /><searchLink fieldCode="AU" term="%22Dunne+PD%22">Dunne PD</searchLink>; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK; Cancer Research UK Beatson Institute, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22O'Dwyer+ME%22">O'Dwyer ME</searchLink>; Lambe Institute for Translational Research, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland; Blood Cancer Network of Ireland (BCNI), Galway, Ireland; Department of Hematology, Galway University Hospital, Galway, Ireland.<br /><searchLink fieldCode="AU" term="%22Ryan+AE%22">Ryan AE</searchLink>; Discipline of Pharmacology and Therapeutics, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland; Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland; Lambe Institute for Translational Research, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland; CÚRAM, SFI Research Centre for Medical Devices, University of Galway, Galway, Ireland. Electronic address: aideen.ryan@universityofgalway.ie.
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