Large libraries of single-chain trimer peptide-MHCs enable antigen-specific CD8+ T cell discovery and analysis.
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| Title: | Large libraries of single-chain trimer peptide-MHCs enable antigen-specific CD8+ T cell discovery and analysis. |
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| Authors: | Chour W; Institute for Systems Biology, Seattle, WA, 98109, USA.; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA., Choi J; Institute for Systems Biology, Seattle, WA, 98109, USA., Xie J; Institute for Systems Biology, Seattle, WA, 98109, USA.; Molecular Engineering & Sciences Institute, University of Washington, Seattle, WA, 98195, USA., Chaffee ME; Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA., Schmitt TM; Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA., Finton K; Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA., DeLucia DC; Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA., Xu AM; Institute for Systems Biology, Seattle, WA, 98109, USA.; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, 91125, USA., Su Y; Institute for Systems Biology, Seattle, WA, 98109, USA.; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, 91125, USA., Chen DG; Institute for Systems Biology, Seattle, WA, 98109, USA.; Department of Microbiology and Department of Informatics, University of Washington, Seattle, WA, 98195, USA., Zhang R; Institute for Systems Biology, Seattle, WA, 98109, USA.; Department of Bioengineering, University of Washington, Seattle, WA, 98195, USA., Yuan D; Institute for Systems Biology, Seattle, WA, 98109, USA.; Department of Bioengineering, University of Washington, Seattle, WA, 98195, USA., Hong S; Institute for Systems Biology, Seattle, WA, 98109, USA., Ng AHC; Institute for Systems Biology, Seattle, WA, 98109, USA.; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, 91125, USA., Butler JZ; Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA., Edmark RA; Institute for Systems Biology, Seattle, WA, 98109, USA., Jones LC; Institute for Systems Biology, Seattle, WA, 98109, USA., Murray KM; Institute for Systems Biology, Seattle, WA, 98109, USA., Peng S; PACT Pharma, South San Francisco, CA, 94080, USA., Li G; Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, China.; Suzhou Institute of Systems Medicine, Suzhou, 215123, China.; Key Laboratory of Synthetic Biology Regulatory Element, Chinese Academy of Medical Sciences, Beijing, China., Strong RK; Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA., Lee JK; Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.; Division of Medical Oncology, Department of Medicine, University of Washington, Seattle, WA, 98195, USA., Goldman JD; Swedish Center for Research and Innovation, Swedish Medical Center, Seattle, WA, 98104, USA.; Division of Infectious Disease, Department of Medicine, University of Washington, Seattle, WA, 98195, USA., Greenberg PD; Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.; Division of Medical Oncology, Department of Medicine, University of Washington, Seattle, WA, 98195, USA.; Department of Immunology, University of Washington, Seattle, WA, 98195, USA., Heath JR; Institute for Systems Biology, Seattle, WA, 98109, USA. Jheath@isbscience.org.; Department of Bioengineering, University of Washington, Seattle, WA, 98195, USA. Jheath@isbscience.org. |
| Source: | Communications biology [Commun Biol] 2023 May 16; Vol. 6 (1), pp. 528. Date of Electronic Publication: 2023 May 16. |
| Publication Type: | Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural |
| Journal Info: | Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2399-3642 |
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| DOI: | 10.1038/s42003-023-04899-8 |
