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Preclinical characterization of the Toll-like receptor 7/8 antagonist MHV370 for lupus therapy.

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Title: Preclinical characterization of the Toll-like receptor 7/8 antagonist MHV370 for lupus therapy.
Authors: Hawtin S; Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4056 Basel, Switzerland., André C; Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4056 Basel, Switzerland., Collignon-Zipfel G; Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4056 Basel, Switzerland., Appenzeller S; Department of Orthopedics, Rheumatology, and Traumatology, School of Medical Science, University of Campinas (UNICAMP), Campinas, 13083-887 São Paulo, Brazil., Bannert B; Department of Rheumatology, University Hospital Basel and University of Basel, 4031 Basel, Switzerland., Baumgartner L; Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4056 Basel, Switzerland., Beck D; Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4056 Basel, Switzerland., Betschart C; Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4056 Basel, Switzerland., Boulay T; Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4056 Basel, Switzerland., Brunner HI; Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA., Ceci M; Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4056 Basel, Switzerland., Deane J; Novartis Institutes for BioMedical Research, Novartis Pharma AG, La Jolla, CA 92121, USA., Feifel R; Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4056 Basel, Switzerland., Ferrero E; Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4056 Basel, Switzerland., Kyburz D; Department of Rheumatology, University Hospital Basel and University of Basel, 4031 Basel, Switzerland., Lafossas F; Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4056 Basel, Switzerland., Loetscher P; Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4056 Basel, Switzerland., Merz-Stoeckle C; Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4056 Basel, Switzerland., Michellys P; Novartis Institutes for BioMedical Research, Novartis Pharma AG, La Jolla, CA 92121, USA., Nuesslein-Hildesheim B; Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4056 Basel, Switzerland., Raulf F; Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4056 Basel, Switzerland., Rush JS; Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4056 Basel, Switzerland., Ruzzante G; Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4056 Basel, Switzerland., Stein T; Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4056 Basel, Switzerland., Zaharevitz S; Novartis Institutes for BioMedical Research, Novartis Pharma AG, La Jolla, CA 92121, USA., Wieczorek G; Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4056 Basel, Switzerland., Siegel R; Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4056 Basel, Switzerland., Gergely P; Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4056 Basel, Switzerland., Shisha T; Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4056 Basel, Switzerland., Junt T; Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4056 Basel, Switzerland. Electronic address: tobias.junt@novartis.com.
Source: Cell reports. Medicine [Cell Rep Med] 2023 May 16; Vol. 4 (5), pp. 101036.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101766894 Publication Model: Print Cited Medium: Internet ISSN: 2666-3791 (Electronic) Linking ISSN: 26663791 NLM ISO Abbreviation: Cell Rep Med Subsets: MEDLINE
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  Data: Preclinical characterization of the Toll-like receptor 7/8 antagonist MHV370 for lupus therapy.
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  Data: <searchLink fieldCode="AU" term="%22Hawtin+S%22">Hawtin S</searchLink>; Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4056 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22André+C%22">André C</searchLink>; Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4056 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Collignon-Zipfel+G%22">Collignon-Zipfel G</searchLink>; Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4056 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Appenzeller+S%22">Appenzeller S</searchLink>; Department of Orthopedics, Rheumatology, and Traumatology, School of Medical Science, University of Campinas (UNICAMP), Campinas, 13083-887 São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Bannert+B%22">Bannert B</searchLink>; Department of Rheumatology, University Hospital Basel and University of Basel, 4031 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Baumgartner+L%22">Baumgartner L</searchLink>; Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4056 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Beck+D%22">Beck D</searchLink>; Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4056 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Betschart+C%22">Betschart C</searchLink>; Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4056 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Boulay+T%22">Boulay T</searchLink>; Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4056 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Brunner+HI%22">Brunner HI</searchLink>; Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.<br /><searchLink fieldCode="AU" term="%22Ceci+M%22">Ceci M</searchLink>; Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4056 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Deane+J%22">Deane J</searchLink>; Novartis Institutes for BioMedical Research, Novartis Pharma AG, La Jolla, CA 92121, USA.<br /><searchLink fieldCode="AU" term="%22Feifel+R%22">Feifel R</searchLink>; Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4056 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Ferrero+E%22">Ferrero E</searchLink>; Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4056 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Kyburz+D%22">Kyburz D</searchLink>; Department of Rheumatology, University Hospital Basel and University of Basel, 4031 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Lafossas+F%22">Lafossas F</searchLink>; Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4056 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Loetscher+P%22">Loetscher P</searchLink>; Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4056 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Merz-Stoeckle+C%22">Merz-Stoeckle C</searchLink>; Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4056 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Michellys+P%22">Michellys P</searchLink>; Novartis Institutes for BioMedical Research, Novartis Pharma AG, La Jolla, CA 92121, USA.<br /><searchLink fieldCode="AU" term="%22Nuesslein-Hildesheim+B%22">Nuesslein-Hildesheim B</searchLink>; Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4056 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Raulf+F%22">Raulf F</searchLink>; Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4056 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Rush+JS%22">Rush JS</searchLink>; Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4056 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Ruzzante+G%22">Ruzzante G</searchLink>; Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4056 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Stein+T%22">Stein T</searchLink>; Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4056 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Zaharevitz+S%22">Zaharevitz S</searchLink>; Novartis Institutes for BioMedical Research, Novartis Pharma AG, La Jolla, CA 92121, USA.<br /><searchLink fieldCode="AU" term="%22Wieczorek+G%22">Wieczorek G</searchLink>; Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4056 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Siegel+R%22">Siegel R</searchLink>; Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4056 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Gergely+P%22">Gergely P</searchLink>; Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4056 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Shisha+T%22">Shisha T</searchLink>; Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4056 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Junt+T%22">Junt T</searchLink>; Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4056 Basel, Switzerland. Electronic address: tobias.junt@novartis.com.
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