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Delivery of PEGylated liposomal doxorubicin by bispecific antibodies improves treatment in models of high-risk childhood leukemia.

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Title: Delivery of PEGylated liposomal doxorubicin by bispecific antibodies improves treatment in models of high-risk childhood leukemia.
Authors: Moles E; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney 2052, Australia.; Australian Centre for Nanomedicine, Faculty of Engineering, UNSW Sydney, Sydney 2052, Australia.; School of Clinical Medicine, Medicine and Health, UNSW Sydney, Sydney 2052, Australia., Howard CB; Australian Institute for Bioengineering and Nanotechnology, University of Queensland, St Lucia 4072, Australia., Huda P; Australian Institute for Bioengineering and Nanotechnology, University of Queensland, St Lucia 4072, Australia., Karsa M; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney 2052, Australia.; School of Clinical Medicine, Medicine and Health, UNSW Sydney, Sydney 2052, Australia., McCalmont H; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney 2052, Australia.; School of Clinical Medicine, Medicine and Health, UNSW Sydney, Sydney 2052, Australia., Kimpton K; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney 2052, Australia.; School of Clinical Medicine, Medicine and Health, UNSW Sydney, Sydney 2052, Australia., Duly A; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney 2052, Australia.; School of Clinical Medicine, Medicine and Health, UNSW Sydney, Sydney 2052, Australia., Chen Y; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney 2052, Australia.; School of Clinical Medicine, Medicine and Health, UNSW Sydney, Sydney 2052, Australia., Huang Y; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney 2052, Australia.; School of Clinical Medicine, Medicine and Health, UNSW Sydney, Sydney 2052, Australia., Tursky ML; Department of Haematology and Bone Marrow Transplant, St Vincent's Hospital Sydney, Sydney 2010, Australia.; St Vincent's Centre for Applied Medical Research (AMR), Sydney 2010, Australia.; St Vincent Clinical School, Faculty of Medicine and Health, UNSW Sydney, Sydney 2052, Australia., Ma D; Department of Haematology and Bone Marrow Transplant, St Vincent's Hospital Sydney, Sydney 2010, Australia.; St Vincent's Centre for Applied Medical Research (AMR), Sydney 2010, Australia.; St Vincent Clinical School, Faculty of Medicine and Health, UNSW Sydney, Sydney 2052, Australia., Bustamante S; Bioanalytical Mass Spectrometry Facility, Mark Wainwright Analytical Centre, UNSW Sydney, Sydney 2052, Australia., Pickford R; Bioanalytical Mass Spectrometry Facility, Mark Wainwright Analytical Centre, UNSW Sydney, Sydney 2052, Australia., Connerty P; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney 2052, Australia.; School of Clinical Medicine, Medicine and Health, UNSW Sydney, Sydney 2052, Australia., Omari S; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney 2052, Australia.; School of Clinical Medicine, Medicine and Health, UNSW Sydney, Sydney 2052, Australia., Jolly CJ; School of Biomedical Sciences, Lowy Cancer Research Centre, UNSW Sydney, Sydney 2052, Australia., Joshi S; School of Biomedical Sciences, Lowy Cancer Research Centre, UNSW Sydney, Sydney 2052, Australia., Shen S; School of Biomedical Sciences, Lowy Cancer Research Centre, UNSW Sydney, Sydney 2052, Australia., Pimanda JE; School of Clinical Medicine, Medicine and Health, UNSW Sydney, Sydney 2052, Australia.; School of Biomedical Sciences, Lowy Cancer Research Centre, UNSW Sydney, Sydney 2052, Australia.; Department of Haematology, Prince of Wales Hospital, Sydney 2031, Australia., Dolnikov A; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney 2052, Australia.; School of Clinical Medicine, Medicine and Health, UNSW Sydney, Sydney 2052, Australia., Cheung LC; Leukaemia Translational Research Laboratory, Telethon Kids Cancer Centre, Telethon Kids Institute, Perth, Western Australia 6009, Australia.; Curtin Medical School, Curtin University, Perth, Western Australia 6102, Australia., Kotecha RS; Leukaemia Translational Research Laboratory, Telethon Kids Cancer Centre, Telethon Kids Institute, Perth, Western Australia 6009, Australia.; Curtin Medical School, Curtin University, Perth, Western Australia 6102, Australia.; Department of Clinical Haematology, Oncology, Blood and Marrow Transplantation, Perth Children's Hospital, Perth, Western Australia 6009, Australia.; School of Medicine, University of Western Australia, Perth, Western Australia 6009, Australia., Norris MD; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney 2052, Australia.; School of Clinical Medicine, Medicine and Health, UNSW Sydney, Sydney 2052, Australia.; University of New South Wales Centre for Childhood Cancer Research, UNSW Sydney, Sydney 2052, Australia., Haber M; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney 2052, Australia.; School of Clinical Medicine, Medicine and Health, UNSW Sydney, Sydney 2052, Australia., de Bock CE; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney 2052, Australia.; School of Clinical Medicine, Medicine and Health, UNSW Sydney, Sydney 2052, Australia., Somers K; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney 2052, Australia.; School of Clinical Medicine, Medicine and Health, UNSW Sydney, Sydney 2052, Australia., Lock RB; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney 2052, Australia.; School of Clinical Medicine, Medicine and Health, UNSW Sydney, Sydney 2052, Australia., Thurecht KJ; Australian Institute for Bioengineering and Nanotechnology, University of Queensland, St Lucia 4072, Australia.; Centre for Advanced Imaging, ARC Training Centre for Innovation in Biomedical Imaging Technologies, University of Queensland, St Lucia 4072, Australia., Kavallaris M; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney 2052, Australia.; Australian Centre for Nanomedicine, Faculty of Engineering, UNSW Sydney, Sydney 2052, Australia.; School of Clinical Medicine, Medicine and Health, UNSW Sydney, Sydney 2052, Australia.
Source: Science translational medicine [Sci Transl Med] 2023 May 17; Vol. 15 (696), pp. eabm1262. Date of Electronic Publication: 2023 May 17.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
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  Data: Delivery of PEGylated liposomal doxorubicin by bispecific antibodies improves treatment in models of high-risk childhood leukemia.
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  Data: <searchLink fieldCode="AU" term="%22Moles+E%22">Moles E</searchLink>; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney 2052, Australia.; Australian Centre for Nanomedicine, Faculty of Engineering, UNSW Sydney, Sydney 2052, Australia.; School of Clinical Medicine, Medicine and Health, UNSW Sydney, Sydney 2052, Australia.<br /><searchLink fieldCode="AU" term="%22Howard+CB%22">Howard CB</searchLink>; Australian Institute for Bioengineering and Nanotechnology, University of Queensland, St Lucia 4072, Australia.<br /><searchLink fieldCode="AU" term="%22Huda+P%22">Huda P</searchLink>; Australian Institute for Bioengineering and Nanotechnology, University of Queensland, St Lucia 4072, Australia.<br /><searchLink fieldCode="AU" term="%22Karsa+M%22">Karsa M</searchLink>; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney 2052, Australia.; School of Clinical Medicine, Medicine and Health, UNSW Sydney, Sydney 2052, Australia.<br /><searchLink fieldCode="AU" term="%22McCalmont+H%22">McCalmont H</searchLink>; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney 2052, Australia.; School of Clinical Medicine, Medicine and Health, UNSW Sydney, Sydney 2052, Australia.<br /><searchLink fieldCode="AU" term="%22Kimpton+K%22">Kimpton K</searchLink>; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney 2052, Australia.; School of Clinical Medicine, Medicine and Health, UNSW Sydney, Sydney 2052, Australia.<br /><searchLink fieldCode="AU" term="%22Duly+A%22">Duly A</searchLink>; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney 2052, Australia.; School of Clinical Medicine, Medicine and Health, UNSW Sydney, Sydney 2052, Australia.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney 2052, Australia.; School of Clinical Medicine, Medicine and Health, UNSW Sydney, Sydney 2052, Australia.<br /><searchLink fieldCode="AU" term="%22Huang+Y%22">Huang Y</searchLink>; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney 2052, Australia.; School of Clinical Medicine, Medicine and Health, UNSW Sydney, Sydney 2052, Australia.<br /><searchLink fieldCode="AU" term="%22Tursky+ML%22">Tursky ML</searchLink>; Department of Haematology and Bone Marrow Transplant, St Vincent's Hospital Sydney, Sydney 2010, Australia.; St Vincent's Centre for Applied Medical Research (AMR), Sydney 2010, Australia.; St Vincent Clinical School, Faculty of Medicine and Health, UNSW Sydney, Sydney 2052, Australia.<br /><searchLink fieldCode="AU" term="%22Ma+D%22">Ma D</searchLink>; Department of Haematology and Bone Marrow Transplant, St Vincent's Hospital Sydney, Sydney 2010, Australia.; St Vincent's Centre for Applied Medical Research (AMR), Sydney 2010, Australia.; St Vincent Clinical School, Faculty of Medicine and Health, UNSW Sydney, Sydney 2052, Australia.<br /><searchLink fieldCode="AU" term="%22Bustamante+S%22">Bustamante S</searchLink>; Bioanalytical Mass Spectrometry Facility, Mark Wainwright Analytical Centre, UNSW Sydney, Sydney 2052, Australia.<br /><searchLink fieldCode="AU" term="%22Pickford+R%22">Pickford R</searchLink>; Bioanalytical Mass Spectrometry Facility, Mark Wainwright Analytical Centre, UNSW Sydney, Sydney 2052, Australia.<br /><searchLink fieldCode="AU" term="%22Connerty+P%22">Connerty P</searchLink>; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney 2052, Australia.; School of Clinical Medicine, Medicine and Health, UNSW Sydney, Sydney 2052, Australia.<br /><searchLink fieldCode="AU" term="%22Omari+S%22">Omari S</searchLink>; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney 2052, Australia.; School of Clinical Medicine, Medicine and Health, UNSW Sydney, Sydney 2052, Australia.<br /><searchLink fieldCode="AU" term="%22Jolly+CJ%22">Jolly CJ</searchLink>; School of Biomedical Sciences, Lowy Cancer Research Centre, UNSW Sydney, Sydney 2052, Australia.<br /><searchLink fieldCode="AU" term="%22Joshi+S%22">Joshi S</searchLink>; School of Biomedical Sciences, Lowy Cancer Research Centre, UNSW Sydney, Sydney 2052, Australia.<br /><searchLink fieldCode="AU" term="%22Shen+S%22">Shen S</searchLink>; School of Biomedical Sciences, Lowy Cancer Research Centre, UNSW Sydney, Sydney 2052, Australia.<br /><searchLink fieldCode="AU" term="%22Pimanda+JE%22">Pimanda JE</searchLink>; School of Clinical Medicine, Medicine and Health, UNSW Sydney, Sydney 2052, Australia.; School of Biomedical Sciences, Lowy Cancer Research Centre, UNSW Sydney, Sydney 2052, Australia.; Department of Haematology, Prince of Wales Hospital, Sydney 2031, Australia.<br /><searchLink fieldCode="AU" term="%22Dolnikov+A%22">Dolnikov A</searchLink>; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney 2052, Australia.; School of Clinical Medicine, Medicine and Health, UNSW Sydney, Sydney 2052, Australia.<br /><searchLink fieldCode="AU" term="%22Cheung+LC%22">Cheung LC</searchLink>; Leukaemia Translational Research Laboratory, Telethon Kids Cancer Centre, Telethon Kids Institute, Perth, Western Australia 6009, Australia.; Curtin Medical School, Curtin University, Perth, Western Australia 6102, Australia.<br /><searchLink fieldCode="AU" term="%22Kotecha+RS%22">Kotecha RS</searchLink>; Leukaemia Translational Research Laboratory, Telethon Kids Cancer Centre, Telethon Kids Institute, Perth, Western Australia 6009, Australia.; Curtin Medical School, Curtin University, Perth, Western Australia 6102, Australia.; Department of Clinical Haematology, Oncology, Blood and Marrow Transplantation, Perth Children's Hospital, Perth, Western Australia 6009, Australia.; School of Medicine, University of Western Australia, Perth, Western Australia 6009, Australia.<br /><searchLink fieldCode="AU" term="%22Norris+MD%22">Norris MD</searchLink>; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney 2052, Australia.; School of Clinical Medicine, Medicine and Health, UNSW Sydney, Sydney 2052, Australia.; University of New South Wales Centre for Childhood Cancer Research, UNSW Sydney, Sydney 2052, Australia.<br /><searchLink fieldCode="AU" term="%22Haber+M%22">Haber M</searchLink>; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney 2052, Australia.; School of Clinical Medicine, Medicine and Health, UNSW Sydney, Sydney 2052, Australia.<br /><searchLink fieldCode="AU" term="%22de+Bock+CE%22">de Bock CE</searchLink>; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney 2052, Australia.; School of Clinical Medicine, Medicine and Health, UNSW Sydney, Sydney 2052, Australia.<br /><searchLink fieldCode="AU" term="%22Somers+K%22">Somers K</searchLink>; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney 2052, Australia.; School of Clinical Medicine, Medicine and Health, UNSW Sydney, Sydney 2052, Australia.<br /><searchLink fieldCode="AU" term="%22Lock+RB%22">Lock RB</searchLink>; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney 2052, Australia.; School of Clinical Medicine, Medicine and Health, UNSW Sydney, Sydney 2052, Australia.<br /><searchLink fieldCode="AU" term="%22Thurecht+KJ%22">Thurecht KJ</searchLink>; Australian Institute for Bioengineering and Nanotechnology, University of Queensland, St Lucia 4072, Australia.; Centre for Advanced Imaging, ARC Training Centre for Innovation in Biomedical Imaging Technologies, University of Queensland, St Lucia 4072, Australia.<br /><searchLink fieldCode="AU" term="%22Kavallaris+M%22">Kavallaris M</searchLink>; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney 2052, Australia.; Australian Centre for Nanomedicine, Faculty of Engineering, UNSW Sydney, Sydney 2052, Australia.; School of Clinical Medicine, Medicine and Health, UNSW Sydney, Sydney 2052, Australia.
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